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T102C and –1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive–compulsive disorder

Published online by Cambridge University Press:  16 April 2020

Şenel Tot ,
M. Emin Erdal ,
Kemal Yazıcı ,
Aylin Ertekin Yazıcı  and
Özmen Metin
Şenel Tot*
Affiliation:
Department of Psychiatry, Mersin University Faculty of Medicine, Mersin, Turkey
M. Emin Erdal
Affiliation:
Department of Medical Biology and Genetics, Mersin University Faculty of Medicine, Mersin, Turkey
Kemal Yazıcı
Affiliation:
Department of Psychiatry, Mersin University Faculty of Medicine, Mersin, Turkey
Aylin Ertekin Yazıcı
Affiliation:
Department of Psychiatry, Mersin University Faculty of Medicine, Mersin, Turkey
Özmen Metin
Affiliation:
Department of Psychiatry, Mersin University Faculty of Medicine, Mersin, Turkey
*
2Corresponding author. Mersin Üniversitesi Tıp Fakültesi Hastanesi, Psikiyatri Anabilim Dalı, Zeytinlibahçe cad, 33070 Mersin,Turkey. seneltot@mersin.edu.tr
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Abstract

Objective

This study aimed to investigate the possible association between T102C and –1438 G/A polymorphism in the 5-HT2A receptor gene and susceptibility to and clinical features of obsessive–compulsive disorder (OCD).

Method

Fifty-eight patients with OCD and 83 healthy controls were included in the study. All patients were interviewed and rated by Yale-Brown Obsessive–Compulsive Scale. T102C and –1438 G/A polymorphisms of 5-HT2A receptor gene were determined by PCR technique in DNAs of peripheral leucocytes.

Results

OCD patients and healthy controls did not show significant differences in genotype distribution for both polymorphisms investigated. We found that frequencies of the TT genotype for T102C polymorphism and the AA genotype for –1438 G/A polymorphism were significantly higher in patients with severe OCD compared to those with moderate or moderate–severe OCD.

Conclusion

The –1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD. Our data suggest that the TT genotype of T102C and the AA genotype of –1438 G/A polymorphism might be a factor in clinical severity of OCD.

Keywords

–1438 G/ASerotoninOCDPolymorphismT102C
Type
Original article
Information
European Psychiatry , Volume 18 , Issue 5 , August 2003 , pp. 249 - 254
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2003

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