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Prefrontal Theta Cordance in the Prediction of Antidepressant Response to Various Classes of Antidepressants in Patients with Depressive Disorder
Published online by Cambridge University Press: 23 March 2020
Abstract
Introduction and objectives
Previous studies demonstrated efficacy of reduction of QEEG prefrontal theta cordance (RC) after the first week of treatment in the prediction of antidepressant response.
Aims
The study aimed to compare the ability of RC in the prediction of response to various antidepressant classes.
Methods
All patients (n = 142) were treated with antidepressants (SSRI-58, SNRI-47, NDRI-22, NaSSA-15) for ≥ 4 weeks. Response was defined as MADRS reduction ≥ 50%. EEG were performed at baseline and week 1 of treatment and cordance was calculated for 3 prefrontal electrodes (Fp1, Fp2, Fz).
Results
Logistic regression identified RC as a predictor of response to SSRI, SNRI and NDRI but not for NaSSA. Predictive parameters of RC for response to mentioned antidepressant classes are displayed in the Table 1.
Areas under curves of ROC analysis (AUC) of RC for response prediction were not significantly different among antidepressant classes.
Conclusion
The predictive efficacy of RC for response to SSRI, SNRI and NDRI was comparable.
This study was supported by the grants of MH CZ nr.15-29900A, MH CZ – DRO (NIMH-CZ, 00023752) and by the project Nr. LO1611 from the MEYS under the NPU I program.
- Type
- e-Poster walk: Depression–part 1
- Information
- European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. s140
- Copyright
- Copyright © European Psychiatric Association 2017
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