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Synthesis and X-ray diffraction data of (4R)-methyl-3-(1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carbonyl)thiazolidin-4-carboxylate, C14H13ClN4O3S

Published online by Cambridge University Press:  06 November 2019

Fausto M. Güiza ,
Arnold R. Romero Bohórquez ,
J. A. Henao  and
H. A. Camargo Open the ORCID record for H. A. Camargo [Opens in a new window]
Fausto M. Güiza
Affiliation:
Grupo de Investigación en Compuestos Orgánicos de Interés Medicinal (CODEIM), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
Arnold R. Romero Bohórquez
Affiliation:
Grupo de Investigación en Compuestos Orgánicos de Interés Medicinal (CODEIM), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
J. A. Henao
Affiliation:
Grupo de Investigación en Química Estructural (GIQUE), Escuela de Química, Facultad de Ciencias, Universidad Industrial de Santander, A.A. 678, Carrera 27, Calle 9 Ciudadela Universitaria, Bucaramanga, Colombia
H. A. Camargo*
Affiliation:
Grupo de Investigación en Nuevos Materiales y Energías Alternativas (GINMEA), Universidad Santo Tomás, Facultad de Química Ambiental, Campus Universitario Floridablanca, Santander, Colombia
*
a)Author to whom correspondence should be addressed. Electronic mail: hernando.camargo@ustabuca.edu.co
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Abstract

The new compound (4R)-methyl-3-(1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carbonyl)thiazolidin-4-carboxylate was synthesized by the 1,3-dipolar cycloaddition reaction between (4R)-methyl-3-propionyl-thiazolidin-4-carboxylate (1) and 4-chlorophenylazide using the click chemistry approach. Molecular characterization was carried out by infrared spectroscopy and mass spectrometry. The X-ray powder diffraction study determined that the title compound crystallized in an orthorhombic system with unit-cell parameters a = 20.876 (2) Å, b = 12.111 (1) Å, and c = 6.288 (9) Å. The volume of the unit cell is V = 1589.7 (2) Å3. All measured diffraction maxima were indexed and are consistent with the P2221 space group (No. 17). No detectable impurities were observed.

Keywords

thiazolidinesantineoplastic activityX-ray powder diffraction
Type
New Diffraction Data
Information
Powder Diffraction , Volume 35 , Issue 1 , March 2020 , pp. 41 - 44
Copyright
Copyright © International Centre for Diffraction Data 2019

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