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Subcortical Structures in Suicide Attempters with Bipolar Disorder, Type I
Published online by Cambridge University Press: 23 March 2020
Abstract
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Introduction
Suicidality is a major health concern with as yet unclear neurobiology.
Objectives
To identify emotional correlates of suicidality in bipolar disorder I (BD-I).
Aims
To detect subcortical structural morphology changes associated with suicide attempts.
Methods
We enrolled 30 patients with BD-I of which 15 had history of suicide attempts, and 15 healthy controls (HCs) with no such history. Groups were defined according to suicide attempt history and psychopathology. Subcortical gray matter volumes were obtained from 3 T structural MRI scans using FreeSurfer. Intergroup differences were investigated through ANOVAs followed by post hoc Fischer's least significant difference.
Results
HCs had larger left hippocampal and left accumbens volumes than both BD-I attempters and nonattempters. BD-I attempters had smaller left hippocampi and larger left amygdala than both nonattempters and HCs.
Conclusions
Differences were observed in emotional processing mediating neural circuitries, with BD-I attempters showing opposite patterns to nonattempters between amygdala and hippocampus.
Disclosure of interest
The authors have not supplied their declaration of competing interest.
- Type
- Oral communications: Bipolar disorders
- Information
- European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S77
- Copyright
- Copyright © European Psychiatric Association 2017
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