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Underdiagnosis of Bipolar Disorder in Patients with Primary Diagnoses of Schizophrenia and Recurrent Depressive Disorder in Russian Federation (Observational, Non-interventional, Multicenter, Cross-sectional Diagnostic Study Maria).

Published online by Cambridge University Press:  15 April 2020

S.N. Mosolov ,
N.V. Govorin ,
A.A. Ovchinnikov ,
R.G. Agzhigitov ,
E.V. Gushanskaya ,
A.A. Shafarenko  and
M.A. Orlova
S.N. Mosolov
Affiliation:
Department for Therapy of Mental Disorders, Moscow Research Institute of Psychiatry, Moscow, Russia
N.V. Govorin
Affiliation:
Department of Psychaitry, Chita State Medical Academy, Chita, Russia
A.A. Ovchinnikov
Affiliation:
Department of Psychaitry, Novosibirsk State Medical University, Novosibirsk, Russia
R.G. Agzhigitov
Affiliation:
Department of Psychaitry, Specialized clinical hospital No.8 n.a. Z.P. Solovyov, Moscow, Russia
E.V. Gushanskaya
Affiliation:
Department of Psychiatry, Moscow Psychiatric Hospital No.13, Moscow, Russia
A.A. Shafarenko
Affiliation:
Department for Therapy of Mental Disorders, Moscow Research Institute of Psychiatry, Moscow, Russia
M.A. Orlova
Affiliation:
Medical Department, AstraZeneca Pharmaceuticals, Moscow, Russia

Abstract

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Introduction

The Bipolar Disorder (BD) is underdiagnosed condition worldwide. In Russia BD-II is mostly diagnosed as recurrent depressive disorder (RDD), and most cases of mania or depression with psychotic symptoms (so-called affective-delusional states) have diagnosis of schizophrenia.

Objective

To evaluate BD symptoms within the cohorts of inpatients with primary diagnoses of schizophrenia or RDD.

Methods

Patients with primary diagnosis of schizophrenia, schizoaffective disorder RDD were included. Bipolarity Index (BI) was the primary variable. Mini International Neuropsychiatric Interview (MINI) was used as a diagnostic tool. Personal and Social Performance Scale (PSP), Hypomania Checklist (HCL-32), Angst criteria for bipolarity were used for evaluation. Medical history, demographic and clinical data were analyzed.

Results

From 741 patients included in the study, only 12% of them reached diagnostic validity for BD using only BI (score ≥60). Using MINI and clinical data the diagnosis was revised to BD in 286 patients (38.6%). BD-I was diagnosed mostly in patients with former diagnosis of acute schizophrenia, BD-II was diagnosed exclusively in patients with former diagnosis of RDD. Mean PSP score in patients with BD was significantly higher (61.5±17.4 score) than in patients with the diagnosis of psychotic syndrome (39.3±16.2) and closer to that one in patients with RDD (63.0±16.8).

Conclusions

In our study BI has not shown to be proper screening instrument for bipolar spectrum disorders. BD is underdiagnosed in Russia.

ClinicalTrials.gov Identifier: NCT01028196.

Supported by funding from AstraZeneca Pharmaceuticals.

Type
Article: 0560
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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