Hostname: page-component-77c89778f8-vsgnj Total loading time: 0 Render date: 2024-07-24T20:34:52.688Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects on abomasal function of Ostertagia circumcincta infections in sheep

Published online by Cambridge University Press:  06 April 2009

L. M. McLeay ,
N. Anderson ,
J. B. Bingley  and
D. A. Titchen
L. M. McLeay
Affiliation:
Department of Veterinary Preclinical Sciences, Parkville, Victoria 3052, Australia
N. Anderson
Affiliation:
University of Melbourne, and Animal Health Division of the C.S.I.R.O., Parkville, Victoria 3052, Australia
J. B. Bingley
Affiliation:
University of Melbourne, and Animal Health Division of the C.S.I.R.O., Parkville, Victoria 3052, Australia
D. A. Titchen
Affiliation:
Department of Veterinary Preclinical Sciences, Parkville, Victoria 3052, Australia
Get access Rights & Permissions [Opens in a new window]

Extract

Sheep in which abomasal fundic pouches had been made were infected with Ostertagia circumcincta (150000 larvae in one sheep, 100000 in three sheep). Subsequently studies were made on pouch secretion, food intake, plasma pepsinogens and abomasal pouch secretory responses when the sheep first ate. A functional abomasal lesion was apparent within 4 days of infection judged by the changes in plasma pepsinogen levels and the sodium concentrations of abomasal contents. Whereas the secretory activity of the abomasal fundic pouches (never exposed to parasites) was maintained or increased, the pH and sodium concentration of contents taken from the infected part of the abomasum were indicative of either a failure to secrete or of a permeability reabsorptive lesion. Ultrastructural studies demonstrated that parietal cells of the pouches had the appearance of cells subjected to strong secretory stimuli, but those of infected abomasa were similar to cells of gastric mucosa subjected to agents suppressing secretion. Factors which might operate, on the one hand, to stimulate secretion from separated fundic abomasal pouches, and on the other to inhibit or modify the secretory activity of the fundic mucosa of the infected abomasa, are discussed.

Type
Research Article
Information
Parasitology , Volume 66 , Issue 2 , April 1973 , pp. 241 - 257
Copyright
Copyright © Cambridge University Press 1973

