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The Role of Base Excision Repair in Major Depressive Disorder and Bipolar Disorder

Published online by Cambridge University Press:  01 September 2022

M. Kucuker ,
A. Ozerdem ,
D. Ceylan ,
A. Cabello-Arreola ,
M.C. Ho ,
B. Joseph ,
L. Webb ,
P. Croarkin ,
M. Frye  and
M. Veldic
M. Kucuker
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
A. Ozerdem
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
D. Ceylan
Affiliation:
Koc University, Department Of Psychiatry & Psychology, Istanbul, Turkey
A. Cabello-Arreola
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Scottsdale, United States of America
M.C. Ho
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
B. Joseph
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
L. Webb
Affiliation:
Mayo Clinic, Alix School Of Medicine, rochester, United States of America
P. Croarkin
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
M. Frye
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
M. Veldic*
Affiliation:
Mayo Clinic Depression Center, Department Of Psychiatry & Psychology, Rochester, United States of America
*
*Corresponding author.

Abstract

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Introduction

In vivo and in vitro studies suggest that inflammation and oxidative damage may contribute to the pathogenesis of major depressive disorder (MDD) and bipolar disorder (BD). Imbalance between DNA damage and repair is an emerging research area examining pathophysiological mechanisms of these major mood disorders.

Objectives

This systematic review sought to examine current evidence on the association between mood disorders and deficits in base excision repair (BER), the primary repair mechanism for repair of oxidation-induced DNA lesions.

Methods

We conducted a comprehensive literature search of Ovid MEDLINE® Epub Ahead of Print, Ovid MEDLINE® In-Process & Other Non-Indexed Citations, Ovid MEDLINE® Daily, EMBASE (1947), and PsycINFO for studies investigating the alterations in base excision repair in patients with MDD or BD.

Results

A total of 1,364 records were identified. 1,352 records remained after duplicates were removed. 24 records were selected for full-text screening and a remaining 12 articles were included in the qualitative synthesis. SNPs (Single Nucleotide Polymorphisms) of several BER genes have been shown to be associated with MDD and BD. However, it was difficult to draw conclusions from BER gene expression studies due to conflicting findings and the small number of studies.

Conclusions

Future studies comparing DNA repair during the manic or depressive episode to remission will give us a better insight regarding the role of DNA repair in mood disorders. These alterations might be utilized as diagnostic and prognostic biomarkers as well as measuring treatment response.

Disclosure

No significant relationships.

Keywords

major depressive disorderOxidative damageDNA repairbase excision repair
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S401
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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