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A systematic review of anti-Entamoeba histolytica activity of medicinal plants published in the last 20 years

Published online by Cambridge University Press:  04 February 2021

Saeed Nezaratizade Open the ORCID record for Saeed Nezaratizade [Opens in a new window] ,
Nooshin Hashemi Open the ORCID record for Nooshin Hashemi [Opens in a new window] ,
Davood Ommi Open the ORCID record for Davood Ommi [Opens in a new window] ,
Ilkay Erdogan Orhan Open the ORCID record for Ilkay Erdogan Orhan [Opens in a new window]  and
Faham Khamesipour Open the ORCID record for Faham Khamesipour [Opens in a new window]
Saeed Nezaratizade
Affiliation:
Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Nooshin Hashemi
Affiliation:
School of Medicine, Bam University of Medical Sciences, Bam, Iran
Davood Ommi
Affiliation:
Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ilkay Erdogan Orhan
Affiliation:
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Faham Khamesipour*
Affiliation:
Shahid Beheshti University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Faham Khamesipour, E-mail: faham.khamesipour@yahoo.com
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Abstract

Amoebiasis has emerged as a major health problem worldwide. It is endemic in the present scenario is different and sub-tropical regions especially in Asia, Latin America and also in Africa. Causative of amoebiasis is a protozoan known as Entamoeba histolytica. We screened all the databases such as PubMed, Science Direct, Medline and Google Scholar by using the keywords ‘anti-Entamoeba histolytica activity of medicinal plants, anti-Entamoeba histolytica activity of herbal drugs, the anti-amoebic activity of natural drugs’. In the present study, we found 7861 articles, where all articles were screened for bias analysis and included 32 full-matching articles in total reporting the use of medicinal plants as a remedy for amoebiasis. Through these articles, we found 42 herbs having anti-amoebic activity. In bias analysis, we also found four articles under high bias risk. In our study, seven medicinal plants were concluded to possess the most potent anti-amoebic activity based on their IC50 value, which was less than 1 μg mL−1. On bias analysis, we found four articles with high bias risk, hence these studies can be repeated for better results.

Keywords

Anti-amoebic activityanti-Entamoeba histolytica activitymedicinal plantsPRISMA
Type
Review Article
Information
Parasitology , Volume 148 , Issue 6 , May 2021 , pp. 672 - 684
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Copyright
Copyright © The Author(s) 2021. Published by Cambridge University Press

