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Triphasic locomotor response of a plant-parasitic nematode to avermectin: inhibition by the GABA antagonists bicuculline and picrotoxin

Published online by Cambridge University Press:  06 April 2009

D. J. Wright ,
A. J. Birtle  and
I. T. J. Roberts
D. J. Wright
Affiliation:
Department of Pure and Applied Biology, Imperial College Silwood Park, Ashurst Lodge, Ascot, Berkshire SL5 7PY
A. J. Birtle
Affiliation:
Department of Pure and Applied Biology, Imperial College Silwood Park, Ashurst Lodge, Ascot, Berkshire SL5 7PY
I. T. J. Roberts
Affiliation:
Department of Pure and Applied Biology, Imperial College Silwood Park, Ashurst Lodge, Ascot, Berkshire SL5 7PY
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Summary

The response of the plant parasitic nematode, Meloidogyne incognita (J2 stage) to avermectin B2a-23-one is triphasic, comprising an initial loss of locomotor activity where the juveniles remain sensitive to touch, a recovery phase and a final loss of activity where the juveniles are relatively insensitive to touch. In contrast, the acetylcholinesterase inhibitor, oxamyl, causes initial hyperactivity of juveniles followed by a progressive decline in movement. The addition of bicuculline and to a lesser extent picrotoxin, both antagonists of γ-aminobutyric acid (GABA), blocks the action of avermectin on M. incognita.

Type
Research Article
Information
Parasitology , Volume 88 , Issue 2 , April 1984 , pp. 375 - 382
Copyright
Copyright © Cambridge University Press 1984

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