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Immunization against cerebral pathology in Plasmodium berghei-infected mice

Published online by Cambridge University Press:  06 April 2009

J. H. A. J. Curfs ,
C. C. Hermsen ,
J. H. E. TH. Meuwissen  and
W. M. C. ELING
J. H. A. J. Curfs
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
C. C. Hermsen
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
J. H. E. TH. Meuwissen
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
W. M. C. ELING
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Extract

The development of cerebral lesions in Plasmodium berghei-infected mice was dependent on the Strain of mice and the size of the infectious inoculum. In particular, C57B1/6J mice develop cerebral lesions when infected with low numbers of parasitized erythrocytes. By increasing the number of parasites in the infectious inoculum, the percentage of animals that develop cerebral malaria is decreased. Varying degrees of protection against the development of cerebral malaria can be obtained by several methods of immunization. (1) Injection of mice with large numbers of disrupted parasitized erythrocytes 1 or 2 weeks before the challenge infection (protection up to 70%). (2) A 2-day immunizing infection given 9 or 14 days before the challenge infection (protection up to 85%). (3) Injection of mice with plasmodial exoantigen preparations 1 week before the challenge infection (variable protection-rate, up to 100%). In all mice protected against cerebral malaria, parasitaemia is not affected by the immunizing treatment, indicating that protective mechanisms against cerebral malaria and parasitaemia are independent.

Keywords

Plasmodium bergheicerebral malariaimmunization.
Type
Research Article
Information
Parasitology , Volume 105 , Issue 1 , August 1992 , pp. 7 - 14
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Bate, C. A. W., Taverne, J. & Playfair, J. H. L. (1989). Soluble malarial antigens are toxic and induce the production of tumour necrosis factor in vivo. Immunology 66, 600–5.Google ScholarPubMed
Clark, I. A. (1987). Cell-mediated immunity in protection and pathology of malaria. Parasitology Today 3, 300–5.Google Scholar
Curfs, J. H. A. J., Schetters, T. P. M., Hermsen, C. C., Jerusalem, C. R., Van Zon, A. A. J. C. & Eling, W. M. C. (1989). Immunological aspects of cerebral lesions in murine malaria. Clinical Experimental Immunology 75, 136–40.Google Scholar
Curfs, J. H. A. J., Van Der Meer, J. W. M., Sauerwein, R. W. & Eling, W. M. C. (1990). Low dosages of interleukin 1 protect mice against lethal cerebral malaria. Journal of Experimental Medicine 172, 1287–91.CrossRefGoogle ScholarPubMed
Eling, W. M. C. (1977). Separation of parasitised erythrocytes from Plasmodium berghei infected mouse blood. Transactions of the Royal Society of Tropical Medicine and Hygiene 71, 267–8.CrossRefGoogle Scholar
Eling, W. M. C. (1982). Immunopathological aspects in parasitic infections. In Fortschritte der Zoologie, Bund 27. Zbl. Bakt. Suppl. 12; Immune Reactions to Parasites (ed. Frank, W.), pp. 141–55. Stuttgart/New York: Gustav Fischer Verlag.Google Scholar
Grau, G. E., Fajardo, L. F., Piguet, P.-F., Allet, B., Lambert, P.-H. & Vassalli, P. (1987). Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237, 1210–12.Google Scholar
Grau, G. E., Piguet, P.-F., Engers, H. D., Louis, J. A., Vassalli, P. & Lambert, P.-H. (1986). L3T4+T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. Journal of Immunology 137, 2348–54.Google Scholar
Jerusalem, C. & Eling, W. M. C. (1969). Active immunisation against Plasmodium berghei malaria in mice, using different preparations of plasmodial antigen and different pathways of administration. Bulletin of the World Health Organization 40, 807–18.Google ScholarPubMed
Kamiyama, T., Tatsumi, M., Matsubara, J., Yamamoto, K., Rubio, Z., Cortes, C. & Fujii, H. (1987). Manifestation of cerebral malaria-like symptoms in the WM/Ms rat infected with Plasmodium berghei strain NK65. Journal of Parasitology 73, 1138–45.CrossRefGoogle ScholarPubMed
Lambert, P.-H. & Grau, G. E. (1989). Cerebral malaria. In New Strategies in Parasitology (ed. McAdam, K. P. W. J.), pp. 51–73. New York: Churchill Livingstone.Google Scholar
Rest, J. R. (1983). Pathogenesis of cerebral malaria in golden hamsters and inbred mice. Contributions to Microbiology and Immunology 7, 139–46.Google ScholarPubMed