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Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China

Published online by Cambridge University Press:  02 September 2010

WEI WANG ,
JIAN-RONG DAI ,
HONG-JUN LI ,
XUE-HUI SHEN  and
YOU-SHENG LIANG
WEI WANG
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
JIAN-RONG DAI
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
HONG-JUN LI
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
XUE-HUI SHEN
Affiliation:
Dantu District Center for Disease Control and Prevention, Dantu 212004, Zhenjiang City, Jiangsu Province, China
YOU-SHENG LIANG*
Affiliation:
Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China
*
*Corresponding author: Jiangsu Institute of Parasitic Diseases, Meiyuan, 117 Yangxiang, Wuxi 214064, Jiangsu Province, China. Tel: +86 510 8551 7721. Fax: +86 510 8551 0263. E-mail: wxliangyousheng@yahoo.cn
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Summary

Praziquantel is widely used for the treatment of human schistosomiasis. However, in recent years, there has been increasing concern about the resistance of Schistosoma species to praziquantel. The study described here was designed to evaluate the current susceptibility to praziquantel in S. japonicum in China. During the non-transmission period of schistosomiasis, a random sample of 4760 subjects from the main endemic foci of China were examined using parasitological stool examination. In total, 584 subjects were identified as being infected with S. japonicum, with a prevalence rate of 12 27%. Among them, 565 stool-egg-positive subjects were treated with praziquantel in a single oral dose of 40 mg/kg. Six weeks post-treatment, among the 505 villagers re-examined, 480 (95 05%) had no detectable S. japonicum eggs. Twenty-one subjects still excreting eggs after the first treatment were treated with praziquantel for the second time. All stool samples, including those from those participants with second treatment were re-examined 6 weeks after the second treatment, and no stool-egg-positives were found. The results indicate that the current efficacy of praziquantel against S. japonicum is still high and has not changed after more than 2 decades of repeated, expanded chemotherapy in the main endemic areas of China. It is suggested that no evidence of tolerance or resistance to praziquantel in S. japonicum was detected in China.

Keywords

Schistosoma japonicumpraziquantelsusceptibilitydrug resistancechemotherapyChina
Type
Research Article
Information
Parasitology , Volume 137 , Issue 13 , November 2010 , pp. 1905 - 1912
Copyright
Copyright © Cambridge University Press 2010

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References

REFERENCES

Alonso, D., Muñoz, J., Gascón, J., Valls, M. E. and Corachan, M. (2006). Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection. American Journal of Tropical Medicine and Hygiene 74, 342–344.CrossRefGoogle ScholarPubMed
Anon. (1986). Guideline for Application of Praziquantel. Publishing House of Chinese Journal of Schistosomiasis Control, Wuxi, China.Google Scholar
Bennett, J. L., Day, T., Liang, F. T., Ismail, M. and Farghaly, A. (1997). The development of resistance to anthelmintics: a perspective with an emphasis on the antischistosomal drug praziquantel. Experimental Parasitology 87, 260–267.CrossRefGoogle ScholarPubMed
Chen, M. G. (2005). Use of praziquantel for clinical treatment and morbidity control of schistosomiasis japonica in China: a review of 30 years’ experience. Acta Tropica 96, 168–176.Google Scholar
Chen, X. Y., Wang, L. Y., Cai, J. M., Zhou, X. N., Zheng, J., Guo, J. G., Wu, X. H., Engels, D. and Chen, M. G. (2005). Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992–2001). Bulletin of the World Health Organization 83, 43–48.Google Scholar
Danso-Appiah, A. and De Vlas, S. J. (2002). Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal. Trends in Parasitology 18, 125–129.CrossRefGoogle ScholarPubMed
Fallon, P. G. and Doenhoff, M. J. (1994). Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. American Journal of Tropical Medicine and Hygiene 51, 83–88.CrossRefGoogle ScholarPubMed
Fallon, P. G., Sturrock, R. F., Niang, A. C. and Doenhoff, M. J. (1995). Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 53, 61–62.CrossRefGoogle Scholar
Fu, S., Xiao, S. H. and Catto, B. A. (1988). Clinical use of praziquantel in China. Parasitology Today 4, 312–315.Google ScholarPubMed
Gönnert, R. and Andrews, P. (1977). Praziquantel, a new broad-spectrum antischistosomal agent. Zeitschrift für Parasitenkunde 52, 129–150.CrossRefGoogle Scholar
Gryseels, B., Stelma, F. F., Talla, I., van Dam, G. J., Polman, K., Sow, S., Diaw, M., Sturrock, R. F., Doehring-Schwerdtfeger, E., Kardorff, R., Decam, C., Niang, M. and Deelder, A. M. (1994). Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal. Tropical and Geographical Medicine 46, 209–219.Google Scholar
Guisse, F., Polman, K., Stelma, F. F., Mbaye, A., Talla, I., Niang, M., Deelder, A. M., Ndir, O. and Gryseels, B. (1997). Therapeutic evaluation of two different dose regimens of praziquantel in a recent Schistosoma mansoni focus in Northern Senegal. American Journal of Tropical Medicine and Hygiene 56, 511–514.CrossRefGoogle Scholar
Hao, Y., Wu, X. H., Zheng, H., Wang, L. Y., Guo, J. G., Xia, G., Chen, Z. and Zhou, X. N. (2008). Schistosomiasis situation in People's Republic of China in 2007. Chinese Journal of Schistosomiasis Control 20, 401–404.Google Scholar
He, Y. X., Hu, Y. Q. and Yu, Q. F. (1992). Sensitivity of different isolates of Schistosoma japonicum from China to praziquantel. Southeast Asian Journal of Tropical Medicine and Public Health 23, 261–263.Google ScholarPubMed
Ismail, M., Attia, M., Metweally, A. A., Farghaly, A. M., Bruce, J., Bennett, J., el-Badawy, A. A. and Hussein, M. H. (1994 a). Assessment of praziquantel therapy in treatment of Schistosoma mansoni infection. Journal of the Egyptian Society of Parasitology 24, 231–238.Google ScholarPubMed
Ismail, M., Botros, S., Metwally, A., William, S., Farghally, A., Tao, L. F., Day, T. A. and Bennett, J. L. (1999). Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. American Journal of Tropical Medicine and Hygiene 60, 932–935.CrossRefGoogle ScholarPubMed
Ismail, M., Metwally, A., Farghaly, A., Bruce, J., Tao, L. F. and Bennett, J. L. (1996). Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. American Journal of Tropical Medicine and Hygiene 55, 214–218.CrossRefGoogle ScholarPubMed
Ismail, M. M., Taha, S. A., Farghaly, A. M. and el-Azony, A. S. (1994 b). Laboratory induced resistance to praziquantel in experimental schistosomiasis. Journal of the Egyptian Society of Parasitology 24, 685–695.Google ScholarPubMed
Jordon, P., Webbe, G. and Sturrock, R. F. (1993). Human Schistosomiasis. CAB International, Wallingford, UK.Google Scholar
Katz, N., Chaves, A. and Pellegrino, J. (1972). A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Revista do Instituto de Medicina Tropical de São Paulo 14, 397–400.Google ScholarPubMed
Kumar, V. and Gryseels, B. (1994). Use of praziquantel against schistosomiasis: a review of current status. The International Journal of Antimicrobial Agents 4, 313–320.CrossRefGoogle ScholarPubMed
Li, S. Z., Luz, A., Wang, X. H., Xu, L. L., Wang, Q., Qian, Y. J., Wu, X. H., Guo, J. G., Xia, G., Wang, L. Y. and Zhou, X. N. (2009). Schistosomiasis in China: acute infections during 2005–2008. Chinese Medical Journal 122, 1009–1014.Google Scholar
Liang, Y. S., Coles, G. C. and Doenhoff, M. J. (2000). Detection of praziquantel resistance in schistosomes. Tropical Medicine and International Health 5, 72.CrossRefGoogle ScholarPubMed
Liang, Y. S., Dai, J. R., Ning, A., Yu, D. B., Xu, X. J., Zhu, Y. C. and Coles, G. C. (2001). Susceptibility of Schistosoma japonicum to praziquantel in China. Tropical Medicine and International Health 6, 707–714.CrossRefGoogle ScholarPubMed
Lin, D. D., Liu, J. X., Liu, Y. M., Hu, F., Zhang, Y. Y., Xu, J. M., Li, J. Y., Bergquist, R., Wu, G. L. and Wu, H. W. (2008). Routine Kato-Katz technique underestimates the prevalence of Schistosoma japonicum: A case study in an endemic area of the Peoples' Republic of China. Parasitology International 57, 281–286.CrossRefGoogle Scholar
McManus, D. P., Li, Y., Gray, D. J. and Ross, A. G. (2009). Conquering ‘snail fever’: schistosomiasis and its control in China. Expert Review of Anti-infective Therapy 7, 473–485.CrossRefGoogle ScholarPubMed
Melman, S. D., Steinauer, M. L., Cunningham, C., Kubatko, L. S., Mwangi, I. N., Wynn, N. B., Mutuku, M. W., Karanja, D. M., Colley, D. G., Black, C. L., Secor, W. E., Mkoji, G. M. and Loker, E. S. (2009). Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni. PLoS Neglected Tropical Diseases 3, e504.CrossRefGoogle ScholarPubMed
Mitchell, G. F., Davern, K. M., Wood, S. M., Wright, M. D., Argyropoulos, V. P., McLeod, K. S., Tiu, W. U. and Garcia, E. G. (1990). Attempts to induce resistance in mice to Schistosoma japonicum and Schistosoma mansoni by exposure to crude schistosome antigens plus cloned glutathione-S-transferases. Immunology and Cell Biology 68, 377–385.CrossRefGoogle ScholarPubMed
MOH. (1993). Guidelines for World Bank Loan Project for Schistosomiasis Control in China. Shanghai Publishing House of Science and Technology, Shanghai, China.Google Scholar
Prociv, P. (1997). A case of refractory schistosomiasis. The Medical Journal of Australia 166, 568.CrossRefGoogle ScholarPubMed
Sabah, A. A., Fletcher, C., Webbe, G. and Doenhoff, M. J. (1986). Schistosoma mansoni: chemotherapy of infections of different ages. Experimental Parasitology 61, 294–303.CrossRefGoogle ScholarPubMed
Seubert, J., Pohlke, R. and Loebich, F. (1977). Synthesis and properties of praziquantel, a novel broad spectrum anthelmintic with excellent activity against schistosomes and cestodes. Experientia 33, 1036–1037.CrossRefGoogle ScholarPubMed
Silva, I. M., Thiengo, R., Conceição, M. J., Rey, L., Lenzi, H. L., Pereira Filho, E. and Ribeiro, P. C. (2005). Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa. Memórias do Instituto Oswaldo Cruz 100, 445–449.CrossRefGoogle ScholarPubMed
Sobhon, P. and Upatham, E. S. (1990). Snail Hosts, Life-Cycle, and Tegumental Structure of Oriental Schistosomes. Lincoln Promotion, Tokyo, Japan.Google Scholar
Stelma, F. F., Sall, S., Daff, B., Sow, S., Niang, M. and Gryseels, B. (1997). Oxamniquine cures Schistosoma mansoni infection in a focus in which cure rates with praziquantel are unusually low. The Journal of Infectious Diseases 176, 304–307.CrossRefGoogle Scholar
Stelma, F. F., Talla, I., Sow, S., Kongs, A., Niang, M., Polman, K., Deelder, A. M. and Gryseels, B. (1995). Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni. American Journal of Tropical Medicine and Hygiene 53, 167–170.CrossRefGoogle Scholar
Tchuem Tchuenté, L. A., Southgate, V. R., Mbaye, A., Engels, D. and Gryseels, B. (2001). The efficacy of praziquantel against Schistosoma mansoni infection in Ndombo, northern Senegal. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 65–66.CrossRefGoogle ScholarPubMed
Wang, L. D. (2005). Management of human and animal feces is a key element for effective control of epidemic and of endemic schistosomiasis in China. Chinese Journal of Epidemiology 26, 929–930.Google ScholarPubMed
Wang, L. D., Chen, H. G., Guo, J. G., Zeng, X. J., Hong, X. L., Xiong, J. J., Wu, X. H., Wang, X. H., Wang, L. Y., Xia, G., Hao, Y., Chin, D. P. and Zhou, X. N. (2009). A strategy to control transmission of Schistosoma japonicum in China. The New England Journal of Medicine 360, 121–128.CrossRefGoogle ScholarPubMed
Wang, L. D., Utzinger, J. and Zhou, X. N. (2008). Schistosomiasis control: experiences and lessons from China. The Lancet 372, 1793–1795.CrossRefGoogle ScholarPubMed
Wang, T. P., Vang Johansen, M., Zhang, S. Q., Wang, F. F., Wu, W. D., Zhang, G. H., Pan, X. P., Ju, Y. and Ørnbjerg, N. (2005). Transmission of Schistosoma japonicum by humans and domestic animals in the Yangtze River valley, Anhui province, China. Acta Tropica 96, 198–204.CrossRefGoogle ScholarPubMed
World Health Organization (1993). The Control of Schistosomiasis: Second Report of WHO Expert Committee. WHO Technical Report Series No. 830. Geneva, Switzerland.Google Scholar
Wu, Z., Zhang, S. J., Pan, B., Hu, L., Wei, R., Gao, Z., Li, J. and Uwe, B. (1993). Reinfection with Schistosoma japonicum after treatment with praziquantel in Poyang Lake region, China. Southeast Asian Journal of Tropical Medicine and Public Health 25, 163–169.Google Scholar
Xiao, S. H. (2005). Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins. Acta Tropica 96, 153–167.Google Scholar
Xiao, S. H., Catto, B. A. and Webster, L. T. Jr. (1995). Effects of praziquantel on different developmental stages of Schistosoma mansoni in vitro and in vivo. The Journal of Infectious Diseases 151, 1130–1137.CrossRefGoogle Scholar
Xiao, S. H., Yue, W. J., Yang, Y. Q. and You, J. Q. (1987). Susceptibility of Schistosoma japonicum to different developmental stages to praziquantel. Chinese Medical Journal 100, 759–768.Google ScholarPubMed
Yang, J., Zhao, Z., Li, Y., Krewski, D. and Wen, S. W. (2009). A multi-level analysis of risk factors for Schistosoma japonicum infection in China. International Journal of Infectious Diseases 13, e407–e412.CrossRefGoogle ScholarPubMed
You, J. Q., Xiao, S. H. and Yue, W. J. (1986). Effect of praziquantel in vitro on different developmental stages of Schistosoma japonicum. Acta Pharmacologica Sinica 7, 82–84.Google ScholarPubMed
Yu, D. B., Li, Y., Sleigh, A. C., Yu, X. L., Li, Y. S., Wei, W. Y., Liang, Y. S. and McManus, D. P. (2001). Efficacy of praziquantel against Schistosoma japonicum: field evaluation in an area with repeated chemotherapy compared with a newly identified endemic focus in Hunan, China. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 537–541.CrossRefGoogle Scholar
Yu, Q., Wang, Q. Z., Lü, D. B., Wang, F. F., Wu, W. D., Wang, T. P. and Guo, J. G. (2009). Infectious status of infection sources in the epidemic regions of schistosomiasis japonica in China. Chinese Journal of Preventive Medicine 43, 309–313.Google ScholarPubMed
Yue, W. J., Yu, S. H. and Xu, X. J. (1990). Failure to induce resistance of Schistosoma japonicum to praziquantel. Southeast Asian Journal of Tropical Medicine and Public Health 21, 85–89.Google ScholarPubMed
Zhang, Y. Y., Luo, J. P., Liu, Y. M., Wang, Q. Z., Chen, J. H., Xu, M. X., Xu, J. M., Wu, J., Tu, X. M., Wu, G. L., Zhang, Z. S. and Wu, H. W. (2009). Evaluation of Kato-Katz examination method in three areas with low-level endemicity of schistosomiasis japonica in China: A Bayesian modeling approach. Acta Tropica 112, 16–22.CrossRefGoogle Scholar
Zhou, X. N., Guo, J. G., Wu, X. H., Jiang, Q. W., Zheng, J., Dang, H., Wang, X. H., Xu, J., Zhu, H. Q., Wu, G. L., Li, Y. S., Xu, X. J., Chen, H. G., Wang, T. P., Zhu, Y. C., Qiu, D. C., Dong, X. Q., Zhao, G. M., Zhang, S. J., Zhao, N. Q., Xia, G., Wang, L. Y., Zhang, S. Q., Lin, D. D., Chen, M. G. and Hao, Y. (2007). Epidemiology of schistosomiasis in the People's Republic of China, 2004. Emerging Infectious Diseases 13, 1470–1476.CrossRefGoogle ScholarPubMed
Zhou, X. N., Wang, T. P., Wang, L. Y., Guo, J. G., Yu, Q., Xu, J., Wang, R. B., Chen, Z. and Tia, T. W. (2004). The current status of schistosomiasis epidemics in China. Chinese Journal of Epidemiology 25, 555–558.Google ScholarPubMed
Zhou, Y. B., Zhao, G. M. and Jiang, Q. W. (2007). Effects of the praziquantel-based control of schistosomiasis japonica in China. Annals of Tropical Medicine and Parasitology 101, 695–703.CrossRefGoogle ScholarPubMed