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Variable expression of virulence in the rodent malaria parasite Plasmodium yoelii yoelii

Published online by Cambridge University Press:  06 April 2009

G. Knowles  and
D. Walliker
G. Knowles
Affiliation:
Institute of Animal Genetics, Kings Buildings, West Mains Road, Edinburgh EH9 3JN
D. Walliker
Affiliation:
Institute of Animal Genetics, Kings Buildings, West Mains Road, Edinburgh EH9 3JN
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Summary

The expression of the virulence character in the virulent line (YM) of Plasmodium yoelii yoelii was investigated. The level of virulence was measured by counting the parasitaemia of the mature red blood cells. Several sub-clones were isolated from the virulent line YM and each was tested for its level of virulence. Out of 10 sub-clones 1 showed a marked decrease in virulence. However, transmission of this sub-clone through mosquitoes fully restored its virulence. A clone isolated from the progeny of a cross between mild and virulent parents had an intermediate level of virulence. A sub-clone isolated from this intermediate virulent line exhibited greatly reduced virulence. Mosquito transmission of this sub-clone also restored its virulence to a level comparable with the virulent line YM.

Type
Research Article
Information
Parasitology , Volume 81 , Issue 1 , August 1980 , pp. 211 - 219
Copyright
Copyright © Cambridge University Press 1980

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