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Rosa Damascena Improved Sexual Dysfunction in Males Under Methadone Treatment – Results from a Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Published online by Cambridge University Press:  23 March 2020

V. Farnia ,
F. Tatari ,
M. Alikhani ,
J. Shakeri ,
M. Taghizadeh ,
V.T. Ngo ,
D. Sadeghi Bahmani ,
E. Holsboer-Trachsler  and
S. Brand
V. Farnia
Affiliation:
Kermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah, Iran
F. Tatari
Affiliation:
Kermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah, Iran
M. Alikhani
Affiliation:
Kermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah, Iran
J. Shakeri
Affiliation:
Kermanshah University of Medical Sciences, Substance Abuse Prevention Research Center, Psychiatry Department, Kermanshah, Iran
M. Taghizadeh
Affiliation:
Kashan University of Medical Sciences, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan, Iran
V.T. Ngo
Affiliation:
Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland
D. Sadeghi Bahmani
Affiliation:
Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland
E. Holsboer-Trachsler
Affiliation:
Psychiatric Clinics of the University of Basel, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland
S. Brand
Affiliation:
Psychiatric University Hospital, Center for Affective, Stress and Sleep Disorders, Basel, Switzerland

Abstract

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Introduction

Patients with severe opioid dependency might be treated with methadone, a pure μ-opioid-receptor, with promising results. Though, as for opioids, side effects are high, and among those, sexual dysfunction is among the most disturbing side effects.

Aims

Investigating the influence of Rosa Damascena oil to improve sexual dysfunction among male methadone users.

Methods

A total of 60 male patients (mean age: 30 years) with diagnosed opioid dependence and currently under treatment of methadone were randomly assigned either to the verum (Rosa Damascenca oil drops) or placebo condition. At baseline, and four and eight weeks later, patients completed self-rating questionnaires covering sexual dysfunction and happiness.

Results

Over time sexual dysfunction decreased and happiness increased in the verum, but not in the placebo condition.

Conclusions

Results from this double blind, randomized, and placebo-controlled clinical trial showed that Rosa Damascena oil improved sexual dysfunction and happiness among male opioid addicts while under substitution treatment with methadone.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster Walk: Sexual medicine and mental health/sleep disorders and stress/eating disorders
Information
European Psychiatry , Volume 41 , Issue S1: Abstract of the 25th European Congress of Psychiatry , April 2017 , pp. S281
Copyright
Copyright © European Psychiatric Association 2017
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