There is growing evidence of an escalation of depression in young people. In light of this, schools are increasingly being confronted with the challenge of how to best manage students with depressive disorders. Such management includes consideration of the academic, behavioural, social and emotional implications of the disorder. This article provides school practitioners and management with a review of what constitutes ‘best practice’ in school management of students with depressive disorders. It adopts the mental health intervention framework of the Institute of Medicine, considering how school-based intervention occurs across the four domains of mental health promotion, prevention, case identification and treatment, as well as maintenance of students with or at-risk of depression. It provides a checklist for practitioners at each stage of the Institute of Medicine intervention spectrum. Moreover, it takes the view that best practice in psychology is always evidence-based practice, although discerning a clear path through the available research is not always obvious.