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The presence of agglutinating antibody in the IgM immunoglobulin fraction of rabbit antiserum during experimental African trypanosomiasis*

Published online by Cambridge University Press:  06 April 2009

J. R. Seed ,
Renee L. Cornille ,
E. L. Risby  and
A. A. Gam
J. R. Seed
Affiliation:
Laboratory of Parasitology, Department of Biology, Tulane University, New Orleans, Louisiana
Renee L. Cornille
Affiliation:
Laboratory of Parasitology, Department of Biology, Tulane University, New Orleans, Louisiana
E. L. Risby
Affiliation:
Laboratory of Parasitology, Department of Biology, Tulane University, New Orleans, Louisiana
A. A. Gam
Affiliation:
Laboratory of Parasitology, Department of Biology, Tulane University, New Orleans, Louisiana
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Extract

The IgM levels in rabbits infected with Trypanosoma gambiense are raised. Agglutinating antibody has been found in the IgM immunoglobulin fraction of sera obtained from these infected rabbits. Agglutinating antibody was first found in the IgM fraction and later in the infection appeared in both the IgM and IgG fractions. Precipitating antibody to blood trypanosome antigens was found solely in the IgG fraction.

On the basis of the data presented here a working hypothesis is developed to explain the raised IgM immunoglobulin levels found in the sera of rabbits and humans infected with T. gambiense.

Type
Research Article
Information
Parasitology , Volume 59 , Issue 2 , May 1969 , pp. 283 - 292
Copyright
Copyright © Cambridge University Press 1969

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References

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