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Social cognition as a mediator between cognitive reserve and psychosocial functioning in patients with first episode psychosis

Published online by Cambridge University Press:  13 August 2021

I. González-Ortega ,
S. Alberich-Mesa ,
E. Echeburúa ,
M. Bernardo ,
B. Cabrera ,
S. Amoretti ,
A. Lobo ,
C. Arango ,
I. Corripio  and
E. Vieta
...Show all authors
I. González-Ortega*
Affiliation:
Department Of Psychiatry, Araba University Hospital, Araba University Hospital, BIOARABA RESEARCH INSTITUTE, University OF THE BASQUE COUNTRY, CIBERSAM, Vitoria-Gasteiz, Spain
S. Alberich-Mesa
Affiliation:
Departametn Of Psychiatry, Araba University Hospital, Araba University Hospital, BIOARABA RESEARCH INSTITUTE, University OF THE BASQUE COUNTRY, CIBERSAM, Vitoria-Gasteiz, Spain
E. Echeburúa
Affiliation:
Departametn Of Psychiatry, Araba University Hospital, Araba University Hospital, BIOARABA RESEARCH INSTITUTE, University OF THE BASQUE COUNTRY, CIBERSAM, Vitoria-Gasteiz, Spain Psychology, UNIVERSITY OF THE BASQUE COUNTRY, BIODONOSTIA, CIBERSAM, San Sebastián, Spain
M. Bernardo
Affiliation:
Psychiatry, Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, CIBERSAM, Barcelona, Spain
B. Cabrera
Affiliation:
Psychiatry, Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, CIBERSAM, Barcelona, Spain
S. Amoretti
Affiliation:
Psychiatry, Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic of Barcelona, CIBERSAM, Barcelona, Spain
A. Lobo
Affiliation:
Medicine And Psychiatry, University of Zaragoza, Aragon Institute for Health Sciences (IIS Aragón), Zaragoza, Spain
C. Arango
Affiliation:
Child And Adolescent Department. Institute Of Psychiatry And Mental Health, Hospital General Universitario Gregorio Marañón. CIBERSAM, Madrid, Spain
I. Corripio
Affiliation:
Psychiatry, Institut d’Investigació Biomèdica-Sant Pau (IIB-SANT PAU), Barcelona, Spain
E. Vieta
Affiliation:
Institute Of Neuroscience, Hospital Clinic, University Of Barcelona, Bipolar and Depressive Disorders Unit, IDIBAPS, CIBERSAM, Barcelona, Spain
E. De La Serna
Affiliation:
Child And Adolescent Psychiatry, Hospital Clinic of Barcelona, CIBERSAM, Barcelona, Spain
R. Rodriguez-Jimenez
Affiliation:
Psychiatry, 12 de Octubre Hospital Research Institute, CIBERSAM, Madrid, Spain
R. Segarra
Affiliation:
Neurosciences, University of the Basque Country, Cruces University Hospital, Biocruces Bizkaia Health Research Institute, CIBERSAM, Leioa, Spain
J.M. López-Ilundain
Affiliation:
Psychiatry, Navarre Hospital Complex, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain
A. Sánchez-Torres
Affiliation:
Psychiatry, Navarre Hospital Complex, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain
M. Cuesta
Affiliation:
Psychiatry, Navarre Hospital Complex, IdiSNA, Navarre Institute for Health Research, Pamplona, Spain
A. González-Pinto
Affiliation:
Department Of Psychiatry, Araba University Hospital, Araba University Hospital, BIOARABA RESEARCH INSTITUTE, University OF THE BASQUE COUNTRY, CIBERSAM, Vitoria-Gasteiz, Spain
*
*Corresponding author.

Abstract

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Introduction

Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the direction of their associations is not clear.

Objectives

The aim of the study was to analyze the influence of social cognition as a mediator between cognitive reserve and cognitive domains on functioning in FEP both at baseline and at 2 years.

Methods

The sample of the study was composed of 282 FEP patients followed up for 2 years. To analyze whether social cognition mediates the influence of cognitive reserve and cognitive domains on functioning, a path analysis was performed. The statistical significance of any mediation effects was evaluated by bootstrap analysis.

Results

At baseline, as neither cognitive reserve nor the cognitive domains studied were related to functioning, the conditions for mediation were not satisfied. Nevertheless, at 2 years of follow-up, social cognition acted as a mediator between cognitive reserve and functioning. Likewise, social cognition was a mediator between verbal memory and functional outcome. The results of the bootstrap analysis confirmed these significant mediations (95% bootstrapped CI (−10.215 to −0.337) and (−4.731 to −0.605) respectively).

Conclusions

Cognitive reserve and neurocognition are related to functioning, and social cognition mediates in this relationship.

Disclosure

This work was supported by the Carlos III Institute of Health and European Fund for Regional Development (PI08/1213, PI11/ 01977, PI14/01900, PI08/01026, PI11/02831, PI14/01621, PI08/1161, PI16/ 00359, PI16/01164, PI18/00805), the Basque Foundation for He

Keywords

first episode psychosissocial cognitioncognitive reservefunctioning
Type
Abstract
Information
European Psychiatry , Volume 64 , Special Issue S1: Abstracts of the 29th European Congress of Psychiatry , April 2021 , pp. S163
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of the European Psychiatric Association
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