Book contents
- Capnography
- Capnography
- Copyright page
- Contents
- Contributors
- Preface
- Commonly used abbreviations
- 1 Clinical perspectives
- 1 Ventilation
- 2 Ventilation Capnography and respiratory assessment outside of the operating room
- 3 Airway management in the out-of-hospital setting
- 4 Airway management in the hospital setting
- 5 Airway management in the operating room
- 6 Capnography during anesthesia
- 7 Monitoring during mechanical ventilation
- 8 Capnography during transport of patients (inter/intrahospital)
- 9 Capnography as a guide to ventilation in the field
- 10 Neonatal monitoring
- 11 Capnography in sleep medicine
- 12 Conscious sedation
- 13 Capnometry monitoring in high- and low-pressure environments
- 14 Biofeedback
- 15 Capnography in non-invasive positive pressure ventilation
- 16 End-tidal carbon dioxide monitoring in postoperative ventilator weaning
- 17 Optimizing the use of mechanical ventilation and minimizing its requirement with capnography
- 18 Volumetric capnography for monitoring lung recruitment and PEEP titration
- 19 Capnography and adjuncts of mechanical ventilation
- 20 Cardiopulmonary resuscitation
- 21 Capnography and pulmonary embolism
- 22 Non-invasive cardiac output via pulmonary blood flow
- 23 PaCO2, PetCO2, and gradient
- 24 The physiologic basis for capnometric monitoring in shock
- 25 Carbon dioxide production, metabolism, and anesthesia
- 26 Tissue- and organ-specific effects of carbon dioxide
- 27 Atmospheric monitoring outside the healthcare environment and within enclosed environments: a historical perspective
- 28 Capnography in veterinary medicine
- 29 Carbon dioxide pathophysiology
- 30 Acid–base balance and diagnosis of disorders
- 31 Ventilation/perfusion abnormalities and capnography
- 32 Capnographic measures
- 33 Improving the analysis of volumetric capnograms
- 34 Capnography and the single-path model applied to cardiac output recovery and airway structure and function
- 35 Carbon dioxide and the control of breathing: a quantitative approach
- 36 Technical specifications and standards
- 37 Carbon dioxide measurement
- 38 Gas flow measurement
- 39 Combining flow and carbon dioxide
- 40 Brief history of time and volumetric capnography
- 41 The first years of clinical capnography
- 42 The early days of volumetric capnography
- Appendix: Patterns of time-based capnograms
- Index
26 - Tissue- and organ-specific effects of carbon dioxide
from 1 - Ventilation
Published online by Cambridge University Press: 05 August 2011
Book contents
- Capnography
- Capnography
- Copyright page
- Contents
- Contributors
- Preface
- Commonly used abbreviations
- 1 Clinical perspectives
- 1 Ventilation
- 2 Ventilation Capnography and respiratory assessment outside of the operating room
- 3 Airway management in the out-of-hospital setting
- 4 Airway management in the hospital setting
- 5 Airway management in the operating room
- 6 Capnography during anesthesia
- 7 Monitoring during mechanical ventilation
- 8 Capnography during transport of patients (inter/intrahospital)
- 9 Capnography as a guide to ventilation in the field
- 10 Neonatal monitoring
- 11 Capnography in sleep medicine
- 12 Conscious sedation
- 13 Capnometry monitoring in high- and low-pressure environments
- 14 Biofeedback
- 15 Capnography in non-invasive positive pressure ventilation
- 16 End-tidal carbon dioxide monitoring in postoperative ventilator weaning
- 17 Optimizing the use of mechanical ventilation and minimizing its requirement with capnography
- 18 Volumetric capnography for monitoring lung recruitment and PEEP titration
- 19 Capnography and adjuncts of mechanical ventilation
- 20 Cardiopulmonary resuscitation
- 21 Capnography and pulmonary embolism
- 22 Non-invasive cardiac output via pulmonary blood flow
- 23 PaCO2, PetCO2, and gradient
- 24 The physiologic basis for capnometric monitoring in shock
- 25 Carbon dioxide production, metabolism, and anesthesia
- 26 Tissue- and organ-specific effects of carbon dioxide
- 27 Atmospheric monitoring outside the healthcare environment and within enclosed environments: a historical perspective
- 28 Capnography in veterinary medicine
- 29 Carbon dioxide pathophysiology
- 30 Acid–base balance and diagnosis of disorders
- 31 Ventilation/perfusion abnormalities and capnography
- 32 Capnographic measures
- 33 Improving the analysis of volumetric capnograms
- 34 Capnography and the single-path model applied to cardiac output recovery and airway structure and function
- 35 Carbon dioxide and the control of breathing: a quantitative approach
- 36 Technical specifications and standards
- 37 Carbon dioxide measurement
- 38 Gas flow measurement
- 39 Combining flow and carbon dioxide
- 40 Brief history of time and volumetric capnography
- 41 The first years of clinical capnography
- 42 The early days of volumetric capnography
- Appendix: Patterns of time-based capnograms
- Index
Summary
This chapter focuses on the effects of hypo- and hypercapnia at the organ and tissue level. Carbon dioxide's role in determining acid-base status and tissue oxygenation is described, followed by its effects on major organ systems. The higher lipid solubility of CO2 compared to hydrogen ions allows acid-base changes caused by respiratory acidosis and alkalosis to equilibrate between extra- and intracellular fluids much faster than changes caused by metabolic acidosis or alkalosis. The primary determinants of tissue oxygen availability are arterial O2 tension, cardiac output, and local perfusion. Hypocapnia induced by hyperventilation is clinically used for treatment of increased intracranial pressure (ICP), but the compromise in tissue perfusion, and thus the resulting secondary ischemia, should be factored into the risk-benefit equation. The active management of CO2 is a promising strategy to consider for improving tissue perfusion, providing anti-inflammatory effects, and preventing apoptotic injury.
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- Capnography , pp. 250 - 258Publisher: Cambridge University PressPrint publication year: 2011