Hostname: page-component-76fb5796d-9pm4c Total loading time: 0 Render date: 2024-04-26T08:06:09.133Z Has data issue: false hasContentIssue false

The cloning of schistosome genes encoding antigenic and maturation-linked polypeptides

Published online by Cambridge University Press:  23 August 2011

M. Knight
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
A. J. G. Simpson
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
C. Kelly
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
S. R. Smithers
Affiliation:
Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA

Extract

Schistosomiasis is a chronic debilitating disease which accounts for considerable human mortality and morbidity and is second only to malaria in its prevalence and severity. Despite several years of concentrated effort to combat the disease with molluscicides and chemotherapy, schistosomiasis is still spreading, and it is thought that 500 million people are currently exposed to infection (larotski & Davis, 1981).

Type
Research Article
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bickle, Q. D., Andrews, B. J., Doenhoff, M. J., Ford, M. J. & Taylor, M.G. (1985). Resistance against Schistosoma mansoni induced by highly irradiated infections: studies on species specificity of immunization and attempts to transfer resistance. Parasitology 90, 301–12.CrossRefGoogle ScholarPubMed
Bickle, Q. D., Andrews, B. J. & Taylor, M. G. (1986). Schistosoma mansoni: characterisation of two protective monoclonal antibodies. Parasite Immunology (in the Press).CrossRefGoogle Scholar
Cheever, A. W., Hieny, S., Duvall, R. H. & Sher, A. (1983). Lack of resistance to Schistosoma japonicum in mice immunized with irradiated S. mansoni cercariae. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 812–14.CrossRefGoogle ScholarPubMed
Dame, J. B., Williams, J. L., McCutchan, T. F., Weber, J. L., Wirtz, R. A., Hockmeyer, W. T., Maloy, W. L., Haynes, J. D., Schneider, I., Roberts, D., Saunders, G. S., Reddy, E. P., Diggs, C. L. & Miller, L. H. (1984). Structure of the gene encoding the immunodominant surface antigen on the sporozoite of human malaria Plasmodium falciparum. Science 225, 593–9.CrossRefGoogle Scholar
Dissous, C., Dissous, C. & Capron, A. (1981). Isolation and characterisation of surface antigens from Schistosoma mansoni schistosomula. Molecular and Biochemical Parasitology 3, 215–25.CrossRefGoogle ScholarPubMed
Gryzch, J. M., Capron, M., Lambert, P. H., Dissous, C., Torres, S. & Capron, A. (1985). An anti-idiotype vaccine against experimental schistosomiasis. Nature, London, 316, 74–6.CrossRefGoogle Scholar
Gubler, V. & Hoffman, B. J. (1983). A simple and very efficient method of generating cDNA libraries. Gene 25, 263–9.CrossRefGoogle ScholarPubMed
Hall, R., Hyde, J. E., Goman, M., Simmons, D. L., Hope, I. A., Mackay, M. & Scaife, J., Merkli, B., Richle, R. & Stocker, J. (1984). Major surface antigen of a human malaria parasite cloned and expressed in bacteria. Nature, London 311, 379–82.CrossRefGoogle ScholarPubMed
Iarotski, L. S. & Davis, A. (1981). The schistosomiasis problem in the world: results of a WHO questionnaire survey. Bulletin of the World Health Organization 59, 115–27.Google ScholarPubMed
James, S. L., Pearce, E. J. & Sher, A. (1985). Induction of protective immunity against Schistosoma mansoni by a non-living vaccine. I. Partial characterisation of antigens recognised by antibodies from mice immunized with soluble schistosome extracts. Journal of Immunology 134, 3432–8.Google Scholar
