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Cell viability assessments of green synthesized water-soluble AgInS2/ZnS core/shell quantum dots against different cancer cell lines

Published online by Cambridge University Press:  09 December 2019

Oluwatobi S. Oluwafemi ,
Bambesiwe M.M. May ,
Sundararajan Parani  and
Jose Varghese Rajendran
Oluwatobi S. Oluwafemi*
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa; and Centre for Nanomaterials Science Research, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa
Bambesiwe M.M. May
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa; and Centre for Nanomaterials Science Research, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa
Sundararajan Parani
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa; and Centre for Nanomaterials Science Research, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa
Jose Varghese Rajendran
Affiliation:
Department of Chemical Sciences (formerly Applied Chemistry), University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa; and Centre for Nanomaterials Science Research, University of Johannesburg, Doornfontein 2028, Johannesburg, South Africa
*
a)Address all correspondence to this author. e-mail: oluwafemi.oluwatobi@gmail.com
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Abstract

Chalcopyrite quantum dots (QDs) have emerged as a safe alternative to cadmium-based QDs for bio-applications. However, the research on AgInS2 chalcopyrite QDs has not been widely explored in terms of their toxicity. Herein, we report a synthesis of biocompatible AgInS2/ZnS QDs via a greener approach. The emission intensity of the as-synthesized AgInS2 core QDs was enhanced 2-fold after the ZnS shell growth. X-ray diffraction revealed the tetragonal crystal structure of QDs, and high-resolution transmission electron microscope images show that the QDs are spherical in shape and crystalline in nature. Cell viability assays conducted on different cell lines, such as HeLa, A549, and BHK-21 cells, indicated that AgInS2/ZnS QDs are least toxic at a QD concentration range of 100 µg/mL. The fluorescent microscope analysis of A549 cells incubated with AgInS2/ZnS QDs shows that the QDs were accumulated in the cell membranes. The as-synthesized AgInS2/ZnS QDs are less toxic and eco-friendly, and can be used for biolabeling.

Keywords

core/shellbiologicalnanostructure
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 24 , 30 December 2019 , pp. 4037 - 4044
Copyright
Copyright © Materials Research Society 2019 

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