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Regenerative medicine: Induced pluripotent stem cells and their benefits on accelerated bone tissue reconstruction using scaffolds

Published online by Cambridge University Press:  22 May 2018

Nowsheen Goonoo  and
Archana Bhaw-Luximon
Nowsheen Goonoo
Affiliation:
Biomaterials, Drug Delivery and Nanotechnology Unit, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit 80837, Mauritius
Archana Bhaw-Luximon*
Affiliation:
Biomaterials, Drug Delivery and Nanotechnology Unit, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Réduit 80837, Mauritius
*
a)Address all correspondence to this author. e-mail: a.luximon@uom.ac.mu, abluximon@gmail.com
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Abstract

Induced pluripotent stem cells (iPSCs) offer the possibility to accelerate tissue reconstruction through cell differentiation. The use of iPSCs in bone tissue engineering is promoted by next generation scaffolds which guide bone tissue repair and provide specific cues and molecular recognition to enhance differentiation as well as the bone forming ability of these cells. However, bone tissue repair faces additional challenges such as requirement for a consequent bone vasculature and exhaustion of stem cells in the aging adults. In this context, iPSC reprogramming seems to be unaffected by age and they have better pro-angiogenic potential as well as proliferation rate. The benefits of iPSCs using polymeric scaffolds include access to humanized in vitro models, triggering bone tissue reconstruction through a supply of bone cells via differentiation, compensating mesenchymal stem cells age-related deficiencies in osteodegenerative diseases, and enhancing angiogenesis.

Keywords

bonebiomedicalcellular
Type
REVIEW
Information
Journal of Materials Research , Volume 33 , Issue 11 , 13 June 2018 , pp. 1573 - 1591
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Copyright
Copyright © Materials Research Society 2018 

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Footnotes

This section of Journal of Materials Research is reserved for papers that are reviews of literature in a given area.

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