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Antioxidants and lipoprotein metabolism

Published online by Cambridge University Press:  28 February 2007

Mridula Chopra  and
David I. Thurnham
Mridula Chopra*
Affiliation:
Northern Ireland Centre for Diet and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
David I. Thurnham
Affiliation:
Northern Ireland Centre for Diet and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
*
*Corresponding Author: Dr Mridula Chopra, fax +44 (0)1265 324965, email m.chopra@ulst.ac.uk
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Abstract

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Lipoprotein metabolism plays a significant role in the pathogenesis of atherosclerosis and risk of vascular disease. Elevated levels of LDL and low levels of HDL are linked to the risk of cardiovascular disease. It is now widely accepted that oxidative modification of LDL affects the metabolism of lipoproteins, leading to their increased accumulation in arterial intima. The present paper will examine some of the accumulating evidence from studies showing relationships between dietary intake of antioxidant nutrients, i.e. vitamins E and C, the carotenoids and the flavonoids, and their influence on lipoprotein metabolism. In particular, the present paper will review the available literature on the affect of antioxidant supplementation on lipoprotein oxidation, and hence metabolism of LDL in human subjects.

Keywords

LipoproteinsAntioxidantsVitaminsFlavonoids
Type
Clinical Nutrition and Metabolism Group Symposium on ‘Nutrition and antioxidants’
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 3 , August 1999 , pp. 663 - 671
Copyright
Copyright © The Nutrition Society 1999

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