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Studies on the resistance of rats to the nematode Nippostrongylus muris (Yokogawa, 1920). III. Attempt to transfer immunity adoptively

Published online by Cambridge University Press:  06 April 2009

G. C. Hunter  and
L. C. Leigh
G. C. Hunter
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen
L. C. Leigh
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen
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Extract

Two attempts to transfer immunity against N. muris to rats using the lymph node and spleen cells from actively immunized donors were unsuccessful. Experiments showed that the rats were sufficiently inbred, that the transfer technique was satisfactory, and that the donors were adequately immunized. The rats' competence as donors for adoptive transfer was demonstrated with sheep red cells as antigen. The adoptive transfer of immunity against sheep red cells was successful in recipients whose donors had sheep red cells only and no N. muris. There was no detectable transfer of immunity against N. muris or sheep red cells to recipients whose donors had received both.

We are very grateful to Miss Kathleen O'Brien for technical assistance, to Professor P. B. Medawar, F.R.S., for his help and advice and to Dr E. J. Delorme for showing us Professor M. F. A. Woodruff's skin-grafting technique.

Type
Research Article
Information
Parasitology , Volume 51 , Issue 3-4 , November 1961 , pp. 357 - 366
Copyright
Copyright © Cambridge University Press 1961

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References

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