Kelly, C., Simpson, A. J. G., Fox, E., Phillips, S. M. & Smithers, S. R. (1985). The identification of Schistosoma mansoni surface antigens recognised by protective monoclonal antibodies. Parasite Immunology (in the Press).Google Scholar
Kemp, D. J., Coppel, R. L., Cowman, R. F., Saint, R. B., Brown, G. V. & Anders, R. F. (1983). Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: Detection with antibodies from immune humans. Proceedings of the National Academy of Sciences, USA 80, 3787–91.CrossRefGoogle ScholarPubMed
Knight, M., Simpson, A. J. G., Bickle, Q., Hagan, P., Moloney, A., Welkins, A. & Smithers, S. R. (1986). Adult schistosome cDNA libraries as a source of antigens for the study of experimental and human schistosomiasis.CrossRefGoogle Scholar
Knight, M., Simpson, A. J. G., Payares, G., Chaudhri, M. & Smithers, S. R. (1984). Cell-free synthesis of Schistosoma mansoni surface antigens: stage specificity of their expression. The EMBO Journal 3, 213–19.CrossRefGoogle ScholarPubMed
Michaels, R. M. (1969). Mating of Schistosoma mansoni in vitro. Experimental Parasitology 25, 5871.Google Scholar
Payares, G., McLaren, D. J., Evans, W. H. & Smithers, S. R. (1985). Antigenicity and immunogenicity of the tegumental outer membrane of adult Schistosoma mansoni. Parasite Immunology 7, 4561.Google Scholar
Payares, G. & Simpson, A. J. G. (1986). Schistosoma mansoni surface glycoproteins: analysis of their expression and antigenicity. European Journal of Biochemistry (in the Press).Google Scholar
Sher, A., Smithers, S. R. & Mackenzie, P. (1975). Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology 70, 347–57.CrossRefGoogle ScholarPubMed
Simpson, A. J. G., Hackett, F., Kelly, C., Knight, M., Payares, G., Ali, P., Lillywhite, J., Fleck, S. L. & Smithers, S. R. (1985). The recognition of Schistosoma mansoni surface antigens by antibodies from patients infected with S. mansoni surface antigens by antibodies from patients infected with S. mansoni and S. haematobium. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).Google Scholar
Simpson, A. J. G., Hackett, F., Walker, T., de Rossi, R. & Smithers, S. R. (1985). Antibody response against schistosomulum surface antigens and protective immunity following immunization with highly irradiated cercariae of Schistosoma mansoni. Parasite Immunology 7, 133–52.CrossRefGoogle ScholarPubMed
Simpson, A.J. G., James, S. L. & Sher, A. (1983). Identification of surface antigens of schistosomula of Schistosoma mansoni recognised by antibodies from mice immunized by chronic infection and by exposure to highly irradiated cercariae. Infection and Immunity 41, 591–7.CrossRefGoogle ScholarPubMed
Simpson, A.J. G. & Knight, M. (1985). Cloning of a major developmentally regulated gene expressed in mature females of Schistosoma mansoni. Molecular and Biochemical Parasitology (in the Press).Google Scholar
Smithers, S. R. & Doenhoff, M. S. (1982). Schistosomiasis. In Immunology of Parasitic Infections (ed. Cohen, S. and Warren, K. S.), pp. 527607. London: Blackwell Scientific Publications Ltd.Google Scholar
Young, R. A., Mehra, B., Sweetser, D., Buchanan, T., Clark-Curtiss, J., Davis, R. W. & Bloom, B. R. (1985). Genes are the major protein antigens of the leprosy parasite Mycobacterium leprae. Nature, London 316, 450–2.CrossRefGoogle ScholarPubMed
Young, R. A. & Davis, R. W. (1983). Efficient isolation of genes by using antibody probes. Proceedings of the National Academy of Sciences, USA 80, 1194–8.CrossRefGoogle ScholarPubMed
Zodda, D. M. & Phillips, S. M. (1982). Monoclonal antibody-mediated protection against Schistosoma mansoni infection in mice. Journal of Immunology 129, 2326–8.CrossRefGoogle ScholarPubMed