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The anti-haemostatic strategies of the human hookworm Necator americanus

Published online by Cambridge University Press:  06 April 2009

B. A. Furmidge ,
L. A. Horn  and
D. I. Pritchard
B. A. Furmidge
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
L. A. Horn
Affiliation:
Department of Therapeutics, Queen's Medical Centre, Nottingham
D. I. Pritchard
Affiliation:
Department of Life Science, University of Nottingham, University Park, Nottingham NG7 2RD
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Summary

The human hookworm Necator americanus appears to have evolved a number of complementary strategies to overcome the host's haemostatic processes. These include the inhibition of blood coagulation, platelet aggregation and mediator release, and the secretion of fibrinogenolytic enzymes. These strategies presumably allow the parasite to establish the chronic infections so often documented in human populations.

Keywords

human hookwormsNecator americanuscoagulationplatelet.
Type
Research Article
Information
Parasitology , Volume 112 , Issue 1 , January 1996 , pp. 81 - 87
Copyright
Copyright © Cambridge University Press 1996

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