Hostname: page-component-7479d7b7d-m9pkr Total loading time: 0 Render date: 2024-07-10T23:19:22.213Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of a low protein diet and a glucose and filter paper diet on the course of infection of Nippostrongylus brasiliensis

Published online by Cambridge University Press:  06 April 2009

Karen R. Clarke
Karen R. Clarke
Affiliation:
Department of Zoology, The University, Sheffield, England
Get access Rights & Permissions [Opens in a new window]

Extract

Rats were fed on two deficient diets and were infected with N. brasiliensis larvae. They were autopsied at times ranging from 18 hours to 17 days after infection. The effect of the diets on worm burden, sex ratio of the worms and size of larvae and of worms were noted. Significantly more larvae reached the lungs and intestine in rats fed on glucose and filter paper (G.F.P.) and low protein (L.P.) diets than in controls, the highest numbers coming from G.F.P. rats. Neither the migration rate nor the development of the worms was accelerated by the deficient diets. G.F.P. and control rats lost larvae soon after their arrival in the intestine. Adult worms were lost from rats on the deficient diets before they were lost in significant numbers by controls; this was not due to the initially larger worm burdens in the former rats. G.F.P. and control rats lost the bulk of their infections by 17 days; L.P. rats retained about 50% of the worm burden they had on the fourth day. The effect of the deficient diets on the migratory and adult phase of N. brasiliensis, and on susceptibility and resistance is discussed.

This work was done during the tenure of a Science Research Council Studentship. My thanks are due to Dr E. T. B. Francis for his helpful and critical supervision, and to Professor I. Chester Jones, in whose Department the work was carried out, for the facilities he provided.

Type
Research Article
Information
Parasitology , Volume 58 , Issue 2 , May 1968 , pp. 325 - 339
Copyright
Copyright © Cambridge University Press 1968

