Hostname: page-component-848d4c4894-cjp7w Total loading time: 0 Render date: 2024-06-23T01:47:28.487Z Has data issue: false hasContentIssue false
  • English
  • Français

Pregnancy-induced recrudescences strengthen malarial immunity in mice infected with Plasmodium berghei

Published online by Cambridge University Press:  06 April 2009

A. A. J. C. Van Zon ,
W. M. C. Eling  and
C. C. Hermsen
A. A. J. C. Van Zon
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
W. M. C. Eling
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
C. C. Hermsen
Affiliation:
Department of Cytology and Histology, University of Nijmegen, Geert Grooteplein N 21, 6500 HB Nijmegen, The Netherlands
Get access Rights & Permissions [Opens in a new window]

Extract

A considerable proportion of mice lose acquired immunity to Plasmodium berghei during the first pregnancy. Immune parous mice, however, have a better immune status than virgin mice, the risk of loss of immunity during a subsequent pregnancy is greatly reduced, the capacity to clear parasites is enhanced, and the maintenance of immunity is less dependent on certain splenic functions. The establishment of improved immunity is dependent on the presence of proliferating parasites during the second half of pregnancy when immunosup pression results in recrudescence. Immune reactivity is also improved after a (chemothera peutically controlled) recrudescent infection provoked by immunosuppressive treatment of immune mice with corticoids or anti-T cell serum. This mimics the situation encountered during pregnancy. Hence, improved immunity after pregnancy is a consequence of a reconfrontation of a suppressed and/or convalescent immune system with proliferating parasites.

Type
Research Article
Information
Parasitology , Volume 91 , Issue 1 , August 1985 , pp. 9 - 17
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Beer, A. E. & Billinoham, R. E. (1972). Immunobiology of mammalian reproduction. Advances in Immunology 14, 1–84.Google Scholar
Brabin, B. J. (1983). An analysis of malaria in pregnancy in Africa. Bulletin of the World Health Organization 61, 1005–16.Google ScholarPubMed
Bray, R. S. & Anderson, M. J. (1979). Falciparum malaria and pregnancy. Transactions of the Royal Society of Tropical Medicine and Hygiene 73, 427–31.CrossRefGoogle ScholarPubMed
Campbell, C. C., Martinez, J. M. & Collins, W. E. (1980). Seroepidemiological studies of malaria in pregnant women and newborns from coastal El Salvador. Transactions of the Royal Society of Tropical Medicine and Hygiene 29, 15 1–7.Google ScholarPubMed
Cannon, D. S. H. (1958). Malaria and prematurity in the western region of Nigeria. British Medical Journal 2, 877–8.CrossRefGoogle ScholarPubMed
Elino, W. M. C. (1978). Malaria immunity and premunition in a Plasmodium berghei mouse model. Israel Journal of Medical Sciences 14, 542–53.Google Scholar
Eling, W. M. C. (1979). Plasmodium berghei: effect of antithymocyte serum on induction of immunity in the mouse. Experimental Parasitology 47, 403–9.CrossRefGoogle ScholarPubMed
Eling, W. M. C. (1980 a). Plasmodium berghei: premunition, sterile immunity and loss of immunity in mice. Experimental Parasitology 49, 89–96.CrossRefGoogle ScholarPubMed
Eling, W. M. C. (1980 b). Strain specificities in murine malaria with emphasis on immunological responsiveness. In Animal Quality and Models in Biochemical Research (ed. Spiegel, A., Erichsen, S. and Solleveld, H. A.), pp. 91–5. Stuttgart and New York: Gustav Fischer.Google Scholar
Eling, W. & Jerusalem, C. (1977). Active immunization against the malaria parasite Plasmodium berghei in mice: sulfathiazole treatment of a P. berghei infection and development of immunity. Tropenmedizin und Parasitologie 28, 158–74.Google Scholar
Eling, W., van Zon, A. & Jerusalem, C. (1977). The course of a Plasmodium berghei infection in six different mouse strains. Zeitechrift für Parasitenkunde 54, 29–45.CrossRefGoogle ScholarPubMed
Fabris, N., Piantanelli, L. & Muzzioli, M. (1977). Differential effect of pregnancy or gestagens on humoral and cell-mediated immunity. Clinical and Experimental Immunology 28, 306–14.Google ScholarPubMed
Gilles, H. M., Lawson, J. B., Sibelas, M., Voller, A. & Allan, N. (1969). Malaria, anaemia and pregnancy. Annals of Tropical Medicine and Parasitology 63, 245–63.CrossRefGoogle ScholarPubMed
Jayawardena, A. N. (1981). Immune responses in malaria. In Parasitic Diseases, vol. 1, The Immunology (ed. Mansfield, J.), pp. 85–136. New York: Marcel Dekker.Google Scholar
Lore, Y. W. (1978). Immunology and Immunopathology of the Human Foetal–Maternal Interaction. Amsterdam: Elsevier.Google Scholar
McGregor, I. A., Wilson, M. E. & Billewicz, W. Z. (1983). Malaria infection of the placenta in The Gambia, West Africa; its incidence and relationship to stillbirth, birthweight and placental weight. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 232–44.CrossRefGoogle ScholarPubMed
Menon, R. (1972). Pregnancy and malaria. Medical Journal of Malaysia 27, 115–19.Google ScholarPubMed
Playfair, J. H. L. (1982). Immunity to malaria. British Medical Bulletin 38, 153–9.CrossRefGoogle ScholarPubMed
Reinhardt, M. C., Ameroise-Thomas, P., Cavallo-Serra, R., Meylan, C. & Gautier, R. (1978). Malaria at delivery in Abidjan. Helvetica Paedialrica Ada 33, Suppl. 41, 65–84.Google Scholar
Taufa, T. (1978). Malaria and pregnancy. Papua New Guinea Medical Journal 21, 197–206.Google ScholarPubMed
Van Zon, A. A. J. C & Eling, W. M. C. (1980 a). Depressed malarial immunity in pregnant mice. Infection and Immunity 28, 630–2.CrossRefGoogle ScholarPubMed