As of 2016, almost all states retain religious exemption statutes related to childhood vaccination and school immunization, part of a larger movement to accommodate devout believers whose faith requires their undivided conviction in the healing powers of a higher being.  For strict adherents, this manifests itself in the form of “prayer healing.”   This chapter offers arguments explaining why religious exemptions undermine the state’s legitimate interest in the well-being of its most vulnerable citizens—children.  The chapter explores certain idiosyncratic influences that compel believers to withhold modern medicine for their ill-child, summarizes instances where a child, under the care of well-intentioned but ultimately negligent parents, is refused life-saving treatment, and documents instances where the child’s life could have been saved, but for the parent’s insistence on prayer-healing. The chapter also recommends repealing state statutes that provide medical exemptions for faith healing parents intent on praying for, rather than treating, their sick child, since such laws contravene the child’s fundamental right to life.