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Africa, C. M. (1931). Studies on the host relations of Nippostrongylus muris with special reference to age, resistance and acquired immunity. J. Parasit. 18, 1–13.CrossRefGoogle Scholar
Asirvadham, M. (1948). The bone marrow and its leukocytic response in protein deficiency. J. infect. Dis. 83, 87–100.Google Scholar
Barakat, M. R. (1948). Relationship between nutrition and parasitism in the experimental animal. Ph.D. Thesis, University of London.Google Scholar
Bezubik, B. (1960). Effect of cortisone on the susceptibility of hamsters and guinea pigs to the sheep and rabbit strain of Strongyloides papillosus. J. Parasit. 46, Suppl. 30–1. (Abstr.)Google Scholar
Briggs, N. T. (1959). The effect of cortisone on natural and acquired responses of the white rat to infection with Litomosoides carini. J. Parasit. 45, Suppl. 37. (Abstr.)Google Scholar
Cannon, P. R. (1942). Antibodies and the protein-reserves. J. Immunol. 44, 107–14.Google Scholar
Cavallero, C. & Sala, G. (1951). Cortisone and infection. Lancet 1, 175.Google Scholar
Chandler, A. C. (1932). Experiments on resistance of rats to superinfection with the nematode Nippostrongylus muris. Am. J. Hyg. 16, 750–82.Google Scholar
Clarke, K. R. (1967). Effect of deficient diets on corticosteroid synthesis by rat adrenals in vitro and its relationship to infections with Nippostrongylus brasiliensis (Travassos, 1914). (In the Press.)Google Scholar
Coker, C. M. (1956). Effects of cortisone on cellular inflammation in the musculature of mice given one infection of Trichinella spiralis. J. Parasit. 42, 479–84.Google Scholar
Cross, J. H. K. Jr (1960). The natural resistance of the white rat to Nematospiroides dubius and the effect of cortisone on this resistance. J. Parasit. 46, 175–85.Google Scholar
De Witt, W. B. & Weinstein, P. P. (1964). Elimination of intestinal helminths of mice by feeding purified diets. J. Parasit. 50, 429–34.Google Scholar
Donaldson, A. W. & Otto, G. F. (1946). Effects of protein-deficient diets on immunity to a nematode (Nippostrongylus muris) infection. Am. J. Hyg. 44, 384–400.Google Scholar
Haley, A. J. (1962). Biology of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914). II. Preparasitic stages and development in the laboratory rat. J. Parasit. 48, 13–23.CrossRefGoogle Scholar
Haley, A. J. (1966). Biology of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914). III. Characteristics of N. brasiliensis after 30–120 serial passages in the Syrian hamster. J. Parasit. 52, 98–109.CrossRefGoogle Scholar
Haley, A. J. & Parker, J. C. (1961). Size of adult Nippostrongylus brasiliensis from light and heavy infections in laboratory rats. J. Parasit. 47, 461.Google Scholar
Kaneko, T. (1939). Infection experiments of Nippostrongylus muris in the rat, in avitaminosis. Keio Igaku 19, 199–212.Google Scholar
Leutskaya, Z. K. (1964). The antibody level in vitamin A deficiency in chickens immunized with Ascaridia galli antigen. Dokl. Akad. Nauk SSSR. 159, 938–40.Google Scholar
Maldonado, J. F. & Asenjo, C. F. (1953). The role of pteroglutamic acid and vitamin B 12 on the development of Nippostrongylus muris in the rat. Expl Parasit. 2, 374–9.Google Scholar
Matsumori, M. (1941). Infection experiments of Nippostrongylus muris in the rat fed with diets destitute of and added with vitamin C. Keio Igaku 21, 1261–73.Google Scholar
Menkin, V. (1960). Biochemical mechanisms in inflammation. Br. Med. J. 1, 1521–8.CrossRefGoogle ScholarPubMed
Miles, A. A. & Wilson, G. S. (1946). Topley and Wilson's Principles of Bacteriology and Immunity, 3rd ed., vol. 2. London: Ed. Arnold Ltd.Google Scholar
Miles, J. A. R. (1951). Observations on the course of infection with certain natural bacterial pathogens of the rat in rats on protein-deficient diets. Br. J. exp Path. 32, 285–306.Google Scholar
Miyasaka, K. (1941). Infection experiment of Nippostrongylus muris in the rat fed with a preparation of the pupa of silkworm. Keio Igaku 21, 1365–75.Google Scholar
Nelson, W. A. (1962). Development in a sheep of resistance to the ked Melophagus ovinus (L.). II. Effects of adrenocorticotrophic hormone and cortisone. Expl Parasit. 12, 45–51.CrossRefGoogle Scholar
Oliver, L. (1962). Studies on natural resistance of Taenia taeniaeformis in mice. II. The effect of cortisone. J. Parasit. 48, 758–62.CrossRefGoogle Scholar
Parker, J. C. (1961). Effect of cortisone on the resistance of the guinea pig to infection with the rat nematode Nippostrongylus brasiliensis. Expl Parasit. 11, 380–90.CrossRefGoogle ScholarPubMed
