Hostname: page-component-7479d7b7d-c9gpj Total loading time: 0 Render date: 2024-07-12T03:25:56.988Z Has data issue: false hasContentIssue false

Phospholipase A2 (EC 3.1.1.4) and D (EC 3.1.4.4) signalling in lymphocytes

Published online by Cambridge University Press:  18 April 2008

Michael J. O. Wakelam*
Affiliation:
Institute for Cancer Studies, Birmingham University Medical School, Birmingham B15 2TA, UK
Margaret M. Harnett
Affiliation:
Department of Immunology, Glasgow University, Glasgow G12 8QQ, UK
*
*Corresponding author: Professor Michael J. 0. Wakelam, fax +44 (0)121 414 5263, email M.J.O.Wakelam@bham.ac.uk
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Meeting Report
Copyright
Copyright © The Nutrition Society 1998

References

Berlin, RD & Preston, SF (1995) Arachidonic acid mobilization is suppressed during mitosis: Role of cytosolic phospholipase A2 activation. Biochemical Journal 309, 9197.CrossRefGoogle ScholarPubMed
Courtney, C-A, Stewart, A, Wakelam, MJO & Harnett, MM (1993) The antigen receptors on B and T cells are not coupled to cytosolic phospholipase A2 activation and arachidonic acid release. Biochemical Society Transactions 21, 496.CrossRefGoogle Scholar
Cross, MJ, Roberts, S, Ridley, AJ, Hodgkin, MN, Stewart, A, Claesson-Welsh, L & Wakelam, MJO (1996) Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Current Biology 6, 588597.CrossRefGoogle ScholarPubMed
Gilbert, JJ, Stewart, A, Courtney, C-A, Fleming, M-C, Reid, PA, Jackson, CG, Wise, A, Wakelam, MJ & Harnett, MM (1996) The antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic A2 correlate with lymphocyte maturation. Journal of Immunology 156, 20542062.CrossRefGoogle ScholarPubMed
Gilbert, JJ, Wakelam, MJO & Harnett, MM (1993) A role for phospholipase D activation in B cell activation. Biochemical Society Transactions 21, 493.CrossRefGoogle ScholarPubMed
Jayadev, S, Linardic, LM & Hannun, YA (1994) Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor. Journal of Biological Chemistry 269, 55575562.CrossRefGoogle ScholarPubMed
Kim, BC & Kim, JH (1997) Nuclear signalling by Rac GTPase: essential role of phospholipase A2. Biochemical Journal 326, 333337.CrossRefGoogle ScholarPubMed
Mollinedo, F, Gajate, C & Flores, I (1994) Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells. Journal of Immunology 153, 24572461.CrossRefGoogle ScholarPubMed
Neale, ML, Fiera, RA & Matthews, N (1988) Involvement of phospholipase A2 activation in tumor cell killing by tumor necrosis factor. Immunology 64, 8184.Google Scholar
Olivier, AR, Hansra, G, Pettitt, TR, Wakelam, MJO & Parker, PJ (1996) The co-mitogenic combination of transforming growth factor β1 and bombesin protects protein kinase C-γ from late-phase down-regulation despite synergy in diacylglycerol accumulation. Biochemical Journal 318, 519525.CrossRefGoogle Scholar
Pao, L, Carbone, AM & Cambier, JC (1997) Antigen receptor structure and signalling in B cells. In Lymphocyte Signalling, pp. 329 [Harnett, MM and Rigley, KP, editors]. Chichester, W. Sussex: John Wiley & Sons.Google Scholar
Pettitt, TR, Martin, A, Horton, T, Liossis, C, Lord, J & Wakelam, MJO (1997) Diacylglycerol and phosphatidate generated by phospholipases C and D respectively have distinct fatty acid compositions and functions: phospholipase D-derived diacylglycerol does not activate protein kinase C in PAE cells. Journal of Biological Chemistry 272, 1735417359.CrossRefGoogle Scholar
Pettitt, TR & Wakelam, MJO (1993) Bombesin stimulates distinct time-dependent changes in the sn-1,2-diradylglycerol molecular species profile from Swiss 3T3 fibroblasts as analysed by 3,5-dinitrobenzoyl derivatisation and HPLC separation. Biochemical Journal 289, 487495.CrossRefGoogle Scholar
Pettitt, TR, Zaqqa, M & Wakelam, MJO (1994) Epidermal growth actor stimulates distinct diradylglycerol species generation in Swiss 3T3 fibroblasts: Evidence for a potential phosphatidylcholine-phospholipase C-catalysed pathway. Biochemical Journal 298, 655660.CrossRefGoogle Scholar
Reid, PA, Gardner, SD, Williams, D & Harnett, MM (1997) The antigen receptors on mature and immature T lymphocytes are coupled to phosphatidylcholine-specific phospholipase D activation. Immunology 90, 250256.CrossRefGoogle ScholarPubMed
Stewart, SJ, Cunningham, G & House, FS (1993) Activation of phospholipase-D following perturbation of the human T-lymphocyte antigen receptor/CD3 complex is dependent upon protein kinase-C. Cellular Signalling 5, 315323.CrossRefGoogle ScholarPubMed
Stewart, SJ, Cunningham, GR, Strupp, JA, House, FS, Kelley, LL, Henderson, GS, Exton, J & Bocckino, S (1991) Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex. Cell Regulation 2, 841845.CrossRefGoogle ScholarPubMed
Taylor-fishwick, DA, June, CH & Siegel, JN (1997) Antigen receptor structure and signalling in T cells. In Lymphocyte Signalling, pp. 3152 [Harnett, MM and Rigley, Kp, editors]. Chichester, W. Sussex: John Wiley & Son.Google Scholar
VoelkelJohnson, C, Thome, TE & Laster, SM (1996) Susceptibility to TNF in the presence of inhibitors of transcription or translation is dependent on the activity of cytosolic phospholipase A2 in human melanoma tumor cells. Journal of Immunology 156, 201207.CrossRefGoogle ScholarPubMed
Waite, KA, Wallin, R, Qualliotine-Mann, D & McPhail, LC (1997) Phosphatidic acid-mediated phosphorylation of the NADPH oxidase component p47-phox. Journal of Biological Chemistry 272, 1556915578.CrossRefGoogle ScholarPubMed
Wakelam, MJO (1994) An overview of the regulation of phospholipase-linked cell signalling. In New Targetsfor Cancer Chemotherapy, pp. 3144 [Kerr, DJ and Workman, P, editors]. Boca Raton, FL: CRC Press.Google Scholar
Wakelam, MJO, Hodgkin, MN, Martin, A & Saqib, K (1997) Phospholipase D. Seminars in Cell and Developmental Biology 8: 305311.CrossRefGoogle ScholarPubMed