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Malarial parasites and antioxidant nutrients

Published online by Cambridge University Press:  06 April 2009

O. A. Levander  and
A. L. Ager Jr
O. A. Levander
Affiliation:
Vitamin and Mineral Nutrition Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, ARS, Beltsville, Maryland 20705-2350, USA
A. L. Ager Jr
Affiliation:
Center for Tropical Parasitic Diseases, Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33177, USA
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Summary

Susceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is the fact that nutritional manipulation of host oxidative stress status by dietary means can have a profound effect on the growth of the parasite. In particular, rapid induction of vitamin E deficiency in mice by feeding highly unsaturated fatty acids (fish oil) strongly suppresses plasmodial growth. Likewise, the status of other antioxidant nutrients (e.g., riboflavin or vitamin C) may also influence the course of malarial infection under certain conditions. A combined nutritional pharmacology approach may offer some promise in controlling malaria.

Keywords

malariaoxidative stresslipid peroxidationantioxidantpro-oxidantPlasmodiumvitamin Efish oilseleniumvitamin Criboflavintocopherolascorbic acid
Type
Research Article
Information
Parasitology , Volume 107 , supplement S1: Human nutrition and parasitic infection , January 1993 , pp. S95 - S106
Copyright
Copyright © Cambridge University Press 1993

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