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Synthesis and characterization of citrus-derived pectin nanoparticles based on their degree of esterification

Published online by Cambridge University Press:  04 June 2020

Eden Mariam Jacob ,
Ankita Borah ,
Amandeep Jindal ,
Sindhu C. Pillai ,
Yohei Yamamoto ,
Toru Maekawa  and
Dasappan Nair Sakthi Kumar Open the ORCID record for Dasappan Nair Sakthi Kumar [Opens in a new window]
Eden Mariam Jacob
Affiliation:
Graduate School of Interdisciplinary New Science, Bio Nano Electronic Research Centre, Toyo University, Kawagoe, Saitama350-8585, Japan
Ankita Borah
Affiliation:
Graduate School of Interdisciplinary New Science, Bio Nano Electronic Research Centre, Toyo University, Kawagoe, Saitama350-8585, Japan
Amandeep Jindal
Affiliation:
Department of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki305-8573, Japan
Sindhu C. Pillai
Affiliation:
Graduate School of Interdisciplinary New Science, Bio Nano Electronic Research Centre, Toyo University, Kawagoe, Saitama350-8585, Japan
Yohei Yamamoto
Affiliation:
Department of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki305-8573, Japan
Toru Maekawa
Affiliation:
Graduate School of Interdisciplinary New Science, Bio Nano Electronic Research Centre, Toyo University, Kawagoe, Saitama350-8585, Japan
Dasappan Nair Sakthi Kumar*
Affiliation:
Graduate School of Interdisciplinary New Science, Bio Nano Electronic Research Centre, Toyo University, Kawagoe, Saitama350-8585, Japan
*
a)Address all correspondence to this author. e-mail: sakthi@toyo.jp
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Abstract

Polysaccharide-based nanoparticles such as pectin had always been of greatest interest because of its excellent solubility and mucoadhesive nature and are highly suitable for oral drug delivery for drug administration. In this study, we used commercially available pectin samples based on their degree of esterification, and nanoparticles were fabricated by the ionotropic gelation method using magnesium (Mg2+) as the divalent cross-linker. We conducted a comparative analysis on the three pectin NPs—high methoxylated pectin (HMP), low methoxylated pectin (LMP), and amidated LMP (AMP)—to examine the difference in characteristics such as shape, size, and biocompatibility. HMP and AMP were found to be similar in size (~850 nm), whereas LMP was found to be of ~700 nm. The three NPs were also tested for their biocompatibility toward THP-1 cells. All three NPs were found to have the potential as a nanocarrier of therapeutic and preventive drugs, especially through oral routes.

Keywords

pectin nanoparticlesionotropic gelationoral drug delivery
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 12 , 29 June 2020 , pp. 1514 - 1522
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Copyright © Materials Research Society 2020

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