Hostname: page-component-7479d7b7d-q6k6v Total loading time: 0 Render date: 2024-07-11T12:51:50.610Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of the tetrathyridia of Mesocestoides corti on the livers and peripheral blood of three different strains of mice

Published online by Cambridge University Press:  06 April 2009

S. L. Riley  and
J. Chernin
S. L. Riley
Affiliation:
School of Biological Sciences, University of Portsmouth, King Henry Building, Portsmouth PO1 2DY, UK
J. Chernin
Affiliation:
School of Biological Sciences, University of Portsmouth, King Henry Building, Portsmouth PO1 2DY, UK
Get access Rights & Permissions [Opens in a new window]

Summary

Three strains of male and female mice, CFLP, BALB/c and CBA/ca, were infected i.p. with the tetrathyridia of Mesocestoides corti and examined in groups of 5 at 0, 7, 14, 21, 28 and 42 days post-infection. At post-mortem the numbers of parasites both loose in the peritoneal cavity and in the liver tissue were counted, the livers weighed fresh and sections of liver stained to examine the inflammatory response, encapsulation of the tetrathyridia and for eosinophils, neutrophils, mast cells and plasma cells. BALB/c mice had significantly more parasites loose in the peritoneal cavity than CFLP and CBA/ca mice. Infected livers of all three strains were significantly heavier than control livers; the heaviest livers were those of the CFLP followed by the CBA/ca mice which also showed the greatest rate of weight increase. The tetrathyridia from the peritoneal cavities of the CBA/ca and CFLP mice were covered with a ‘mucilage-like’ substance. Tetrathyridia within the host capsules of the CBA/ca mice contained host cells. There was no strain difference with regard to numbers of tetrathyridia in the liver but male mice harboured significantly more parasites than females. Differences in the numbers of cell types within the liver were detected between the strains but no one strain showed any consistent pattern. There was an overall increase in total white blood counts as well as an increase in the number of eosinophils, monocytes, neutrophils and lymphocytes during the course of the infection.

Keywords

Mesocestoides cortitetrathyridiahistopathologyliverleucocytes
Type
Research Article
Information
Parasitology , Volume 109 , Issue 3 , September 1994 , pp. 291 - 297
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Chernin, J. & McLaren, D. J. (1983). The pathology induced in laboratory rats by the metacestodes of Taenia crassiceps and Mesocestoides corti (Cestoda). Parasitology 87, 279–87.CrossRefGoogle ScholarPubMed
Chernin, J., Miller, H. R. P., Newlands, G. F. J. & McLaren, D. J. (1988). Proteinase phenotypes and fixation properties of rat mast cells in parasitic lesions caused by Mesocestoides corti; selective and site specific recruitment of mast cell subsets. Parasite Immunology 10, 433–42.CrossRefGoogle ScholarPubMed
Cook, R. M., Ashworth, R. F. & Chernin, J. (1988). Cytotoxic activity of rat granulocytes against Mesocestoides corti. Parasite Immunology 10, 97–109.CrossRefGoogle ScholarPubMed
Culling, C. F. A. (1974). Handbook of Histopathological Techniques. 3rd Edn.Trowbridge and Esher: Butterworths.Google Scholar
Disbrey, B. D. & Rack, J. H. (1970). Histological Laboratory Methods. Edinburgh and London: E. & S. Livingston.Google Scholar
Dixon, W. J. (1988). BMDP Statistical Software Manual, Vols 1 and 2. Berkeley, California: University of California Press.Google Scholar
Kowalski, J. C. & Thorenson, R. E. (1972). Protective immunity against tetrathyridia of Mesocestoides corti by passive transfer of serum in mice. Journal of Parasitology 58, 244–6.CrossRefGoogle ScholarPubMed
Lammas, D. A., Mitchell, L. A. & Wakelin, D. (1990). Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoides corti. Parasitology 101, 291–9.CrossRefGoogle ScholarPubMed
Letonja, T. & Hammerberg, C. (1987). Taenia taeniaeformis: early inflammatory response around developing metacestodes in the liver of resistant and susceptible mice. I. Identification of leucocyte response with monoclonal antibodies. Journal of Parasitology 73, 962–70.CrossRefGoogle ScholarPubMed
Mitchell, G. F., Marchalonis, J. J., Smith, P. M., Nicholas, W. L. & Warner, N. L. (1977). Studies on the immune response to larval cestodes in mice: a simple mechanism of non-specific immunosuppression in Mesocestoides corti infected mice. Australian Journal of Experimental Biology and Medical Science 55, 615–22.CrossRefGoogle ScholarPubMed
Novak, M. (1972). Quantitative studies on the growth and multiplication of tetrathyridia of Mesocestoides corti Heoppli, 1925 (Cestoda: Cyclophyllidea) in rodents. Canadian Journal of Zoology 50, 1189–96.CrossRefGoogle Scholar
Pollaco, S., Nicholas, W. L., Mitchell, G. F. & Stewart, A. C. (1978). T-cell dependent collagenous encapsulating response in mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology 8, 457–62.CrossRefGoogle Scholar
Specht, D. & Widmer, E. A. (1972). Response of mouse liver to infection with tetrathyridia of Mesocestoides (Cestoda). Journal of Parasitology 58, 431–7.CrossRefGoogle ScholarPubMed
Stryer, L. (1981). Biochemistry, 2nd edn.New York & San Francisco: W. H. Freeman & Co.Google Scholar
Todd, K. S. Jr, Simon, J. & Dipietro, J. A. (1978). Pathological changes in mice infected with tetrathyridia of Mesocestoides corti. Laboratory Animals 12, 51–3.CrossRefGoogle ScholarPubMed
Voge, M. (1955). North American cestodes of the genus Mesocestoides. University of California Publications in Zoology 59, 125–56.Google Scholar
White, T. R., Thompson, R. C. A. & Penhale, W. J. (1982). A comparative study of inbred strains of mice to infection with Mesocestoides corti. International Journal for Parasitology 12, 29–33.CrossRefGoogle ScholarPubMed