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Tardive dyskinesia induced by quetiapine and confirmed by a Dat-scan

Published online by Cambridge University Press:  16 April 2020

E.N. Rizos ,
S. Chatziioannou ,
M. Kallergi ,
A. Douzenis ,
A. Apostolopoulos ,
S. Bacalis ,
V. Kontaxakis  and
L. Lykouras
E.N. Rizos
Affiliation:
2nd Department of Psychiatry, ‘ATTIKON’ General Hospital, Medical School, University of Athens, Athens, Greece
S. Chatziioannou
Affiliation:
2nd Department of Radiology, Nuclear Medicine Section, University of Athens, Medical School, Athens, Greece
M. Kallergi
Affiliation:
3. Department of Medical Instrumentation Technology, Technological Educational Institute of Athens, Athens, Greece
A. Douzenis
Affiliation:
2nd Department of Psychiatry, ‘ATTIKON’ General Hospital, Medical School, University of Athens, Athens, Greece
A. Apostolopoulos
Affiliation:
2nd Department of Psychiatry, ‘ATTIKON’ General Hospital, Medical School, University of Athens, Athens, Greece
S. Bacalis
Affiliation:
2nd Department of Radiology, Nuclear Medicine Section, University of Athens, Medical School, Athens, Greece
V. Kontaxakis
Affiliation:
2nd Department of Psychiatry, ‘ATTIKON’ General Hospital, Medical School, University of Athens, Athens, Greece
L. Lykouras
Affiliation:
2nd Department of Psychiatry, ‘ATTIKON’ General Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece

Abstract

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Background

Tardive dyskinesia is a serious side effect of antipsychotics’ activity. Imaging of the dopamine transporter could demonstrate the possible involvement of dopaminergic pathway in the appearance of tardive dyskinesia.

Methods/results

We report a case with paranoid schizophrenia and tardive dyskinesia symptoms. A first trial with quetiapine improved TD symptoms while an increase of its dose after a relapse of the underlying disease deteriorated the TD symptoms. Following that, sertindole was initiated which led to improvement of both psychotic and TD symptoms. A DAT scan showed physiologic distribution in the basal ganglia. Six months later after a serious cardiac syncope, sertindole was discontinued. Quetiapine was then started which led again to TD symptoms. A second DAT scan showed decreased dopamine transporter uptake in the area of basal ganglia.

Conclusion

We conclude that decreased dopamine transporter uptake seemed to associate with the deterioration of TD.

Type
P02-355
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 951
Copyright
Copyright © European Psychiatric Association 2011
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