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anderson, N., (1972). Trichostrongylid infections of sheep in a winter rainfall region. I. Epizootiological studies in the western district of Victoria, 1966–67. Australian Journal of Agricultural Research 23, 1113–29.CrossRefGoogle Scholar
Anderson, N., Armour, J., Jarrett, W. R. H., Jennings, F. W., Ritchie, J. D. S., & Urquhart, G. M., (1965). A field study of parasitic gastritis in cattle. Veterinary Record 77, 1196–204.CrossRefGoogle ScholarPubMed
Anderson, N., Armour, J., Eadie, R. M., Jarrett, W. F. H., Jennings, F. W., Ritchie, J. D. S., & Urquhart, G. M, (1966). Experimental Ostertagia ostertagi infections in calves:Results of single infections with five graded dose levels of larvae. American Journal of Veterinary Research 27, 1259–65.Google Scholar
Armour, J., Jarrett, W. F. H., & Jennings, F. W., (1966). Experimental Ostertagia circumcincta infections in sheep: Development and pathogenesis of a single infection. American Journal of Veterinary Research 27, 1267–78.Google Scholar
Ash, R. W., (1961). Acid secretion by the abomasum and its relation to the flow of food material in the sheep. Journal of Physiology (London) 156, 93–111.CrossRefGoogle Scholar
Caldwell, J. R., & Moyer, H. V., (1935). Industrial and engineering chemistry. Analytical Edition 7, 38–9.CrossRefGoogle Scholar
Carleton, H. M., & Drury, R. A. B., (1957). Histological Technique, 3rd ed., Oxford University Press.Google Scholar
Clayden, E. C., (1955). Practical Section Cutting and Staining, 3rd ed., London: I and A Churchill Ltd.Google Scholar
Davenport, H. W., (1964). Gastric mucosal injury by fatty and acetylsalicylic acids. Gastroenterology 46, 245–53.CrossRefGoogle ScholarPubMed
Davenport, H. W., (1965). Damage to the gastric mucosa: Effects of salicylates and stimulation. Gastroenterology 49, 189–96.Google Scholar
Davenport, H. W., (1970). Back diffusion of acid through the gastric mucosa and its physiological consequences. In Progress in Gastroenterology, vol. II (ed. Jerzy-Glas, G.), New York: Grune and Stratton Inc. pp. 42–56.Google Scholar
Denham, D. A., (1969). The development of Ostertagia circumcincta in lambs. Journal of Helminthology 43, 299–310.CrossRefGoogle ScholarPubMed
Edwards, K., Jepson, R. P., & Wood, K. F., (1960). The value of plasma pepsinogen estimation. British Medical Journal 1, 30–2.CrossRefGoogle ScholarPubMed
Gordon, H. McL., & Whitlock, H. V, (1939). A new technique for counting nematode eggs in sheep faeces. Journal of the Council for Scientific and Industrial Research, Australia 12, 50–2.Google Scholar
Grossman, M. I, (1970). Gastrin and its activities. Nature 228, 1147–50.Google Scholar
Harrop, C. J. F., & Pkellipson, A. T., (1971). The effects of diet and pentagastrin on the influx of urea into the rumen. Proceedings of the Nutrition Society 30, 3–4 A.Google Scholar
Hill, K. J., (1968). Abomasal function. Chapter 131, pp. 2747–60, in Handbook of Physiology, Section 6: Alimentary Tract; Vol. v: Bile; Digestion; Ruminal Physiology. Washington, D.C.: American Physiological Society.Google Scholar
Holmes, P. H., & Maclean, J. M., (1971). The pathophysiology of ovine ostertagiasis: A study of the changes in plasma protein metabolism following single infections. Research in Veterinary Science 12, 265–71.Google Scholar
Hunt, J. N., & Wan, B., (1967). Electrolytes of mammalian gastric juice. Chapter 44, pp. 781–804, in Handbook of Physiology, Section 6: Alimentary Tract; Vol. II: Secretion. Washington, D.C.: American Physiological Society.Google Scholar
Ivey, K. J., (1971). Gastric mucosal barrier. Gastroenterology 61, 247–57.CrossRefGoogle ScholarPubMed
McLeay, L. M., (1971). Gastric secretion in the sheep, Thesis, University of Melbourne.Google Scholar
McLeay, L. M., & Titchen, D. A., (1970a). Abomasal secretory responses to teasing with food and feeding in the sheep. Journal of Physiology (London) 206, 605–28.Google Scholar
McLeay, L. M., & Titchen, D. A., (1970b). Effects of pentagastrin on gastric secretion and motility in the sheep. Proceedings of the Australian Physiological and Pharmacological Society 1 (1), 33–4.Google Scholar
McLeay, L. M., & Titchen, D. A., (1971). Antral control of gastric acid and pepsin secretion in the sheep. Proceedings of the International Union of Physiological Sciences 9, 382.Google Scholar
Mulligan, W., Dalton, R., & Anderson, N., (1963). Ostertagiasis in cattle. Veterinary Record 75, 1014.Google Scholar
Murray, M., (1969). Structural changes in bovine ostertagiasis associated with increased permeability of the bowel wall to macromolecules. Gastroenterology 56, 763–71.Google Scholar
Murray, M., Jennings, F. W., & Armour, J., (1970). Bovine ostertagiasis: Structure, function and mode of differentiation of the bovine gastric mucosa and kinetics of the worm loss. Research in Veterinary Science 11, 417–27.CrossRefGoogle ScholarPubMed
Ritchie, J. D. S., Anderson, N., Armour, J., Jarrett, W. F. H., Jennings, F. W., & Urquhart, G. M., (1966). Experimental Ostertagia ostertagi infections in calves: Parasitology and pathogenesis of a single infection. American Journal of Veterinary Research 27, 659–67.Google Scholar
Sedar, A. W., & Friedman, M. H. F., (1961). Correlation of the fine structure of the gastric parietal cell (dog) with functional activity of the stomach. Journal of Biophysical and Biochemical Cytology 11, 349–63.CrossRefGoogle ScholarPubMed
Sommerville, R. I., (1954). The histotrophic phase of the nematode parasite Ostertagia circumcincta. Australian Journal of Agricultural Research 5, 130–40.Google Scholar
Williams, E. M. Vaughan, (1954). The mode of action of drugs upon intestinal motility. Pharmacological Reviews 6, 159–90.Google Scholar
Vial, J. D., & Orrego, H., (1960). Electron microscope observations on the fine structure of parietal cells. Journal of Biophysical and Biochemical Cytology 7, 367–72.Google Scholar