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References

Agarwal, A, Kanekar, S, Sabat, S and Thamburaj, K (2016) Metronidazole-induced cerebellar toxicity. Neurology International 8, 6365.CrossRefGoogle ScholarPubMed
Al-Braiken, FA and Salem, HS (2008) Diagnosis of Entamoeba histolytica in symptomatic children, Jeddah City, Saudi Arabia. Egyptian Journal of Immunology 15, 85–92.Google ScholarPubMed
Alanis, AD, Fernando, C, Cedillo-Rivera, R and Meckes, M (2003) Antiprotozoan activity of the constituents of Rubus coriifolius. Phytotherapy Research 17, 681–682.CrossRefGoogle Scholar
American Academy of Pediatrics (2012) Amebiasis. In Kimberlin, DW, Brady, MT, Jackson, MA and Long, SS (eds), Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL: American Academy of Pediatrics, pp. 228–230.Google Scholar
Azadbakht, M, Chabra, A, Akbarabadi, AS, Motazedin, MH, Monadi, T and AKbari, F (2020) Anti-parasitic activity of some medicinal plants essential oils on Giardia lambia and Entamoeba histolytica, invitro. Research Journal of Pharmacognosy 1, 41–47.Google Scholar
Badry, A, Ali, KHA and Badry, Y (2010) Activity of Mentha longifolia and Ocimum basilicum against Entamoeba histolytica and Giardia duodenalis. Scientia Parasitologica 11, 109–117.Google Scholar
Bashyal, B, Li, L, Bains, T, Debnath, A and LaBarbera, DV (2017) Larrea tridentata: a novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri. PLoS Neglected Tropical Diseases 11, e0005832.CrossRefGoogle ScholarPubMed
Behnia, M, Haghighi, A, Komeilizadeh, H, Seyyed Tabaei, S and Abadi, A (2008) In vitro antiamoebic activity of Iranian Allium sativum in comparison with metronidazole against Entamoeba histolytica. Iranian Journal of Parasitology 3, 32–38.Google Scholar
Bendesky, A and Menéndez, D (2001) Metronidazol: una visión integral. Revista de la Facultad de Medicina de la UNAM 44, 255–259.Google Scholar
Bharti, N, Singh, S, Naqui, F and Azam, A (2006) Isolation and invitro anti-amoebic activity of iridois isolated from Kigelia pinnata. General Papers ARKIVOC x, 69–70.Google Scholar
Biswas, R, Dutta, PK, Achari, B, Bandopadhyay, D, Mishra, M, Pramanik, KC and Chatarjee, TK (2007) Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 14, 534–537.CrossRefGoogle ScholarPubMed
Boechat, N, Carvalho, AS, Salomão, K, Castro, SL, Araujo-Lima, CF, Mello, FV, Felzenszwalb, I, Aiub, CA, Conde, TR, Zamith, HP, Skupin, R and Haufe, G (2015) Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group. Memórias do Instituto Oswaldo Cruz 110, 492–499.CrossRefGoogle ScholarPubMed
Bohlson, SS, Fraser, DA and Tenner, AJ (2007) Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions. Molecular Immunology 44, 33–43.CrossRefGoogle ScholarPubMed
Bolanos, V, Martinez, AD, Soto, J, Rodriguez, MA, Camarillo, CL, Marchat, LA and Moreno, ER (2011) The flavonoid (-) – epicatechin affects cytoskeleton proteins and functions in E. histolytica. Journal of Proteomics 111, 74–85.CrossRefGoogle Scholar
Bolanos, V, Martinez, AD, Soto, J, Marchat, LA, Monroy, VS and Moreno, ER (2015) Kaempferol inhibits Entamoeba histolytica growth by altering cytoskeletal functions. Molecular and Biochemical Parasitology 204, 16–25.CrossRefGoogle ScholarPubMed
Calzada, F (2005) Additional anti protozoal constituents from Cuphea pinetorum, a plant used in Mayan traditional medicine to treat diarrhoea. Phytotherapy Research 19, 7250727.CrossRefGoogle Scholar
Calzada, F, Velazquez, C, Ledillo Rivera, R and Esquivel, B (2003) Antiprotozoal activity of the constituents of Teloxys gravelens. Phytotherapy Research 17, 731–732.CrossRefGoogle Scholar
Calzada, F, Mulia, L, Tapia-Contreras, A, Bautista, E, Maldonado, E and Ortigo, A (2010) Evaluation of anti-protozoal activity of neo clerodane type diterpenes from Salvia polystachya against E. histolytica infection. Phytotherapy Research 24, 662–665.CrossRefGoogle Scholar
Campos-Rodriguez, R, Jarillo-Luna, A, Ventura-Jurez, J, Shibayama, M, Pacheco-Yépez, J, Serrano-Luna, J and Tsutsumi, V (2000) Interaction of antibodies with Entamoeba histolytica trophozoites from experimental amebic liver abscess: an immunocytochemical study. Parasitology Research 86, 603–607.CrossRefGoogle ScholarPubMed
Cimanga, RK, Kambu, K, Tona, L, Hermans, N, Apers, S, Totte, J, Pieters, L and Vlietenck, AJ (2006) Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents. Journal of Ethanopharmacology 107, 83–90.CrossRefGoogle ScholarPubMed
Cochrane Training (2018) Cochrane Handbook for Systematic Reviews of Interventions Update September 2018 - Version 6. https://training.cochrane.org/handbook (accessed 28 January 2019).Google Scholar
Costa, CA, Nunes, ÁC, Ferreira, AJ, Gomes, MA and Caliari, MV (2010) Entamoeba histolytica and E. dispar trophozoites in the liver of hamsters: in vivo binding of antibodies and complement. Parasites Vectors 3, 23.CrossRefGoogle Scholar
Diaz-Godinez, C, Ontiveros-Rodriguez, JC, Rios-Valencia, , Herbert-Pucheta, JE, Zepeda-Valleje, and Carrero, JC (2020) Antiamoebic activity of leaf extracts and Aporphine alkaloids obtained from Annona purpurea. Planta Medica 86, 425–433.CrossRefGoogle Scholar
Domenguez, JV, Marchat, LA, Camarillo, CL, Hernendez, GM, Espindola, ES, Calzada, F, Hernandez, AO, Monroy, VS and Moreno, ER (2013) Effect of sesquiterpine lactone incomptine A in the energy metabolism of E. histolytica. Experimental Parasitology 135, 503–510.CrossRefGoogle Scholar
Drinic, M, Raninger, A, Zraungi, A, Astelbauer, F, Leitsch, D, Obwaller, A, Walochnik, J and Duchene, M (2019) Activity of methylgerambullin from Glycosmis species (Rutaceae) against Entamoeba. International Journal for Parasitology: Drugs and Drug Resistance 10, 109–117.Google ScholarPubMed
Elizondo Luevano, JH, Castro Rios, R, Sanchez- Garcia, E, Hernandez Garcia, M, Vargas-Villarreal, J, Rodriquez- luis, O and Chavez-Montes, A (2018) In vitro study of antiamoebic Mexicana on trophozoites of E. histolytica HM1-IMSS. Canadian Journal of Infectious Diseases and Medical Microbiology 2018, 7453787.CrossRefGoogle Scholar
Fox, LM and Saravolatz, LD (2005) Nitazoxanide: a new thiazolide antiparasitic agent. Clinical Infectious Diseases 40, 1173–1180.CrossRefGoogle ScholarPubMed
Ghoshal, S, Prasad, BNK and Lakshmi, V (1996) Antiamoebic activity of Piper longum fruits against E. histolytica invitro and invivo. Journal of Ethanopharmacology 50, 167–170.CrossRefGoogle Scholar
GRADE Working Group (1490) Grading quality of evidence and strength of recommendations. British Medical Journal 328, 1–8.Google Scholar
Haque, R, Huston, CD, Hughes, M, Houpt, E and Petri, WA Jr (2003) Amebiasis. The New England Journal of Medicine 348, 1565–1573.CrossRefGoogle ScholarPubMed
Hayat, F, Azam, A and Shin, D (2016) Recent progress on the discovery of antiamoebic agents. Bioorganic and Medicinal Chemistry Letters 26, 5149–5159.CrossRefGoogle ScholarPubMed
Herrera-Martínez, M, Hernández-Ramírez, VI, Hernández-Carlos, B, Chávez-Munguía, B, Calderón-Oropeza, MA and Talamás-Rohana, P (2016) Antiamoebic activity of Adenophyllum aurantium (L.) Strother and its effect on the actin cytoskeleton of Entamoeba histolytica. Frontiers in Pharmacology 7, 169.CrossRefGoogle ScholarPubMed
Hounkong, K, Swangjaroen, N, Kongyen, W, Rukachaisirikul, V, Voravyathikunchai, SP and Pongpachit, S (2014) Anti-intestinal protozoan activities of 1-hydroxy 2-hydroxymethylanthraquinone from Coptosapelta flavencens. Asian Pacific Journal of Tropical Disease 4, 457–462.CrossRefGoogle Scholar
Jiménez-Arellanes, A, Luna-Herrera, J, Ruiz-Nicolás, R, Cornejo-Garrido, J, Tapia, A and Yépez-Mulia, L (2013) Antiprotozoal and antimycobacterial activities of Persea americana seeds. BMC Complementary and Alternative Medicine 13, 109. Published 2013 May 16.CrossRefGoogle ScholarPubMed
Leitsch, D, Kolarich, D, Wilson, IB, Altmann, F and Duchêne, M (2007) Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. PLoS Biology 5, e211.CrossRefGoogle ScholarPubMed
Li, E and Stanley, SL Jr (1996) Parasitic diseases of the liver and intestines. Gastroenterology Clinics 25, 471–492.CrossRefGoogle Scholar
Marie, C and Petri, WA Jr (2013) Amoebic dysentery. BMJ Clinical Evidence 2013, 0918.Google ScholarPubMed
Marshall, SJ, Russell, PF, Phillipson, DJ, Kirby, CG, Warhust, DC and Wright, CW (2000) Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone. Phytotherapy Research 14, 356–358.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
McGaw, LJ, Jager, AK and Staden, JV (2001) Antibacterial, anthelmintic and anti-amoebiasis activity in South African medicinal plants. Journal of Ethnopharmacology 72, 247–263.CrossRefGoogle Scholar
