Skip to main content Accessibility help
×
Home
Hostname: page-component-cf9d5c678-p4zth Total loading time: 0.227 Render date: 2021-08-01T18:31:29.301Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

A new n-3 PUFA-enriched formula for enteral nutrition modulates oxidative LDL and inflammatory cytokines

Published online by Cambridge University Press:  12 May 2008

J. Olza
Affiliation:
Institute of Nutrition and Food Technology, Dept of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
R. Moreno
Affiliation:
Universitary Hospital Virgen de las Nieves, Unit of Clinical Nutrition and Dietetic, Granada, Spain
C. M. Aguilera
Affiliation:
Institute of Nutrition and Food Technology, Dept of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
A. Pérez de la Cruz
Affiliation:
Universitary Hospital Virgen de las Nieves, Unit of Clinical Nutrition and Dietetic, Granada, Spain
A. Gil
Affiliation:
Institute of Nutrition and Food Technology, Dept of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
M. D. Mesa
Affiliation:
Institute of Nutrition and Food Technology, Dept of Biochemistry and Molecular Biology II, University of Granada, Granada, Spain
Rights & Permissions[Opens in a new window]

Abstract

Type
1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
Copyright
Copyright © The Authors 2008

Aging is associated with chronic low-grade increases in circulating levels of inflammatory molecules. A wide range of factors including obesity, metabolic syndrome, CVD, infection, smoking, genetic and declining function of sex hormones may contribute to the systemic low-grade increase in inflammatory activity in the elderly. Circulating TNFα is a good predictor of mortality in the frail elderly population and the oxidation of LDL can be a consequence of the secretion of cytokines and adhesion molecules during the inflammatory process. Dietary interventions may be good strategies to decrease pro-inflammatory activity and improve human health. It is well known that long-chain n-3 PUFA decrease the production of inflammatory cytokines. The aim of the present study was to compare the effect of T-Diet Plus® v. a standard control diet on plasma concentrations of inflammatory markers and oxidized LDL (ox-LDL) in elderly patients feed total enteral nutrition (TEN) for 6 months.

Sixty-five patients aged 75 years feed TEN were divided into two groups (experimental and reference). The experimental group (n 32) was fed a new enteral formula, T-Diet Plus® (Vegenat SA), that contained (mg/l) 75 EPA and 35 DHA. Reference group (n 33) was fed a standard enteral diet (Jevity®, Abbot Laboratories) intended for nutrition in the elderly. At the end of the experimental period only sixteen patients from the T-Diet Plus® group and twenty from the reference group remained in the study. The daily intake was 5459 (se 130) kJ, with no difference between groups. Cytokines (basal, 3 months and 6 months) were measured using a human serum adipokine (panel B) kit (LINCOplex™; Linco Research, St Charles, MO, USA) with the Luminex 200 System built on xMAP technology. Ox-LDL was determined using an ELISA kit (Biomedica Medizinprodukte GmbH & Co KG, Vienna, Austria) and the ultra-sensitive C-reactive protein (PCRus) with a turbidimetric immunoassay (Dade Behring Inc., Deerfield, IL, USA). Non-parametric tests were used for statistical analysis: Mann-Witney test was performed to evaluate differences between independent groups (P⩽0.05); Wilcoxon test was used to determine the effect of each diet after 3 or 6 months (mean values with unlike superscript letters were significantly different: P⩽0.05).

The results demonstrate that ox-LDL decreased after 6 months of monitored nutrition in both groups (P⩽0.05), with no differences between groups. No differences were found in other inflammatory markers, although both TNFα and IL-6 showed a tendency to decrease after 6 months, which is important considering that the patients were frail elderly with different pathologies.

This study was financed by Vegenat SA.

You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

A new n-3 PUFA-enriched formula for enteral nutrition modulates oxidative LDL and inflammatory cytokines
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

A new n-3 PUFA-enriched formula for enteral nutrition modulates oxidative LDL and inflammatory cytokines
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

A new n-3 PUFA-enriched formula for enteral nutrition modulates oxidative LDL and inflammatory cytokines
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *