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The effect of non-immune stresses on the development of Strongyloides ratti

Published online by Cambridge University Press:  04 May 2005

M. CROOK  and
M. E. VINEY
M. CROOK
Affiliation:
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
M. E. VINEY
Affiliation:
School of Biological Sciences, University of Bristol, Woodland Road, Bristol, BS8 1UG, UK
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Abstract

Strongyloides ratti is a parasitic nematode of rats. The host immune response against S. ratti affects the development of its free-living generation, favouring the development of free-living adult males and females at the expense of directly developing, infective 3rd-stage larvae. However, how the host immune response brings about these developmental effects is not clear. To begin to investigate this, we have determined the effect of non-immune stresses on the development of S. ratti. These non-immune stresses were subcurative doses of the anthelmintic drugs Ivermectin, Dithiazanine iodide and Thiabendazole, and infection of a non-natural host, the mouse. These treatments produced the opposite developmental outcome to that of the host immune response. Thus, in infections treated with subcurative doses of Ivermectin, Dithiazanine iodide and in infections of a non-natural host, the sex ratio of developing larvae became more female-biased and the proportion of female larvae that developed into free-living adult females decreased. This suggests that the mechanism by which the host immune response and these non-immune stresses affect S. ratti development differs.

Keywords

non-immune stressStrongyloides rattihost immune responsedevelopmentanthelmintic
Type
Research Article
Information
Parasitology , Volume 131 , Issue 3 , September 2005 , pp. 383 - 392
Copyright
© 2005 Cambridge University Press

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