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Antioxidant effects of rosemary (Rosmarinus officinalis L.) extract on bone metabolism in rats

Published online by Cambridge University Press:  23 September 2015

L.A. Almousa  and
D.M. Alnori
L.A. Almousa
Affiliation:
Department of Nutrition and Foods science, Princess Nora Bint Abdulrahman University, Kingdom of Saudi Arabia
D.M. Alnori
Affiliation:
Department of Food Sciences and Nutrition, King Saud University, Kingdom of Saudi Arabia
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Abstract

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Proceedings of the Nutrition Society , Volume 74 , Issue OCE5: Summer Meeting, 6–9 July 2015, The future of animal products in the human diet: health and environmental concerns , 2015 , E336
Copyright
Copyright © The Authors 2015 

For centuries, various herbs have been used to cure many diseases because they have numerous antioxidant,( Reference Abu-Al-Basal 1 ) anti-inflammatory and antibacterial properties, and some even promote anti-proliferation activities against several human cancer cell lines( Reference Zegura, Dobnik and Nideral 2 ). Rosemary (Rosmarinus officinalis L.) extract is a natural antioxidant and has a high concentration of biologically active substance such as phenols, caffeoyl, and flavones( Reference Hussain, Anwar and Chatha 3 ). The present study investigates the effects of rosemary (Rosmarinus officinalis L.) leaf extract on the bone metabolism of rats.

Adult Wistar rats (n = 18) were assigned to one of three treatment groups. Group A served as a control, group B was treated with cold aqueous extract 1·3 ml oral gavages once a day, and group C was treated with hot aqueous extract 1·3 ml oral gavages once a day. The rats were treated for thirty days. The total antioxidant power and alkaline phosphatase enzyme were measured in the plasma at the end of the experiment. Then, the rats were euthanized, and bone (femur) was removed promptly and analyzed for calcium and phosphorous. The results showed that the oral gavages of rosemary extract increased the levels of total antioxidants and alkaline phosphatase in the treated groups (data not shown).

Post hoc analysis showed that significant increase in group C compared with group A (Fig. 1, P < 0·049) (Fig. 2, P < 0·016). The results of the present study indicate that rosemary improves bone metabolism.

Fig. 1. Calcium percentage in left femur

Fig. 2. Phosphorous percentage in left femur

References

1. Abu-Al-Basal, M (2010) J Ethnopharmacol 131, 443–450.Google Scholar
2. Zegura, B, Dobnik, D, Nideral, M et al. (2011) Environ Toxicol Pharmacol j 32, 296–305.Google Scholar
3. Hussain, A, Anwar, F, Chatha, S et al. (2010) Braz J Microbiol 41, 1070–1078.Google Scholar
Figure 0

Fig. 1. Calcium percentage in left femur

Figure 1

Fig. 2. Phosphorous percentage in left femur