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Structure Versus Metabolic Activities of Amitrole and Its Analogs

Published online by Cambridge University Press:  12 June 2017

James L. Hilton  and
Donald D. Kaufman
James L. Hilton
Affiliation:
Crops Research Division, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland
Donald D. Kaufman
Affiliation:
Crops Research Division, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland
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Abstract

Growth of Salmonella typhimurium LT-2 (Loeffler) Cast. and Chalm. was inhibited by 3-amino-l,2,4-triazole (amitrole), and 3-hydroxy-1,2,4-triazole, 3-chloro-l,2,4-triazole, and 5-amino-1,2,3,4-tetrazole (hereinafter referred to respectively as hydroxytriazole, chlorotriazole, and aminotetrazole). Toxicity of 2 × 10−2 M amitrole was partially overcome by 2 × 10−4 M histidine, and more effectively circumvented by combinations of histidine with 2 × 10−4 M adenine, 2 × 10−4 M riboflavin, or 2 × 10−4 M methionine. Serine reduced toxicity of 10−1 M amitrole when combined with both histidine and adenine but was less effective than methionine. Hydroxytriazole inhibition was partially overcome by adenine or less effectively by histidine but not by riboflavin, methionine, or serine. Chlorotriazole and aminotetrazole inhibitions were circumvented by 2 × 10−4 M methionine, 10−3 M serine, and 10−4 M cysteine but not by histidine, adenine, or riboflavin. The toxicity of high concentrations (10−3 M) of cysteine was reduced by chlorotriazole and aminotetrazole.

Type
Research Article
Information
Weed Science , Volume 16 , Issue 2 , April 1968 , pp. 152 - 158
Copyright
Copyright © Weed Science Society of America 

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References

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