Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-05-15T07:25:24.132Z Has data issue: false hasContentIssue false
  • English
  • Français

Stable infection of primates with Trypanosoma cruzi I and II

Published online by Cambridge University Press:  12 July 2006

C. V. LISBOA ,
R. H. MANGIA ,
S. L. B. LUZ ,
A. KLUCZKOVSKI ,
L. F. FERREIRA ,
C. T. RIBEIRO ,
O. FERNANDES  and
A. M. JANSEN
C. V. LISBOA
Affiliation:
Department of Protozoology, Laboratory of Biology of Tripanosomatid, Institute Oswaldo Cruz – IOC/FIOCRUZ, Av. Brasil 4365, Zip Code 21040-900, Rio de Janeiro, Brazil
R. H. MANGIA
Affiliation:
Department of Tropical Medicine, Laboratory of Molecular Epidemiology and Infeccion Diseases, Institute Oswaldo Cruz – IOC/FIOCRUZ, Av. Brasil 4365, Zip Code 21040-900, Rio de Janeiro, Brazil
S. L. B. LUZ
Affiliation:
Center of Research Leônidas & Maria Deane, Laboratory of Biodiversity, FIOCRUZ/AMAZONIA, Rua Teresina 476, Zip Code 69057-070, Manaus, Brazil
A. KLUCZKOVSKI
Affiliation:
Agency of Amazon Forest – AAF, Rua Recife 3280, Zip Code 69056-071, Manaus, Brazil
L. F. FERREIRA
Affiliation:
Department of Cartographic Engineering, Laboratory of Cartography, Institute Military of Engineering – IME, Praça General Tiburcio 80/DE-6, CEP: 22290-270, Rio de Janeiro, Brazil
C. T. RIBEIRO
Affiliation:
Wild Animals Screening Center – CETAS, Road 465, Km 3,5, Zip Code 23890-000, Itaguaí, Rio de Janeiro, Brazil
O. FERNANDES
Affiliation:
Department of Tropical Medicine, Laboratory of Molecular Epidemiology and Infeccion Diseases, Institute Oswaldo Cruz – IOC/FIOCRUZ, Av. Brasil 4365, Zip Code 21040-900, Rio de Janeiro, Brazil
A. M. JANSEN
Affiliation:
Department of Protozoology, Laboratory of Biology of Tripanosomatid, Institute Oswaldo Cruz – IOC/FIOCRUZ, Av. Brasil 4365, Zip Code 21040-900, Rio de Janeiro, Brazil
Get access Rights & Permissions [Opens in a new window]

Abstract

In order to better comprehend the putative association between genotype Trypanosoma cruzi II and primates, an evaluation of the infection in free ranging primates and specimens born in captivity from different geographical areas, the Amazon and the Atlantic forest, was carried out. Seroprevalences of the T. cruzi infection among the primates was similar in both biomes (45·5% and 46%). The parasites were isolated from 8 and 4 different species of primates, respectively from the Amazon and Atlantic forest. Multi-locus enzyme electrophoresis (MLEE) typed the isolates from Amazon as zymodeme 1. Mini-exon gene analysis characterized all these isolates as T. cruzi I, the main genotype circulating in the region. In the Atlantic forest, primates infected with TCI and TCII, as well as a mixed infection (TCI and TCII), were detected. These findings prove that primates may maintain stable infections by both genotypes. Moreover, data show that T. cruzi can occur in a wide range of primate genera, independent of their social behaviour, niches or habitats. Considering the high seroprevalence and stability of T. cruzi infection among the primates, these animals play an important role in the maintenance of the parasite in nature.

