Skip to main content Accessibility help
×
Home
Hostname: page-component-747cfc64b6-5dv6l Total loading time: 0.2 Render date: 2021-06-15T23:03:43.948Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true }

Article contents

Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats

Published online by Cambridge University Press:  25 January 2013

Y. SHINTOKU
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
T. KADOSAKA
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
E. KIMURA
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
H. TAKAGI
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
S. KONDO
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
M. ITOH
Affiliation:
Parasitology Division, Department of Infection and Immunity, Aichi Medical University, Nagakute, Aichi-ken 480-1195, Japan
Corresponding
E-mail address:

Summary

Mucosal mast cells (MMC) play a crucial role in the expulsion of Strongyloides ratti adults from the small intestine of mice. We reported the large intestinal parasitism of S. ratti in rats, and there has been no report on MMC in the large intestine of the natural host. We studied kinetics of MMC, together with eosinophils, in the upper and lower small intestines, caecum and colon of infected rats. Two distinct phases of mastocytosis were revealed: one in the upper small intestine triggered by stimulation of ‘ordinary’ adults, and the other in the colon stimulated by ‘immune-resistant’ adults that started parasitizing the colon around 19 days post-infection. In all 4 intestinal sites, the MMC peaks were observed 5–7 days after the number of adult worms became the maximum and the height of MMC peaks appeared to be dependent on the number of parasitic adults, suggesting an important role played by worms themselves in the MMC buildup.

Type
Research Article
Copyright
Copyright © Cambridge University Press 2013

Access options

Get access to the full version of this content by using one of the access options below.

References

Abe, T. and Nawa, Y. (1988). Kinetic study of mast-cell growth factor production by lymphocytes during the course of Strongyloides ratti infection in mice. Parasitology Research 74, 484488. doi: 10.1007/BF00535150.CrossRefGoogle ScholarPubMed
Abe, T., Nawa, Y. and Yoshimura, K. (1992). Protease resistant interleukin-3 stimulating components in excretory and secretory products from adult worms of Strongyloides ratti . Journal of Helminthology 66, 155158. doi: 10.1017/S0022149X0001275X.CrossRefGoogle ScholarPubMed
Abe, T., Ochiai, H., Minamishima, Y. and Nawa, Y. (1988). Induction of intestinal mastocytosis in nude mice by repeated injection of interleukin-3. International Archives of Allergy and Applied Immunology 86, 356358. doi: 10.1159/000234597.CrossRefGoogle ScholarPubMed
Abe, T., Sugaya, H., Ishida, K., Khan, W. I., Tasdemir, I. and Yoshimura, K. (1993a). Intestinal protection against Strongyloides ratti and mastocytosis induced by administration of interleukin-3 in mice. Immunology 80, 116121.Google Scholar
Abe, T., Yoshimura, K. and Nawa, Y. (1993b). Transient retention of Strongyloides ratti in the caecal mucosa during infection in mice. Immunology and Cell Biology 71, 7174. doi: 10.1038/icb.1993.7.CrossRefGoogle Scholar
Eschbach, M. L., Klemm, U., Kolbaum, J., Blankenhaus, B., Brattig, N. and Breloer, M. (2010). Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-γ production in mice. Parasite Immunology 32, 370383. doi: 10.1111/j.1365-3024.2010.01199.x.CrossRefGoogle ScholarPubMed
Ishiwata, K., Uchiyama, F., Maruyama, H., Kobayashi, T., Kurokawa, M. and Nawa, Y. (1999). Glycoconjugates and host-parasite relationship in the mucosal defense against intestinal nematodes. In Mucosal Immunology (ed. Ogra, P. L., Mestecky, J., Lamm, M. E., Strober, W., Bienenstock, J. and McGhee, J. R.), pp. 925933. Academic Press, San Diego, CA, USA.Google Scholar
Kimura, E., Shintoku, Y., Kadosaka, T., Fujiwara, M., Kondo, S. and Itoh, M. (1999). A second peak of egg excretion in Strongyloides ratti-infected rats: its origin and biological meaning. Parasitology 119, 221226.CrossRefGoogle ScholarPubMed
Korenaga, M., Nawa, Y., Mimori, T. and Tada, I. (1983). Strongyloides ratti: The role of enteral antigenic stimuli by adult worms in the generation of protective immunity in rats. Experimental Parasitology 55, 358363. doi: 10.1016/0014-4894(83)90032-2.CrossRefGoogle ScholarPubMed
Mimori, T., Nawa, Y., Korenaga, M. and Tada, I. (1982). Strongyloides ratti: Mast cell and goblet cell responses in the small intestine of infected rats. Experimental Parasitology 54, 366370. doi: 10.1016/0014-4894(82)90045-5.CrossRefGoogle ScholarPubMed
Nawa, Y., Kiyota, M., Korenaga, M. and Kotani, M. (1985). Defective protective capacity of W/Wv mice against Strongyloides ratti infection and its reconstitution with bone marrow cells. Parasite Immunology 7, 429438. doi: 10.1111/j.1365-3024.1985.tb00088.x.CrossRefGoogle ScholarPubMed
Newlands, G. F. J., Huntley, J. F. and Miller, H. R. P. (1984). Concomitant detection of mucosal mast cells and eosinophils in the intestines of normal and Nippostrongylus-immune rats. A re-evaluation of histochemical and immunocytochemical techniques. Histochemistry 81, 585589. doi: 10.1007/BF00489539.CrossRefGoogle ScholarPubMed
Olson, C. E. and Schiller, E. L. (1978). Strongyloides ratti infections in rats. I. Immunopathology. American Journal of Tropical Medicine and Hygiene 27, 521526.CrossRefGoogle ScholarPubMed
Onah, D. N. and Nawa, Y. (2000). Mucosal immunity against parasitic gastrointestinal nematodes. Korean Journal of Parasitology 38, 209236. doi: 10.3347/kjp.2000.38.4.209.CrossRefGoogle ScholarPubMed
Ovington, K. S., McKie, K., Matthaei, K. I., Young, I. G. and Behm, C. A. (1998). Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5. Immunology 95, 488493. doi: 10.1046/j.1365-2567.1998.00620.x.CrossRefGoogle ScholarPubMed
Shintoku, Y., Kimura, E., Kadosaka, T., Hasegawa, H., Kondo, S., Itoh, M. and Islam, M. Z. (2005). Strongyloides ratti infection in the large intestine of wild rats, Rattus norvegicus . Journal of Parasitology 91, 11161121. doi: 10.1645/GE-3439.1.CrossRefGoogle ScholarPubMed
Shintoku, Y., Takagi, H., Kadosaka, T., Nagaoka, F., Kondo, S., Itoh, M., Honda, S. and Kimura, E. (2011). Strongyloides ratti: transplantation of adults recovered from the small intestine at different days after infection into the colon of naive and infection-primed Wistar rats, and the effect of antioxidant treatment on large intestinal parasitism. Parasitology 138, 10531060. doi: 10.1017/S0031182011000631.CrossRefGoogle ScholarPubMed
Wilkes, C. P., Bleay, C., Paterson, S. and Viney, M. E. (2007). The immune response during a Strongyloides ratti infection of rats. Parasite Immunology 29, 339346. doi: 10.1111/j.1365-3024.2007.00945.x.CrossRefGoogle ScholarPubMed
2
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *