Skip to main content Accessibility help
×
Home
Hostname: page-component-564cf476b6-z65vl Total loading time: 0.435 Render date: 2021-06-18T15:50:30.836Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Do lean markers relate to exacerbation rate in chronic obstructive pulmonary disease? Preliminary results from AERIS study

Published online by Cambridge University Press:  22 April 2015

M. M. Wojtas
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK NIHR Southampton Biomedical Research Centre, Southampton, SO16 6YD UK
S. Wootton
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK NIHR Southampton Biomedical Research Centre, Southampton, SO16 6YD UK
A. Barton
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton, SO16 6YD UK NIHR Southampton Biomedical Research Centre, Southampton, SO16 6YD UK
V. Kim
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK
K. Ostridge
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK
N. Williams
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK
E. Aris
Affiliation:
GlaxoSmithKline Vaccines, Rixensart, Belgium
M. Peeters
Affiliation:
GlaxoSmithKline Vaccines, Rixensart, Belgium
J. M. Devaster
Affiliation:
GlaxoSmithKline Vaccines, Rixensart, Belgium
S. Bourne
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK
T. Wilkinson
Affiliation:
University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton, SO16 6YD UK Faculty of Medicine, University of Southampton, Southampton, SO16 6YD UK
Rights & Permissions[Opens in a new window]

Abstract

Type
Abstract
Copyright
Copyright © The Authors 2015 

Previous studies suggested body composition may be related to COPD progression( Reference Vilaro, Ramirez-Sarmiento and Martinez-Llorens 1 ) however no definitive studies link lean markers (muscle mass or function) to exacerbation frequency( Reference Donaldson, Maddocks and Martolini 2 ). We aimed to investigate this relationship.

An initial cohort of 36 stable COPD subjects (GOLD 2–4) from the AERIS( Reference Bourne, Cohet and Kim 3 ) study was analysed. Fat free mass (FFM) was assessed by bioelectrical impedance and function with grip strength (GS), grip endurance (GE) and six minute walk test (6MWT). FFM, impedance at 50kHz (Imp50) and GS were adjusted for height and presented as indexes (i). Frequency of exacerbations was prospectively recorded for 12 months and adjusted for length of follow up. A rate of >0·17 exacerbation/month (i.e. ⩾2 exacerbations/year) indicated frequent exacerbators. Schols lean depletion cutoffs (FFMi <16 male, <15 female kg/m2) were applied.

75% (27) subjects were defined as frequent exacerbators: 53% moderate, 88% severe and 100% very severe COPD subjects. COPD severity and exacerbation rates were similar between genders (0·3 exacerbations/month).

Women had significantly lower weight, FFM, FFMi, GS and GSi but higher Imp50 and Imp50i than men (all p < 0·05). In women alone, FEV1% was significantly related to FFMi (r = 0·52) and to 6MWT (r = 0·61). FFMi, GS, GSi and GE were significantly related to 6MWT (r = 0·49; 0·81; 0·72; 0·49 respectively).

There were no statistical significant differences for FFM, FFMi, GE, GS, GSi, Imp50, Imp50i, or 6MWT between the frequent and nonfrequent exacerbator groups for either men or women. For men, there could be a trend towards frequent exacerbators for low 6MWT and high IMP50 values. Using Schols criteria 36% of subjects (2 male, 11 female) were lean deplete, and the exacerbation rates were similar in the 2 subgroups.

Our preliminary results do not provide evidence that FFMi, Imp50, GS or 6MWT are associated with a higher frequency of exacerbation, however Imp50 and 6MWT in men may have predictive value. Lack of statistical significance may be due to the small sample size and high proportion of frequent exacerbators. Further analysis of the full AERIS cohort may yield more information on the predictive value of lean markers on exacerbation frequency and treatment response.

References

1. Vilaro, J, Ramirez-Sarmiento, A, Martinez-Llorens, JM et al. (2010) Respir Med 104, 18961902.CrossRefGoogle Scholar
2. Donaldson, AV, Maddocks, M, Martolini, D et al. (2012) Int J Chron Obstruct Pulmon Dis 7, 523–35.Google Scholar
3. Bourne, S, Cohet, C., Kim, V et al. (2014). BMJ Open, 4, e004546.CrossRefGoogle Scholar
You have Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Do lean markers relate to exacerbation rate in chronic obstructive pulmonary disease? Preliminary results from AERIS study
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Do lean markers relate to exacerbation rate in chronic obstructive pulmonary disease? Preliminary results from AERIS study
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Do lean markers relate to exacerbation rate in chronic obstructive pulmonary disease? Preliminary results from AERIS study
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *