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Hypothesis: impaired immunity as a factor which contributes to the spread of drug-resistance

Published online by Cambridge University Press:  06 April 2009

M. J. Doenhoff  and
A. J. S. Davies
M. J. Doenhoff
Affiliation:
1School of Biological Sciences, University College of North Wales, Bangor, Gwynedd LL57 2UW, UK
A. J. S. Davies
Affiliation:
281 Queens Road, Wimbledon, London SW19 8NR, UK
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Summary

Evidence has accrued to indicate that host defence mechanisms enhance the efficacy of many of the drugs used to treat infectious diseases. Because of this, and also because of the likelihood of increased pathogen loads in immunoincompetent hosts, some infections are less likely to be completely cured by normal regimens of chemotherapy in individuals with drastically impaired immune responsiveness. In such circumstances natural selection could result in the accelerated emergence of drug-resistant pathogens.

Keywords

drug resistanceimmunoincompetencechemotherapy
Type
Research Article
Information
Parasitology , Volume 105 , Issue S1: Chemotherapy and the immune system , January 1992 , pp. S103 - S105
Copyright
Copyright © Cambridge University Press 1992

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