Porter, D. A. (1935 a). A comparative study of Nippostrongylus muris in rats and mice. Am. J. Hyg. 22, 444–66.Google Scholar
Porter, D. A. (1935 b). Studies on the effect of milk diet on the resistance of rats to Nippostrongylus muris. Am. J. Hyg. 22, 467–74.Google Scholar
Read, C. P. (1958). Status of behavioral and physiological resistance. Rice Inst. Pamph. 45, 36–54.Google Scholar
Riley, E. G. (1943). The effect of various stages of vitamin A deficiency in the white rat on the resistance to Nippostrongylus muris. J. infect. Dis. 72, 133–41.Google Scholar
Rogers, W. P. & Lazarus, M. (1949). The uptake of radioactive phosphorus from host tissues and fluids by nematode parasites. Parasitology 39, 245–50.CrossRefGoogle ScholarPubMed
Spindler, R. L. A. (1933). Relation of vitamin A to the development of resistance in rats to superinfections with an intestinal nematode Nippostrongylus muris. J. Parasit. 20, 72.Google Scholar
Stoner, R. D. & Godwin, J. T. (1953). The effects of ACTH and cortisone upon susceptibility to Trichinosis in mice. Am. J. Path. 29, 943–50.Google ScholarPubMed
Sulzer, A. J. (1964). A serological study of rats and rabbits exposed to Nippostrongylus brasiliensis (Travassos, 1914). Diss. Abstr. 24, 3938–9.Google Scholar
Symons, L. E. A. (1960 a). Pathology of infestation of the rat with Nippostrongylus muris (Yokogawa). IV. The absorption of glucose and histidine. Aust. J. biol. Sci. 13, 180–7.CrossRefGoogle Scholar
Symons, L. E. A. (1960 b). Pathology of infestation of the rat with Nippostrongylus muris (Yokogawa). V. Protein digestion. Aust. J. biol. Sci. 13, 579–83.Google Scholar
Symons, L. E. A. & Fairbairn, D. (1962). Pathology, absorption, transport and activity of digestive enzymes in the rat jejunum parasitised by the nematode Nippostrongylus brasiliensis. Fedn Proc. Fedn Am. Socs. exp. Biol. 21, 913–18.Google Scholar
Symons, L. E. A. & Fairbairn, D. (1963). Biochemical pathology of the rat jejunum parasitised by the nematode Nippostrongylus brasiliensis. Expl Parasit. 13, 284–304.CrossRefGoogle Scholar
Taliaferro, W. H. & Sarles, M. P. (1939). The cellular reactions in the skin, lungs and intestine of normal, and immune rats after infection with Nippostrongylus muris. J. infect. Dis. 64, 157–92.CrossRefGoogle Scholar
Twohy, D. W. (1955). The role of the skin and the lungs in the development of Nippostrongylus muris. J. Parasit. 41, Suppl. 44. (Abstr.).Google Scholar
Twohy, D. W. (1956). The early migration and growth of Nippostrongylus muris in the rat. Am. J. Hyg. 63, 165–85.Google Scholar
Watt, J. Y. C. (1944). The influence of vitamin B 1 (Thiamine) and B 2 (Riboflavin) upon resistance of rats to infection with Nippostrongylus muris. Am. J. Hyg. 39, 145–51.Google Scholar
Watt, J. Y. C., Golden, W. R. C., Olason, F. & Mladinich, G. (1943). The relationship of vitamin A to resistance to Nippostrongylus muris. Science 97, 381–2.CrossRefGoogle ScholarPubMed
Weinstein, P. P. (1955). The effect of cortisone on the immune response of the white rat to Nippostrongylus muris. Am. J. trop. Med. Hyg. 4, 61–74.CrossRefGoogle ScholarPubMed
Weinstein, P. P. & Jones, M. F. (1956 a). The in vitro cultivation of Nippostrongylus muris to the adult stage. J. Parasit. 42, 215–36.CrossRefGoogle Scholar
Weinstein, P. P. & Jones, M. F. (1956 b). The effect of vitamins and protein hydrolysates on the growth in vitro of the free-living stages of Nippostrongylus muris under axenic conditions. J. Parasit. 42, 14.Google Scholar
Weinstein, P. P. & Jones, M. F. (1957). The development of a study on the axenic growth in vitro of Nippostrongylus muris to the adult stage. Am. J. trop. Med. Hyg. 6, 480–4.Google Scholar
Wells, P. D. (1962). Mast cell, eosinophil and histamine levels in Nippostrongylus brasiliensis infected rats. Expl Parasit. 12, 82–101.CrossRefGoogle ScholarPubMed
Wells, P. D. (1963). Mucin-secreting cells in rats infected with Nippostrongylus brasiliensis. Expl Parasit. 14, 15–22.Google Scholar
Wilson, P. A. & Dick, J. M. (1964). Culture and isolation of Nippostrongylus brasiliensis infective larvae for biochemical studies. J. Helminth. 38, 399–404.Google Scholar
Wissler, R. W., Woolridge, R. L. & Steffee, C. H. (1946). Influence of amino acid feeding upon antibody production in protein depleted rats. Proc. Soc. exp. Biol. Med. 62, 199–203.Google Scholar
Yokogawa, S. (1922). The development of Heligmosomum muris Yokogawa, a nematode from the intestine of the wild rat. Parasitology 14, 127–66.Google Scholar