Hostname: page-component-77c89778f8-m42fx Total loading time: 0 Render date: 2024-07-17T12:39:59.287Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of the host immune response on the longevity, fecundity and position in the intestine of Trichinella spiralis in mice

Published online by Cambridge University Press:  06 April 2009

M. W. Kennedy
M. W. Kennedy
Affiliation:
Department of Zoology, University of Glasgow, Glasgow G12 8QQ
Get access Rights & Permissions [Opens in a new window]

Summary

In female NIH strain mice, expulsion of a primary infection of the nematode Trichinella spiralis began on day 8 and was virtually complete by day 14 of infection. In secondary and tertiary infections, the number of larvae which established in the intestine was normal, but expulsion began on day 6 and was complete on day 10. In a primary infection the shedding of larvae by female worms began on day 5, reached its peak on days 6–7, began to decrease on day 8 and was minimal by day 10. In secondary and tertiary infections fecundity was depressed. The depression of fecundity occurred slightly in advance of worm loss. During the stable phase of infection, T. spiralis occurred in the anterior half of the small intestine. During expulsion, living worms were found increasingly in more posterior parts of the gut but their fecundity did not vary with position. After direct inoculation into the posterior ileum, adult and larval T. spiralis remained in the posterior half of the small intestine. In this position, larvae established in normal numbers, grew and reproduced normally. Therefore, any part of the small intestine was a suitable site for T. spiralis and expulsion is not merely due to a change in the position of the worms.

Type
Research Article
Information
Parasitology , Volume 80 , Issue 1 , February 1980 , pp. 49 - 60
Copyright
Copyright © Cambridge University Press 1980

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Alphey, T. J. W. (1970). Studies on the distribution and site location of Nippostrongylus brasiliensis within the small intestine of laboratory rats. Parasitology 61, 449–60.Google Scholar
Ballantyne, A. J., Sharpe, M. J. & Lee, D. L. (1978). Changes in the adenylate energy charge of Nippostrongylus brasiliensis and Nematodirus battus during the development of immunity to these nematodes in their hosts. Parasitology 76, 211–20.Google Scholar
Brambell, M. R. (1965). The distribution of a primary infestation of Nippostrongylus brasiliensis in the small intestine of laboratory rats. Parasitology 55, 313–24.Google Scholar
Bråten, T. & Hopkins, C. A. (1969). The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation. Parasitology 59, 891–905.Google Scholar
Campbell, W. C. (1967). Distribution of Trichinella spiralis in the small intestine of young mice. Journal of Parasitology 53, 395–7.Google Scholar
Castro, G. A. (1976). Spatial and temporal integration of host responses to intestinal stages of Trichinella spiralis: retro- and prospective views. In Biochemistry of Parasites and Host – Parasite Relationships (ed. Van den Bossche, H.) pp. 343 – 58. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
Connan, R. M. (1966). Experiments with Trichostrongylus colubriformis (Giles, 1892) in the guinea-pig. I. The effect of the host response on the distribution of the parasites in the gut. Parasitology 56, 521–30.Google Scholar
Denham, D. A. (1968). Immunity to Trichinella spiralis. III. The longevity of the intestinal phase of the infection in mice. Journal of Helminthology 42, 257–68.Google Scholar
Denham, D. A. & Martinez, A. R. (1970). Studies with methyridine and Trichinella spiralis. 2. The use of the drug to study the rate of larval production in mice. Journal of Helminthology 44, 357–63.Google Scholar
Despommier, D. D., Campbell, W. C. & Blair, L. S. (1977). The in vivo and in vitro analysis of immunity to Trichinella spiralis in mice and rats. Parasitology 74, 109–19.Google Scholar
Fatunmbi, O. O. (1978). Studies on some aspects of the development of Trichinella spiralis in mice. M.Sc. Dissertation, University of Glasgow.Google Scholar
Jacqueline, E., Vernes, A. & Biguet, J. (1978). Trichinella spiralis: facteurs immunitaires inhibiteurs de la production de larves. 1. Mise en evidence in vivo et in vitro chez la souris. Experimental Parasitology 45, 34–41.CrossRefGoogle Scholar
Jarrett, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. (1968). Quantitative studies on the kinetics of establishment and expulsion of intestinal nematode populations in susceptible and immune hosts. Nippostrongylus brasiliensis in the rat. Parasitology 58, 625–39.CrossRefGoogle ScholarPubMed
Kennedy, M. W., Wakelin, D. & Wilson, M. M. (1979). Transplantation of adult Trichinella spiralis: worm survival and immunological characteristics of the host-paraaite relationship. Parasitology 78, 121–30.Google Scholar
Larsh, J. E. Jr., (1963). Experimental trichiniasis. In Advances in Parasitology, vol. 1 (ed. Dawes, B.), pp. 213–86. London: Academic Press.Google Scholar
Larsh, J. E. Jr, Gilchrist, H. B. & Greenberg, B. G. (1952). A study of the distribution and longevity of adult Trichinella spiralis in immunized and non-immunized mice. Journal of the Elisha Mitchell Scientific Society 68, 1–11.Google Scholar
Larsh, J. E. Jr, & Hendricks, J. R. (1949). The probable explanation for the difference in the localization of adult Trichinella spiralis in young and old mice. Journal of Parasitology 35, 101–6.Google Scholar
Larsh, J. E. Jr. & Race, G. J. (1975). Allergic inflammation as a hypothesis for the expulsion of worms from tissues: a review. Experimental Parasitology 37, 251–66.CrossRefGoogle ScholarPubMed
Love, R. J., Ogilvie, B. M. & McLaren, D. J. (1976). The immune mechanism which expels the intestinal stage of Trichinella spiralis from rats. Immunology 30, 7–15.Google ScholarPubMed
Mccoy, O. R. (1931). Immunity of rats to reinfection with Trichinella spiralis. American Journal of Hygiene 14, 484–94.Google Scholar
Moqbel, R. & Denham, D. A. (1977). Strongyloides ratti: I. Parasitological observations on primary and secondary infections hi the small intestine of rats. Journal of Helminthology 51,301–8.CrossRefGoogle Scholar
Podhájecky, K. (1962). Localization of intestinal trichinellae in the small intestines of mice in their intestinal phase. Wiadomosci Parazytologiczne 8, 633–6.Google Scholar
Rappaport, I. & Wells, H. S. (1951). Studies in trichinosis. I. Immunity to reinfection following a single light infection. Journal of Infectious Diseases 88, 248–53.CrossRefGoogle ScholarPubMed
Sukhdeo, M. V. K. (1978). Site selection behaviour of Trichinella spiralis in Swiss mice. Parasitology 77, xliii.Google Scholar
Wakelin, D. & Lloyd, M. (1976 a). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72 173–82.Google Scholar
Wakelin, D. & Lloyd, M. (1976 b). Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors. Parasitology 72, 307–15.Google Scholar