Objectives: The cost-effectiveness of computed tomographic (CT) scanning after acute stroke was investigated to assess the contribution of brain imaging to the diagnosis and management of stroke and to estimate the costs, benefits, and risks of different imaging strategies to provide data to inform national and local policy on the use of brain imaging in stroke.

Objectives: A systematic review of the effectiveness and costs of different guideline development, dissemination, and implementation strategies wasundertaken. The resource implications of these strategies was estimated, and a framework for deciding when it is efficient to develop and introduce clinical guidelines was developed.

Objectives: The objectives were to ascertain the value of a range of methods—including clinical features, resting and exercise electrocardiography, and rapid access chest pain clinics (RACPCs)—used in the diagnosis and early management of acute coronary syndrome (ACS), suspected acute myocardial infarction (MI), and exertional angina.

Objectives: The clinical- and cost-effectiveness of tandem mass spectrometry (MS)-based neonatal screening for inborn errors of metabolism (IEM) were evaluated.

To the Editor: I read with interest the research note by Saunders (2) in the Summer 2003 issue of International Journal of Technology Assessment in Health Care. Although this article was published in 2003 and stated to have been a thorough review of hyperbaric oxygen randomized clinical trials, our double-blind randomized control trial in acute carbon monoxide poisoning published in 2002 (4) was not mentioned, except as a blinded interim analysis (3). Our randomized clinical trial was considered a landmark study by Journal Watch–Emergency Medicine (1). Our clinical trial demonstrated a 46 percent reduction in cognitive sequelae at 6 weeks following poisoning, which was maintained 1 year after poisoning.