Keywords

Trypanosoma cruzineotropical primatestransmission cycleAmazon rainforestAtlantic rainforestmini-exon gene analysis
Type
Research Article
Information
Parasitology , Volume 133 , Issue 5 , November 2006 , pp. 603 - 611
Copyright
2006 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Briones, M. R. S., Souto, R. P., Stolf, B. S. and Zingales, B. ( 1999). The evolution of two Trypanosoma cruzi subgroups inferred from rRNA genes can be correlated with the interchange of American mammalian faunas in the Cenozoic and has implications to pathoogenicity and host specificity. Molecular and Biochemical Parasitology 104, 219–232.CrossRefGoogle Scholar
Chagas, C. ( 1924). Infection naturalla dês singes du Para (Chrysothrix sciureus L.), para Trypanosoma cruzi. Comptes Rendus Hebdomadaires des Séances et Mémoires de la Société de Biologie et de ses Filiales Comptes 90, 873–876.Google Scholar
Coura, J. R., Junqueira, A. C. V., Fernandes, O., Valente, S. A. S. and Miles, M. A. ( 2002). Emerging Chagas disease in Amazonian Brazil. Trends in Parasitology 18, 171–176.CrossRefGoogle Scholar
Cunnigham, A. A. ( 1996). Disease risks of wildlife translocation. Conservation Biology 12, 1139–1141.Google Scholar
De Thoisy, B., Vogel, L., Reynes, J., Pouliquen, J., Carme, B., Kazanji, M., & Vié, J. ( 2001). Health evaluation of translocation free – ranging primates in French Guiana. American Journal of Primatology 54, 1–16.Google Scholar
Fernandes, O., Santos, S. S., Cupolillo, E., Mendonca, B., Derre, R., Junqueira, A. C., Santos, L. C., Sturm, N. R., Naiff, R. D., Barret, T. V., Campbell, D. A. and Coura, J. R. ( 2001). A mini-exon multiplex polymerase chain reaction to distinguish the major groups of Trypanosoma cruzi and T. rangeli in the Brazilian Amazon. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 97–99.CrossRefGoogle Scholar
Fernandes, O., Mangia, R. H., Lisboa, C. V., Pinho, A. P., Morel, C. M., Zingales, B., Campbell, D. and Jansen, A. M. ( 1998). The complexity of the sylvatic cycle of Trypanosoma cruzi in the Rio de Janeiro state (Brazil) revealed by the non-transcribed spacer of the min-exon gene. Parasitology 118, 161–166.Google Scholar
GEOSENTINEL ( 2005). The Global Surveillance Network of the ISTM and CDC Chagas Disease Outbreak-Brazil, Santa Catarina. http://www.istm.org/geosentinel/advisory.html accessed 23.05.2005.
Herrera, H. M., Norek, A., Freitas, T. P., Rademaker, V., Fernandes, O. and Jansen, A. M. ( 2005). Domestic and wild mammals infection by Trypanosoma evansi in a pristine area of the Brazilian Pantanal region. Parasitology Research 96, 121–126.CrossRefGoogle Scholar
Herrera, L., D'andrea, P. S., Xavier, S. C., Mangia, R. H., Fernandes, O. and Jansen, A. M. ( 2005). Trypanosoma cruzi infection in wild mammals of the National Park ‘Serra da Capivara’ and its surroundings (Piaui, Brazil), an area endemic for Chagas disease. Transactions of the Royal Society of Tropical Medicine and Hygiene 99, 379–388.CrossRefGoogle Scholar
Jansen, A. M., Santos De Pinho, A. P., Lisboa, C. V., Cupolillo, E., Mangia, R. H. and Fernandes, O. ( 1999). The sylvatic cycle of Trypanosoma cruzi: a still unsolved puzzle. Memórias do Instituto Oswaldo Cruz 94, 203–204.CrossRefGoogle Scholar
Lisboa, C. V., Mangia, R. H., De Lima, N. R., Martins, A, Dietz, J., Baker, A. J., Ramon-Miranda, C. R., Ferreira, L. F., Fernandes, O. and Jansen, A. M. ( 2004). Distinct patterns of Trypanosoma cruzi infection in Leontopithecus rosalia in distinct Atlantic coastal rainforest fragments in Rio de Janeiro – Brazil. Parasitology 129, 703–711.CrossRefGoogle Scholar
