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Physical activity and health, novel concepts and new targets: report from the 12th Conference of the International Research Group on the Biochemistry of Exercise

Published online by Cambridge University Press:  05 March 2007

Matthijs K. C. Hesselink  and
Marleen A. van Baak
Matthijs K. C. Hesselink*
Affiliation:
Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Departments of Movement Sciences, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands
Marleen A. van Baak
Affiliation:
Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Human Biology, Maastricht University, PO Box 616, 6200, MD, Maastricht, The Netherlands
*
*Corresponding author: Dr Matthijs K. C. Hesselink Fax: +31 43 3670972, Email: matthijs.hesselink@bw.unimaas.nl
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Abstract

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The present paper is the introductory paper to a series of brief reviews representing the proceedings of a recent conference on ‘The biochemical basis for the health effects of exercise’ organized by the International Research Group on the Biochemistry of Exercise in conjunction with the Nutrition Society. Here the aim is to briefly review and highlight the main innovations presented during this meeting. The following topics were covered during the meeting: exercise signalling pathways controlling fuel oxidation during and after exercise; the fatty acid transporters of skeletal muscle; mechanisms involved in exercise-induced mitochondrial biogenesis in skeletal muscle; new methodologies and insights in the regulation of fat metabolism during exercise; muscle hypertrophy: the signals of insulin, amino acids and exercise; adipose tissue–liver–muscle interactions leading to insulin resistance. In these symposia state-of-the-art knowledge on how physical exercise exerts its effects on health was presented. The fast-growing number of identified pathways and processes involved in the health effects of physical exercise, which were discussed during the meeting, will help to develop tailored physical-activity regimens in the prevention of inactivity-induced deterioration of health.

Keywords

Physical activityHealth
Type
Conference on ‘The biochemical basis of the health effects of exercise’
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 2 , May 2004 , pp. 189 - 197
Copyright
Copyright © The Nutrition Society 2004

