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Mixed micelles from synergistic self-assembly of hybrid copolymers with charge difference electrostatic interaction induced re-organization of micelles from hybrid copolymers

Published online by Cambridge University Press:  04 July 2016

Yiting Xu
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen 361005, People's Republic of China, and Department of Materials Science and Engineering, Xiamen University, Xiamen 361005, People's Republic of China
Ying Cao
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen
Jianjie Xie
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen
Qi Li
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen
Xianming Chen
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen
Shiao-Wei Kuo
Affiliation:
Department of Materials and Optoelectronic Science, Center for Nanoscience and Nanotechnology, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
Lizong Dai
Affiliation:
Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen
Corresponding
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Abstract

Novel mixed micelle was successfully fabricated by the synergistic self-assembly of poly(methacrylate isobutyl polyhedral oligomeric silsesquioxane (POSS)-co-N-isopropylacrylamide-co-oligo(ethylene glycol)methyl ether methacrylate-co-acrylic acid) (P(methacrylate isobutyl (MAPOSS)-co-NIPAM-co-OEGMA-co-AA)) and poly(methacrylate isobutyl POSS-co-N-isopropylacrylamide-co-oligo(ethylene glycol) methyl ether methacrylate-co-2-vinylpyridine) (P(MAPOSS-co-NIPAM-co-OEGMA-co-2VP)). Dynamic light scattering (DLS) and transmission electron microscopy characterizations demonstrate that the formation of mixed micelles is driven by electrostatic interaction. The formation of the mixed micelles was further implied by a simple fluorescence resonance energy transfer based technique. The mixed micelle possesses the biggest size at pH = 7.0, which is attributed to the strongest electrostatic interaction between the two kinds of micelles. The zeta potential under different pH was detected to further investigate the surface charges corroborating the discussions. DLS and UV-vis indicate that the lower critical solution temperature (LCST) is pH dependent. The mixed micelles reach the highest LCST at pH 7.0. The LCST of the mixed micelle can be tuned by adjusting the volume ratio of the two kinds of micelles as well. Moreover, the thermo-responsive behavior of the mixed micelle is absolutely reversible.

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Copyright
Copyright © Materials Research Society 2016 