Mangia, R. H., Piscinatti, A., Lisboa, C. V., Viegas, C., Jansen, A. M. and Fernandes, O. ( 2001). Experimental infection of New World primates with Trypanosoma cruzi I, II and both genotypes. XXVIII Annual Meeting on Basic Research in Chagas Disease, pp. 164–165.
Momen, H. and Salles, C. A. ( 1985). Enzyme markers for Vibrio Cholerae: identification of classical, El Tor and environmental strains. Transactions of the Royal Society of Tropical Medicine and Hygiene 79, 773–776.CrossRefGoogle Scholar
Nery-Guimarães, F., Da Silva, N. N., Clausell, D. T., De Mello, A. L., Rapone, T., Snell, T., Rodrigues, N. ( 1968). Um surto epidêmico de doença da Chagas de provável transmissão digestiva, ocorrido em Teutônia (Estrela – Rio Grande do Sul). O Hospital 73, 73–110.Google Scholar
Pavlovsky, E. N. ( 1966). Natural Nidality of Transmissible Diseases. University of Iilinois Press, Urbana and London.CrossRef
Pinho, A. P., Cuervo, P., Gripp, E., Costa, B., Herrera, H., D'Ándrea, P., Pádua, T., Rademaker, V., Fernandes, O., Cupolillo, E. and Jansen, A. M. ( 2003). Isoenzymatic characterization and genetic diversity of Trypanosoma cruzi isolates of wild animals from Pantanal, Brazil. Revista do Instituto de Medicina Tropical de São Paulo 45, 12.Google Scholar
Pinho, A. P., Cupolillo, E., Mangia, R. H., Fernandes, O. and Jansen, A. M. ( 2000). Trypanosoma cruzi in the sylvatic environment: distinct transmission cycles involving two sympatric marsupials. Transactions of the Royal Society of Tropical Medicine and Hygiene 94, 509–514.CrossRefGoogle Scholar
Pozio, E., Casulli, A., Bologov, V. V., Marucci, G. and La Rosa, G. ( 2001). Hunting practices increase the prevalence of Trichinella infection in wolves from European Russia. Journal of Parasitology 87, 1498–1501.CrossRefGoogle Scholar
Pung, O. J., Spratt, J., Clark, C. G., Norton, T. M. and Carter, J. ( 1998). Trypanosoma cruzi infection of free-ranging lion-tailed macaques (Macaca silenus) and ring-tailed lemurs (Lemur catta) on St. Catherine's Island, Georgia, USA. Journal of Zoo Wild Medicine 29, 25–30.Google Scholar
Sambrook, J., Fritsch, E. F. and Maniatis, T. ( 1989). Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press, New York.
Santos, C. D., Caldeira, J. C., Toldo, M. P. and Prado, J. C. ( 2005). Trypanosoma cruzi: effects of repetitive stress during the development of experimental infection. Experimental Parasitology 110, 96–101.CrossRefGoogle Scholar
Teixera, A. R., Monteiro, P. S., Rebelo, J. M., Arganaraz, E. R., Vieira, D., Lauria-Pires, L., Nascimento, R., Vexenat, C. A., Silva, A. R., Ault, S. K. and Costa, J. M. ( 2001). Emerging Chagas disease: trophic network and cycle of transmission of Trypanosoma cruzi from palm trees in the Amazon. Emerging Infectious Diseases 1, 100–112.CrossRefGoogle Scholar
Umezawa, E. S., Shikanai-Yasuda, M. A., Gruber, A., Pereira-Chioccola, V. L. and Zingales, B. ( 1996). Trypanosoma cruzi defined antigens in the serological evaluation of an outbreak of acute chagas disease in Brazil (Catolé do Rocha, Paraíba). Memórias do Instituto Oswaldo Cruz 91, 87–93.CrossRefGoogle Scholar
Valente, S. A., Valente, V. C. and Neto, H. F. ( 1999). Considerations on the epidemiology and transmission of Chagas Diseases in the Brazilian Amazon. Memórias do Instituto Oswaldo Cruz 94, 395–398.CrossRefGoogle Scholar
Yeo, M., Acosta, N., Llewellyn, M., Sanchez, H., Adamson, S., Miles, G. A., Lopez, E., Gonzalez, N., Patterson, J. S., Gaunt, M. W., De Arias, A. R. and Miles, M. A. ( 2005). Origins of Chagas disease: Didelphis species are natural hosts of Trypanosoma cruzi I and armadillos hosts of Trypanosoma cruzi II, including hybrids. International Journal for Parasitology 35, 225–233.CrossRefGoogle Scholar