References

Baar, K (2004) Involvement of PPARγ co-activator-1, nuclear respiratory factors 1 and 2, and PPARα in the adaptive response to endurance exercise. Proceedings of the Nutrition Society 63, 269–273.Google Scholar
Blaak, EE (2004) Basic disturbances in skeletal muscle fatty acid metabolism in obesity and type 2 diabetes mellitus. Proceedings of the Nutrition Society 63, 323–330.Google Scholar
Bolster, DR, Jefferson, LS & Kimball, SR (2004) Regulation of protein synthesis associated with skeletal muscle hypertrophy by insulin-, amino acid- and exercise-induced signalling. Proceedings of the Nutrition Society 63, 351–356.Google Scholar
Bonen, A, Campbell, SE, Benton, CR, Chabowski, A, Coort, SLM, Han, X-X, Koonen, DPY, Glatz, JFC & Luiken, JJFP (2004) Regulation of fatty acid transport by fatty acid translocase/CD36. Proceedings of the Nutrition Society 63, 245–249.Google Scholar
Booth, FW & Shanely, RA (2004) The biochemical basis of the health effects of exercise: an integrative view. Proceedings of the Nutrition Society 63, 199–203.Google Scholar
Chin, ER (2004) The role of calcium ions and the calcium ion/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. Proceedings of the Nutrition Society 63, 277–286.Google Scholar
Donsmark, H, Langfort, J, Holm, C, Ploug, T & Galbo, H (2004) Regulation and role of hormone-sensitive lipase in rat skeletal muscle. Proceedings of the Nutrition Society 63, 307–312.Google Scholar
Fujii, N, Aschenbach, WG, Musi, N, Hirshman, MF & Goodyear, LJ (2004) Regulation of glucose transport by the AMP-activated protein kinase. Proceedings of the Nutrition Society 63, 205–210.Google Scholar
Hargreaves, M (2004) Muscle glycogen and metabolic regulation. Proceedings of the Nutrition Society 63, 217–220.Google Scholar
Hood, DA & Joseph, A-M (2004) Mitochondrial assembly: protein import. Proceedings of the Nutrition Society 63, 293–300.Google Scholar
Hornberger, TA & Esser, KA (2004) Mechano-transduction and the regulation of protein synthesis in skeletal muscle. Proceedings of the Nutrition Society 63, 331–335.Google Scholar
Hulver, MW & Dohm, GL (2004) The molecular mechanism linking muscle fat accumulation to insulin resistance. Proceedings of the Nutrition Society 63, 375–380.CrossRefGoogle ScholarPubMed
Long, YC, Widegren, U & Zierath, JR (2004) Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle. Proceedings of the Nutrition Society 63, 227–232.Google Scholar
Luiken, JJFP, Coort, SLM, Koonen, DPY, Bonen, A & Glatz, JFC (2004) Signalling components involved in contraction-inducible substrate uptake into cardiac myocytes. Proceedings of the Nutrition Society 63, 251–258.Google Scholar
Machida, S & Booth, FW (2004) Insulin-like growth factor-1 and muscle growth: implication for satellite cell proliferation. Proceedings of the Nutrition Society 63, 337–340.Google Scholar
Michel, RN, Dunn, SE & Chin, ER (2004) Calcineurin and skeletal muscle growth. Proceedings of the Nutrition Society 63, 341–349.Google Scholar
Neel, JV (1962) Diabetes mellitus: a ‘thrifty’ genotype rendered detrimental by ‘progress’. American Journal of Human Genetics 14, 353–362.Google Scholar
Nielsen, JN & Wojtaszewski, JFP (2004) Regulation of glycogen synthase activity and phosphorylation by exercise. Proceedings of the Nutrition Society 63, 233–237.Google Scholar
Ojuka, EO (2004) Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. Proceedings of the Nutrition Society 63, 275–278.Google Scholar
Pedersen, BK, Steensberg, A, Fischer, C, Keller, C, Keller, P, Plomgaard, P Wolsk-Petersen, E & Febbraio, M (2004) The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor. Proceedings of the Nutrition Society 63, 263–267.Google Scholar
Pilegaard, H & Neufer, PD (2004) Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise. Proceedings of the Nutrition Society 63, 221–226.Google Scholar
Pohl, J, Ring, A, Ehehalt, R, Herrmann, T & Stremmel, W (2004) New concepts of cellular fatty acid uptake: role of fatty acid transport proteins and of caveolae. Proceedings of the Nutrition Society 63, 259–262.Google Scholar
Richter, EA, Nielsen, JN Jørgensen, SB, Frøsig, C, Birk, JB & Wojtaszewski, JFP (2004) Exercise signalling to glucose transport in skeletal muscle. Proceedings of the Nutrition Society 63, 211–216.Google Scholar
Roepstorff, C, Wulff Helge, J, Vistisen, B & Kiens, B (2004) Studies of plasma membrane fatty acid-binding protein and other lipid-binding proteins in human skeletal muscle. Proceedings of the Nutrition Society 63, 239–244.Google Scholar
Schrauwen, P & Hesselink, MKC (2004) The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity. Proceedings of the Nutrition Society 63, 287–292.Google Scholar
Stich, V & Berlan, M (2004) Physiological regulation of NEFA availability: lipolysis pathway. Proceedings of the Nutrition Society 63, 369–374.Google Scholar
Storlien, L, Oakes, ND & Kelley, DE (2004) Metabolic flexibility. Proceedings of the Nutrition Society 63, 363–368.CrossRefGoogle ScholarPubMed
Taillandier, D, Combaret, L, Pouch, M-N, Samuels, SE, Béchet, D & Attaix, D (2004) The role of ubiquitin–proteasome-dependent proteolysis in the remodelling of skeletal muscle. Proceedings of the Nutrition Society 63, 357–361.Google Scholar
Tomas, E, Kelly, M Xiaoqin Xiang, K, Tsao, T-S, Keller, C, Keller, P, Luo, Z, Lodish, H, Saha, AK, Unger, R & Ruderman, NB (2004) Metabolic and hormonal interactions between muscle and adipose tissue. Proceedings of the Nutrition Society 63, 381–385.CrossRefGoogle ScholarPubMed
Watt, MJ & Spriet, LL (2004) Regulation and role of hormone-sensitive lipase activity in human skeletal muscle. Proceedings of the Nutrition Society 63, 315–322.Google Scholar
World Health Organization (2002) The world health report: Reducing risks and promoting healthy life. http://www.who.int/whr/2002Google Scholar
World Health Organization (2003) Global strategy on diet, physical activity and health. http://www.who.int/hpr/global.strategy.shtmlGoogle Scholar