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Footnotes

Contributing Editor: Tao Xie

References

Upadhyay, K.K., Agrawal, H., Upadhyay, C., Schatz, C., Le Meins, J-F., Misra, A., and Lecommandoux, S.: Role of block copolymer nanoconstructs in cancer therapy. Crit. Rev. Ther. Drug Carrier Syst. 26(2), 157 (2009).CrossRefGoogle ScholarPubMed
Ikkala, O. and Ten Brinke, G.: Hierarchical self-assembly in polymeric complexes: Towards functional materials. Chem. Commun. 10(19), 2131 (2004).CrossRefGoogle Scholar
Yu, Y. and Eisenberg, A.: Control of morphology through polymer–solvent interactions in crew-cut aggregates of amphiphilic block copolymers. J. Am. Chem. Soc. 119(35), 8383 (1997).CrossRefGoogle Scholar
Zhang, L., Yu, K., and Eisenberg, A.: Ion-induced morphological changes in “crew-cut” aggregates of amphiphilic block copolymers. Science 272(5269), 1777 (1996).CrossRefGoogle ScholarPubMed
Zhang, L. and Eisenberg, A.: Multiple morphologies and characteristics of “crew-cut” micelle-like aggregates of polystyrene-b-poly (acrylic acid) diblock copolymers in aqueous solutions. J. Am. Chem. Soc. 118(13), 3168 (1996).CrossRefGoogle Scholar
Schild, H.G.: Poly(N-isopropylacrylamide): Experiment, theory and application. Prog. Polym. Sci. 17(2), 163 (1992).CrossRefGoogle Scholar
Rodriguez-Hernandez, J., Chécot, F., Gnanou, Y., and Lecommandoux, S.: Toward “smart” nano-objects by self-assembly of block copolymers in solution. Prog. Polym. Sci. 30, 691 (2005).CrossRefGoogle Scholar
Soppimath, K., Aminabhavi, T., Dave, A., Kumbar, S., and Rudzinski, W.: Stimulus-responsive “smart” hydrogels as novel drug delivery systems. Drug Dev. Ind. Pharm. 28(8), 957 (2002).CrossRefGoogle ScholarPubMed
Pinkrah, V., Snowden, M., Mitchell, J., Seidel, J., Chowdhry, B., and Fern, G.: Physicochemical properties of poly(N-isopropylacrylamide-co-4-vinylpyridine) cationic polyelectrolyte colloidal microgels. Langmuir 19(3), 585 (2003).CrossRefGoogle Scholar
Torres-Lugo, M. and Peppas, N.A.: Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 32(20), 6646 (1999).CrossRefGoogle Scholar
He, C., Zhao, C., Guo, X., Guo, Z., Chen, X., Zhuang, X., Liu, S., and Jing, X.: Novel temperature-and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide). J. Polym. Sci., Part A: Polym. Chem. 46(12), 4140 (2008).CrossRefGoogle Scholar
Ayres, N., Cyrus, C.D., and Brittain, W.J.: Stimuli-responsive surfaces using polyampholyte polymer brushes prepared via atom transfer radical polymerization. Langmuir 23(7), 3744 (2007).CrossRefGoogle ScholarPubMed
Zhang, W., Shi, L., Ma, R., An, Y., Xu, Y., and Wu, K.: Micellization of thermo-and pH-responsive triblock copolymer of poly(ethylene glycol)-b-poly (4-vinylpyridine)-b-poly(N-isopropylacrylamide). Macromolecules 38(21), 8850 (2005).CrossRefGoogle Scholar
Pottier, C., Morandi, G., Dulong, V., Souguir, Z., Picton, L., and Le Cerf, D.: Thermo-and pH-sensitive triblock copolymers with tunable hydrophilic/hydrophobic properties. J. Polym. Sci., Part A: Polym. Chem. 53(22), 2606 (2015).CrossRefGoogle Scholar
Li, G., Shi, L., Ma, R., An, Y., and Huang, N.: Formation of complex micelles with double-responsive channels from self-assembly of two diblock copolymers. Angew. Chem. 118(30), 5081 (2006).CrossRefGoogle Scholar
Lee, Y., Ishii, T., Cabral, H., Kim, H.J., Seo, J.H., Nishiyama, N., Oshima, H., Osada, K., and Kataoka, K.: Inside cover: Charge-conversional polyionic complex micelles—Efficient nanocarriers for protein delivery into cytoplasm. Angew. Chem., Int. Ed. 48(29), 5220 (2009).CrossRefGoogle Scholar
Kuo, S.W., Tung, P.H., Lai, C.L., Jeong, K.U., and Chang, F.C.: Supramolecular micellization of diblock copolymer mixtures mediated by hydrogen bonding for the observation of separated coil and chain aggregation in common solvents. Macromol. Rapid Commun. 29(3), 229 (2008).CrossRefGoogle Scholar
Chen, D. and Jiang, M.: Strategies for constructing polymeric micelles and hollow spheres in solution via specific intermolecular interactions. Acc. Chem. Res. 38, 494 (2005).CrossRefGoogle ScholarPubMed
Hsu, C-H., Kuo, S-W., Chen, J-K., Ko, F-H., Liao, C-S., and Chang, F-C.: Self-assembly behavior of AB diblock and CD random copolymer mixtures in the solution state through mediated hydrogen bonding. Langmuir 24(15), 7727 (2008).CrossRefGoogle Scholar
Kang, N., Perron, M-È., Prud'Homme, R.E., Zhang, Y., Gaucher, G., and Leroux, J-C.: Stereocomplex block copolymer micelles: Core–shell nanostructures with enhanced stability. Nano Lett. 5(2), 315 (2005).CrossRefGoogle ScholarPubMed
Attia, A.B.E., Ong, Z.Y., Hedrick, J.L., Lee, P.P., Ee, P.L.R., Hammond, P.T., and Yang, Y-Y.: Mixed micelles self-assembled from block copolymers for drug delivery. Curr. Opin. Colloid Interface Sci. 16(3), 182 (2011).CrossRefGoogle Scholar
Wu, C., Ma, R., He, H., Zhao, L., Gao, H., An, Y., and Shi, L.: Fabrication of complex micelles with tunable shell for application in controlled drug release. Macromol. Biosci. 9(12), 1185 (2009).CrossRefGoogle ScholarPubMed
Hussain, H., Tan, B., Mya, K.Y., Liu, Y., He, C., and Davis, T.P.: Synthesis, micelle formation, and bulk properties of poly(ethylene glycol)-b-poly(pentafluorostyrene)-g-polyhedral oligomeric silsesquioxane amphiphilic hybrid copolymers. J. Polym. Sci., Part A: Polym. Chem. 48(1), 152 (2010).CrossRefGoogle Scholar
Tan, B., Hussain, H., and He, C.: Tailoring micelle formation and gelation in (PEG−P(MA-POSS)) amphiphilic hybrid block copolymers. Macromolecules 44(3), 622 (2011).CrossRefGoogle Scholar
Zheng, Y., Wang, L., Yu, R., and Zheng, S.: Synthesis and self-assembly behavior of organic–inorganic poly(ethylene oxide)-block-poly(MA POSS)-block-poly(N-isopropylacrylamide) triblock copolymers. Macromol. Chem. Phys. 213(4), 458 (2012).CrossRefGoogle Scholar
Alves, F. and Nischang, I.: A simple approach to hybrid inorganic–organic step-growth hydrogels with scalable control of physicochemical properties and biodegradability. Polym. Chem. 6(12), 2183 (2015).CrossRefGoogle ScholarPubMed
Xu, Y., Chen, M., Xie, J., Li, C., Yang, C., Deng, Y., Yuan, C., Chang, F-C., and Dai, L.: Synthesis, characterization and self-assembly of hybrid pH-sensitive block copolymer containing polyhedral oligomeric silsesquioxane (POSS). React. Funct. Polym. 73(12), 1646 (2013).CrossRefGoogle Scholar
Chiefari, J., Chong, Y., Ercole, F., Krstina, J., Jeffery, J., Le, T.P., Mayadunne, R.T., Meijs, G.F., Moad, C.L., and Moad, G.: Living free-radical polymerization by reversible addition-fragmentation chain transfer: the RAFT process. Macromolecules 31(16), 5559 (1998).CrossRefGoogle Scholar
Xu, Y., Xie, J., Chen, L., Yuan, C., Pan, Y., Cheng, L., Luo, W., Zeng, B., and Dai, L.: A Novel Hybrid Random Copolymer Poly(MAPOSS-co-NIPAM-co-OEGMA-co-2VP): Synthesis, Characterization, Self-Assembly Behaviors and Multiple Responsive Properties. Macromol. Res. 21, 1338 (2013).CrossRefGoogle Scholar
Jiwpanich, S., Ryu, J-H., Bickerton, S., and Thayumanavan, S.: Noncovalent encapsulation stabilities in supramolecular nanoassemblies. J. Am. Chem. Soc. 132(31), 10683 (2010).CrossRefGoogle ScholarPubMed
Dinarvand, R. and D'Emanuele, A.: The use of thermoresponsive hydrogels for on-off release of molecules. J. Controlled Release 36(3), 221 (1995).CrossRefGoogle Scholar

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