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Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug

Published online by Cambridge University Press:  27 April 2020

Julia Fabbri ,
Patricia Eugenia Pensel ,
Clara María Albani ,
Lurdes Milagros Lopez ,
Analia Simonazzi ,
José María Bermudez ,
Santiago Daniel Palma  and
María Celina Elissondo Open the ORCID record for María Celina Elissondo [Opens in a new window]
Julia Fabbri
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Buenos Aires, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Patricia Eugenia Pensel
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Buenos Aires, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Clara María Albani
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Buenos Aires, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Lurdes Milagros Lopez
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Buenos Aires, Argentina
Analia Simonazzi
Affiliation:
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta (UNSa), Salta, Argentina
José María Bermudez
Affiliation:
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Instituto de Investigaciones para la Industria Química, Universidad Nacional de Salta (UNSa), Salta, Argentina
Santiago Daniel Palma
Affiliation:
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina Laboratorio de Farmacotecnia, Facultad de Ciencias Químicas (FCdQ), Universidad Nacional de Córdoba (UNC), Córdoba, Argentina
María Celina Elissondo*
Affiliation:
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Buenos Aires, Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
*
Author for correspondence: María Celina Elissondo, E-mail: c.elissondo@gmail.com
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Abstract

Alveolar echinococcosis is a neglected parasitic zoonosis caused by Echinococcus multilocularis. The pharmacological treatment is based on albendazole (ABZ). However, the low water solubility of the drug produces a limited dissolution rate, with the consequent failure in the treatment of the disease. Solid dispersions are a successful pharmacotechnical strategy to improve the dissolution profile of poorly water-soluble drugs. The aim of this work was to determine the in vivo efficacy of ABZ solid dispersions using poloxamer 407 as a carrier (ABZ:P407 solid dispersions (SDs)) in the murine intraperitoneal infection model for secondary alveolar echinococcosis. In the chemoprophylactic efficacy study, the ABZ suspension, the ABZ:P407 SDs and the physical mixture of ABZ and poloxamer 407 showed a tendency to decrease the development of murine cysts, causing damage to the germinal layer. In the clinical efficacy study, the ABZ:P407 SDs produced a significant decrease in the weight of murine cysts. In addition, the SDs produced extensive damage to the germinal layer. The increase in the efficacy of ABZ could be due to the improvement of water solubility and wettability of the drug due to the surfactant nature of poloxamer 407. In conclusion, this study is the basis for further research. This pharmacotechnical strategy might in the future offer novel treatment alternatives for human alveolar echinococcosis.

Keywords

Albendazolealveolar echinococcosisEchinococcus multilocularispoloxamersolid dispersions
Type
Research Article
Information
Parasitology , Volume 147 , Issue 9 , August 2020 , pp. 1026 - 1031
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Copyright
Copyright © The Author(s) 2020. Published by Cambridge University Press

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