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Serological Markers of Rheumatois Arthritis in the Acute Phase of Schizophrenia

Published online by Cambridge University Press:  15 April 2020

W. Manoubi ,
S. Samoud ,
Y. El Kissi ,
N. Hannachi ,
I. Ghedira ,
N. Bel Hadj Ali  and
J. Boukadida
W. Manoubi
Affiliation:
Cytogenetics and Biomolecular Genetics, Farhat Hached Hospital, SOUSSE, Tunisia
S. Samoud
Affiliation:
Laboratory of immunology and bacteriology, Farhat Hached Hospital, SOUSSE, Tunisia
Y. El Kissi
Affiliation:
Department of psychiatry, Farhat Hached Hospital, SOUSSE, Tunisia
N. Hannachi
Affiliation:
Laboratory of immunology and bacteriology, Farhat Hached Hospital, SOUSSE, Tunisia
I. Ghedira
Affiliation:
Laboratory of immunology and bacteriology, Farhat Hached Hospital, SOUSSE, Tunisia
N. Bel Hadj Ali
Affiliation:
Department of psychiatry, Farhat Hached Hospital, SOUSSE, Tunisia
J. Boukadida
Affiliation:
Laboratory of immunology and bacteriology, Farhat Hached Hospital, SOUSSE, Tunisia

Abstract

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The objective of this study was to determine the frequency of rheumatoid factors (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP) in patients with schizophrenia in acute phase and in healthy blood donors (HBD).

Materials and methods

Our retrospective study was performed on 80 patients with schizophrenia newly admitted in closed wards of the department of Psychiatry, Farhat Hached Hospital of Sousse, Tunisia during 2010. Eighty HBD with no history of autoimmune or mental diseases served as controls. Search for RF and anti-CCP antibodies were detected by Enzyme-linked immunosorbent assay (ELISA).

Results

RF were significantly more frequent in schizophrenic patients than in controls (17.5% vs 3.75%, p = 0.01) and RF-IgM isotype was more frequent in schizophrenic patients than in HBD 12.5%. Anti-CCP was detected only in seven patients with schizophrenia with a frequency of 8.75% and in five HBD with a frequency of 6.25%. The frequency of serological markers of RA (FR IgG or IgA or IgM or anti-CCP) was significantly higher in patients than in HBD (23.75% vs 11.25%, p = 0.037).

Conclusion

Contrary to literature data, our study found a high frequency of RF in the acute phase of schizophrenia and particularly of the IgM isotype. Thus a large population study would be interesting to confirm this association between the RA and schizophrenia.

Type
Article: 0925
Information
European Psychiatry , Volume 30 , Issue S1: Abstracts of the 23rd European Congress of Psychiatry , March 2015 , pp. 1
Copyright
Copyright © European Psychiatric Association 2015
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