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Structural characterization of a new form of clenbuterol, a well-known decongestant and bronchodilator also used as a performance-enhancing drug

Published online by Cambridge University Press:  16 April 2013

R. Toro ,
J. Bruno-Colmenárez ,
G. Díaz de Delgado  and
J.M. Delgado
R. Toro
Affiliation:
Laboratorio de Cristalografía-LNDRX, Departamento de Química, Universidad de Los Andes, Mérida, Venezuela
J. Bruno-Colmenárez
Affiliation:
Unidad de Caracterización Estructural de Materiales, Instituto Zuliano de Investigaciones Tecnológicas (INZIT), La Cañada, Zulia, Venezuela
G. Díaz de Delgado
Affiliation:
Laboratorio de Cristalografía-LNDRX, Departamento de Química, Universidad de Los Andes, Mérida, Venezuela
J.M. Delgado*
Affiliation:
Laboratorio de Cristalografía-LNDRX, Departamento de Química, Universidad de Los Andes, Mérida, Venezuela
*
a)Author to whom correspondence should be addressed. Electronic mail: migueld@ula.ve
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Abstract

Clenbuterol hydrochloride is an active pharmaceutical ingredient usually prescribed for treatment of respiratory diseases due to its activity as a decongestant and bronchodilator. It has also been used as a performance-enhancing drug. In the PDF-4/Organics 2012 database there are six entries related to this compound: three for its hydrochloride phase calculated using single-crystal data, two for a MeOH and a DMSO solvate of two Cu-clenbuterol complexes, and one experimental unindexed pattern. In this contribution the powder diffraction pattern and the crystal structure, determined using single crystal X-ray diffraction techniques of clenbuterol hemihydrate, C12H18Cl2N2O·0.5H2O, an unreported phase, are presented.

Keywords

clenbuterol hemihydratepowder diffractionsingle-crystal diffractioncrystal structuredecongestantbronchodilator
Type
Technical Articles
Information
Powder Diffraction , Volume 28 , Issue 2 , June 2013 , pp. 63 - 67
Copyright
Copyright © International Centre for Diffraction Data 2013 

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