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3 - Countercurrrent Separation Processes

Published online by Cambridge University Press:  22 September 2018

David Pfister ,
Lucrèce Nicoud  and
Massimo Morbidelli
David Pfister
Affiliation:
Ypso Facto
Lucrèce Nicoud
Affiliation:
Massachusetts Institute of Technology
Massimo Morbidelli
Affiliation:
Eidgenössische Technische Hochschule Zürich
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Summary

This chapter provides basic concepts about multi-column counter-current chromatography. The benefit of counter-current contact in separation processes is demonstrated considering cascades of equilibrium stages. Based on this, the true moving bed (TMB) process and the simulated moving bed (SMB) process are introduced. Then, the design space of the TMB and SMB processes leading to a complete separation is identified, starting with simplistic systems and progressively introducing more complex effects, namely non-linear adsorption isotherms and mass transfer limitations. Finally, two process design approaches for multi-column chromatographic processes are presented: an empirical one, which allows to obtain a first guess of the operating conditions from a single-column experiment, and a model-based one, which allows a more rigorous determination of the process variables.

Keywords

counter-currentsimulated moving bedtrue moving beddesign spacetriangleprocess designmulti-column processesSMBchromatographysimulation
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Chapter
Information
Continuous Biopharmaceutical Processes
Chromatography, Bioconjugation, and Protein Stability
 , pp. 84 - 109
Publisher: Cambridge University Press
Print publication year: 2018

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