Moundipa, PF, Flore, KGM, Bilong, CF and Bruchhaus, I (2005) In vitro amoebicidal activities of some medicinal plants of Bamun region. African Journal of Traditional, Complementary and Alternative Medicines 2, 113–121.CrossRefGoogle Scholar
Njoya, EM, Weber, C, Hernandez-Cuevas, NA, Hon, CC, Janin, Y, Kamini, MF, Moundipa, PF and Guillén, N (2009) Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes. PLoS Neglected Tropical Diseases 8, e2607.CrossRefGoogle Scholar
Padayachee, T and Odhav, B (2000) Antiamoebic activity against plant compounds isolated from Virgilia oroboides and Chlorophora excelsa 2001. Journal of Ethnopharmacology 78, 59–66.CrossRefGoogle Scholar
Petri, WA Jr and Haque, R (2010) Entamoeba species, including amoebiasis. In Mandell, GL, Bennett, JE and Dolin, R (eds), Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier, pp. 3411–3425.CrossRefGoogle Scholar
Quinones-guterrez, Y, Yerde Star, MJ, Rivas-Morales, C, Oranday-Cardenas, A, Mercado- Hernandez, R, Chavez-Montes, A and B-Gonzales, MP (2013) In vitro study of anti-amoebic activity of methanol extract of fruits of Pimpinello anisum on trophozoites of E. histolytica HM1-IMSS. African Journal of Biotechnology 12, 2065–2068.Google Scholar
Roca-Mézquita, C, Graniel-Sabido, M, Moo-Puc, RE, Leon-Déniz, LV, Gamboa-León, R, Arjona-Ruiz, C, Tun-Garrido, J, Mirón-López, G and Mena- Rejón, GJ (2016) Antiprotozoal activity of extracts of Elaeodendron trichotomum (Celastraceae). Africa Journal of Traditional Complementary and Alternative Medicine 13, 162–165.CrossRefGoogle Scholar
Samie, A, Obi, CL and Meyer, JJM (2013) In vitro cytotoxicity and anti-microbial activities against clinical isolated of Campylobacter species and Entamoeba histolytica, a local medicinal plant from the venda region, in South Africa. Annals of Tropical Medicine and Parasitology 103, 159–170.CrossRefGoogle Scholar
Sehgal, D, Bhattacharya, A and Bhattacharya, S (1996) Pathogenesis of infection by Entamoeba histolytica. Journal of Biosciences 21, 423–432.CrossRefGoogle Scholar
Shirley, DT, Farr, L, Watanabe, K and Moonah, S (2018) A review of the global burden, new diagnostics, and current therapeutics for amebiasis. Open Forum Infectious Diseases 5, ofy161.CrossRefGoogle ScholarPubMed
Sohini, YR, Kailam, P and Bhatt, RM (1995) The antiamoebic effect of crude drug formulation of herbal extracts against E. histolytica invitro and invivo. Journal of Ethanopharmacology 45, 43–52.CrossRefGoogle Scholar
Stanley, SL (2003) Amoebiasis. Lancet (London, England) 361, 1025–1034.CrossRefGoogle ScholarPubMed
Tapia-Pérez, ME, Tapia-Contreras, A, Cedillo-Rivera, R, Osuna, L and Meckes, M (2003) Screening of Mexican medicinal plants from antiprotozoal activity-Part II. Pharmaceutical Biology 41, 180–183.CrossRefGoogle Scholar
Tessema, TS, Schwamb, B, Lochner, M, Forster, I, Jakobi, V and Petry, F (2009) Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12 p40 knock-out mice during primary and challenge Cryptosporidium parvum infection. Immunobiology 214, 454–466.CrossRefGoogle ScholarPubMed
The Medical Letter (2013) Drugs for parasitic infections, 3rd ed. https://secure.medicalletter.org/article-share?a=143a&p=tg&title=Drugs%20for%20Parasitic%20Infections&cannotaccesstitle=1 (accessed 1 September 2017).Google Scholar
Tricco, AC, Lillie, E, Zarin, W, O'Brien, KK, Colquhoun, H, Levac, D, Moher, D, Peters, MDJ, Horsley, T, Weeks, L, Hempel, S, Akl, EA, Chang, C, McGowan, J, Stewart, L, Hartling, L, Aldcroft, A, Wilson, MG, Garritty, C, Lewin, S, Godfrey, CM, Macdonald, MT, Langlois, EV, Soares-Weiser, K, Moriarty, J, Clifford, T, Tunçalp, Ö and Straus, SE (2018) PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Annals of Internal Medicine 169, 467–473.CrossRefGoogle ScholarPubMed
Wardana, F, Sari, DK, Adianti, M, Permanasari, AA, Tunce, WUL, Nozaki, T, Widyawaruyanti, A and Hafid, AF (2018) Amoebic activities of Indonesian medicinal plants on Balikpapan East Kalimantan. In proceeding of BROMO conference. (BROMO, 77–82.CrossRefGoogle Scholar
World Health Organization (1994) Diarrhoeal Disease Control Programme. The Management of Bloody Diarrhoea in Young Children [WHO/CDD/94.49]. Geneva: World Health Organization.Google Scholar
World Health Organization (2005) The Treatment of Diarrhoea: A Manual for Physicians and Other Senior Health Workers [WHO/FCH/CAH/05.1], 4th ed. Geneva: World Health Organization.Google Scholar