This chapter examines whether agnosticism with respect to personal ontology should lead us toward agnosticism with respect to the possibility of life after death. Two afterlife scenarios are considered: resurrection and reincarnation. It is argued that all the major accounts of personal ontology are compatible with both resurrection and reincarnation, except for the non-self thesis, which is incompatible with resurrection. Various arguments for the conclusion that resurrection or reincarnation are impossible are considered and rejected. But it is argued that reincarnation faces a difficulty: the standard evidence cited for reincarnation, namely the presence of mental states apparently from a previous life, would, even if corroborated, not show that one is identical with someone from a previous life. What’s more, it would not provide any evidence for substance dualism.