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Detection of ecdysteroids in the human trematode, Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

G. Torpier ,
M. Hirn ,
P. Nirde ,
M. De Reggi  and
A. Capron
G. Torpier
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, INSERM U 167, Institut Pasteur, 15 rue Camille Guérin, 59019 Lille Cédex, France
M. Hirn
Affiliation:
Centre d'Immunologie de Marseille-Luminy, 70 route Léon Champ, 13288 Marseille Cédex 2, France
P. Nirde
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, INSERM U 167, Institut Pasteur, 15 rue Camille Guérin, 59019 Lille Cédex, France
M. De Reggi
Affiliation:
Centre d'Immunologie de Marseille-Luminy, 70 route Léon Champ, 13288 Marseille Cédex 2, France
A. Capron
Affiliation:
Centre d'Immunologie et de Biologie Parasitaire, INSERM U 167, Institut Pasteur, 15 rue Camille Guérin, 59019 Lille Cédex, France
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Summary

Freeze fracture study of Schistosoma mansoni membrane differentiation enabled us to describe the characteristic features of the tegumental membrane complex at various stages of development of this parasite. The observation of a membrane exuviation during the 10–20 day period of infection of the definitive host led us to search for possible hormonal control. The development of an appropriate radioimmunoassay has allowed the detection of significant production of ecdysteroids in a human platyhelminth. This hormonal material undergoes level variation during the development of post-cercarial stages of S. mansoni and its precise chemical characterization is presently being investigated.

Type
Research Article
Information
Parasitology , Volume 84 , Issue 1 , February 1982 , pp. 123 - 130
Copyright
Copyright © Cambridge University Press 1982

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