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Serotonin, insulin, leptin and glycolipid metabolic factor’s relationship in obesity

Published online by Cambridge University Press:  19 July 2023

S. Palermo ,
I. Chiarantini ,
G. Cappellato ,
A. Arone ,
L. Massoni ,
S. Fantasia ,
M. Violi  and
D. Marazziti
S. Palermo
Affiliation:
Aoup, Pisa, Italy
I. Chiarantini*
Affiliation:
Aoup, Pisa, Italy
G. Cappellato
Affiliation:
Aoup, Pisa, Italy
A. Arone
Affiliation:
Aoup, Pisa, Italy
L. Massoni
Affiliation:
Aoup, Pisa, Italy
S. Fantasia
Affiliation:
Aoup, Pisa, Italy
M. Violi
Affiliation:
Aoup, Pisa, Italy
D. Marazziti
Affiliation:
Aoup, Pisa, Italy
*
*Corresponding author.

Abstract

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Introduction

Obesity, defined by an excessive body fat accumulation, is a non-communicable condition attaining epidemic proportions in economically developed countries.

Objectives

To provide evidence to the link between serotonin (5-HT), energy metabolism and the human obese phenotype, the present study investigated the binding and function of the platelet 5-HT transporter (SERT), in relation to circulating insulin, leptin, glycolipid metabolic parameters and body-mass indices (BMIs, Kg m-2).

Methods

The study included an observational clinical cohort of 74 drug-free subjects (51W; 23M), recruited on the basis of divergent BMIs (16.5-54.8 Kg m-2). All subjects were tested for their blood glycolipid profile together platelet [3H]-paroxetine ([3H]-Par) binding and [3H]-5-HT reuptake measurements from April 1st to June 30th 2019.

Results

The [3H]-Par Bmax (fmol/mg proteins) was progressively reduced with increasing BMIs (p<.001), without changes in affinity. Moreover, Bmax was negatively correlated with BMI, waist/hip circumferences, triglycerides, glucose, insulin and leptin, while positively with HDL cholesterol (p<.01). The reduction of 5-HT uptake rate (Vmax, pmol//min/109platelets) amongst BMI groups was not statistically significant, but Vmax negatively correlated with leptin and uptake affinity values (p<.05). Besides, [3H]-Par affinity values positively correlated with glycaemia and triglycerides, while [3H]-5-HT reuptake affinity with glycaemia only (p<.05). Finally, these correlations were specific of obese subjects, while, from multivariate linear-regression analysis conducted on all subjects, insulin (p=.006) resulting negatively related to Bmax independently from BMI.

Conclusions

The present findings would suggest the presence of a dysfunctional insulin/5-HT/leptin axis in obesity, differentially impinging the density, function and/or affinity of the platelet SERT, as the result of complex appetite/reward-related interactions between the brain, gut, pancreatic islets and adipose tissue. In addition, they support the foremost cooperation of insulin and 5-HT in maintaining energy homeostasis.

Disclosure of Interest

None Declared

Type
Abstract
Information
European Psychiatry , Volume 66 , Special Issue S1: Abstracts of the 31st European Congress of Psychiatry , March 2023 , pp. S422 - S423
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association
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